Pharmacology

[18F]FET PET-Guided management of pseudoprogression in glioblastoma (FET POPPING): the study protocol for a diagnostic randomized clinical trial

PMCID: PMC12175455 PMID: 40528226 DOI: 10.1186/s13063-025-08921-8 Journal: Trials Publication Date: 2025-6-17 Authors: Ruijters VJ, Snijders TJ, van der Pol JA, van de Giessen EM, Niers JM, et al. Key Points * First comprehensive randomized trial investigating FET PET's utility in differentiating pseudoprogression from true tumor progression in

Pharmacology

Cost-effectiveness analysis of two inhaled antibiotics for stable Bronchiectasis with Pseudomonas aeruginosa infections in China

PMCID: PMC12176172 PMID: 40531911 DOI: 10.1371/journal.pone.0324254 Journal: PloS one Publication Date: 2025-6-18 Authors: Chen W, Chen X, Lai L, Hong B, Zhi C, et al. Key Points * TIS provides a cost-effective alternative to CMS for Bronchiectasis patients with Pseudomonas aeruginosa infections * Cost savings of CNY 41,

Pharmacology

Plant-Based Diet and Risk of Iron-deficiency Anemia. A Review of the Current Evidence and Implications for Preventive Strategies

PMCID: PMC12174276 PMID: 40528105 DOI: 10.1007/s13668-025-00671-y Journal: Current nutrition reports Publication Date: 2025-6-18 Authors: López-Moreno M, Castillo-García A, Roldán-Ruiz A, Viña I, Bertotti G Key Points * Plant-based diets may activate adaptive physiological mechanisms to optimize non-heme iron absorption * Vegetarian and vegan diets can potentially provide adequate iron intake

Pharmacology

Perceptions of chemoprevention among individuals at high risk of oral cancer: qualitative study within the UK-based SAVER trial

PMCID: PMC12182162 PMID: 40527552 DOI: 10.1136/bmjopen-2025-101326 Journal: BMJ open Publication Date: 2025 Authors: Sherratt F, McCarthy C, Jiménez-Tomàs A, Perry J, Kuruvilla R, et al. Key Points * Individuals with oral epithelial dysplasia are generally open to chemoprevention research, motivated by potential cancer risk reduction * Most participants (11/20)

Pharmacology

Multimodal CustOmics: A unified and interpretable multi-task deep learning framework for multimodal integrative data analysis in oncology

PMCID: PMC12173418 PMID: 40526743 DOI: 10.1371/journal.pcbi.1013012 Journal: PLoS computational biology Publication Date: 2025-6-17 Authors: Benkirane H, Vakalopoulou M, Planchard D, Adam J, Olaussen K, et al. Key Points * Multimodal CustOmics achieved superior predictive performance across multiple cancer types, with classification AUC consistently above 98% when integrating

Pharmacology

Long-term anti-SARS-CoV-2 antibody trajectories after neutralizing monoclonal antibody treatment

PMCID: PMC12176123 PMID: 40531973 DOI: 10.1371/journal.pone.0325561 Journal: PloS one Publication Date: 2025-6-18 Authors: Munroe ES, Grandits GA, Hyzy RC, Prescott HC, Barrett TW, et al. Key Points * nMAb treatment did not compromise the body's natural immune response in hospitalized COVID-19 patients * Sustained anti-spike neutralization

Pharmacology

Comparative effectiveness of interventions to facilitate deprescription of benzodiazepines and other sedative hypnotics: systematic review and meta-analysis

PMCID: PMC12171951 PMID: 40527546 DOI: 10.1136/bmj-2024-081336 Journal: BMJ (Clinical research ed.) Publication Date: 2025 Authors: Zeraatkar D, Nagraj SK, Ling M, Jassal T, Kirsh S, et al. Key Points * Patient education and pharmacist-led interventions showed the most promise in facilitating BSH discontinuation * Low-certainty evidence suggests 144 more patients

Pharmacology

Differing Genetics of Saline and Cocaine Self‐Administration in the Hybrid Mouse Diversity Panel

PMCID: PMC12173464 PMID: 40527326 DOI: 10.1111/gbb.70029 Journal: Genes, brain, and behavior Publication Date: 2025-6-17 Authors: Khan AH, Bagley JR, LaPierre N, Gonzalez‐Figueroa C, Spencer TC, et al. Key Points * 145 unique genetic loci were identified for saline self-administration, indicating complex genetic regulation of behavioral endpoints * Only

Pharmacology

Treatment with gemcitabine/cisplatin and durvalumab for advanced biliary tract cancer – real-world data from a multicenter German patient population

PMCID: PMC12176970 PMID: 40533571 DOI: 10.1007/s00432-025-06239-1 Journal: Journal of cancer research and clinical oncology Publication Date: 2025-6-18 Authors: Gerhardt F, Müller C, Venerito M, Chater J, Mohr R, et al. Key Points * First real-world validation of ICI-based therapy for advanced biliary tract cancers using gemcitabine/cisplatin and durvalumab

Pharmacology

Trends of potentially inappropriate prescribing among older outpatients in China between 2015–21

PMCID: PMC12178595 PMID: 40537054 DOI: 10.7189/jogh.15.04190 Journal: Journal of global health Publication Date: 2025-6-20 Authors: Tian F, Chen Z, Zhang Y, Feng Q Key Points * Overall PIP prevalence remained stable at approximately 29%, but multiple PIM-related prescriptions increased (AAPC = 4.45) * Sedative-hypnotic medications showed significant upward

Pharmacology

Targeting circulating tumor cell‒neutrophil interactions: nanoengineered strategies for inhibiting cancer metastasis

PMCID: PMC12175327 PMID: 40528159 DOI: 10.1186/s12951-025-03522-8 Journal: Journal of nanobiotechnology Publication Date: 2025-6-17 Authors: Su Y, Leng M, Yang Q, Jiang W, Xiang G, et al. Key Points * Neutrophil-CTC interactions are a critical mechanism driving cancer metastasis through multiple biological processes * Nanotechnology-based drug delivery systems show promise in

Pharmacology

Long‐Acting Injectable Antipsychotic Use and Discontinuation Rates in Children and Adolescents With Schizophrenia Using Medicaid Claims Data

PMCID: PMC12172391 PMID: 40525645 DOI: 10.1111/eip.70063 Journal: Early intervention in psychiatry Publication Date: 2025-6-17 Authors: Ward TM, Xu J, Hall DB, Chen X, Benavides S, et al. Key Points * LAI antipsychotics represent an emerging treatment strategy for pediatric psychiatric populations, potentially improving medication adherence * Paliperidone palmitate showed