Status and associated factors of psychological resilience of Chinese medical aid team members under public health emergencies in a cross-sectional study

PMCID: PMC12173397 PMID: 40526630 DOI: 10.1371/journal.pone.0324952 Journal: PloS one Publication Date: 2025-6-17 Authors: Wei X, Liang Y, Huang J Key Points * Psychological resilience is significantly influenced by professional experience, family support, and cultural adaptation * 53.9% of CMATMs reported experiencing loneliness, which negatively impacted psychological resilience

Structured light imaging mesoscopy: detection of embedded morphological changes in superficial tissues

PMCID: PMC12175002 PMID: 40534904 DOI: 10.1117/1.JBO.30.6.065001 Journal: Journal of biomedical optics Publication Date: 2025-6-18 Authors: Parsanasab M, Mehendale AM, Karrobi K, Roblyer D, Venugopalan V Key Points * SLIM provides a novel, non-invasive method for detecting subsurface tissue microstructural changes * Optimal imaging parameters vary significantly

Experimental evolution of a pathogen confronted with innate immune memory increases variation in virulence

PMCID: PMC12176410 PMID: 40532126 DOI: 10.1371/journal.ppat.1012839 Journal: PLoS pathogens Publication Date: 2025-6-18 Authors: Korša A, Baur M, Schulz NK, Anaya-Rojas JM, Mellmann A, et al. Key Points * Immune priming creates selective pressure that increases pathogen virulence variability without compromising host defense mechanisms * 96.6% probability of

Long‐Term or Recurrent Antibiotic Use in Early Life and the Risk of Type 2 Diabetes: A Population‐Based Prospective Cohort and a Case–Control Study

PMCID: PMC12176498 PMID: 40533417 DOI: 10.1111/1753-0407.70113 Journal: Journal of diabetes Publication Date: 2025-6-18 Authors: Li Z, He Q, He X, Xing X, Fu S, et al. Key Points * Long-term or recurrent antibiotic use during childhood may significantly increase type 2 diabetes risk * 26% higher hazard ratio for

Determining the Effects of Emotional Freedom Techniques on Sexual Dysfunction and Self‐Care Management in Women Diagnosed With Multiple Sclerosis

PMCID: PMC12171629 PMID: 40525294 DOI: 10.1002/brb3.70635 Journal: Brain and behavior Publication Date: 2025-6-17 Authors: Çuvadar A, Güneş A, Baş YÇ, Kehaya S Key Points * EFT intervention demonstrated significant improvements in sexual functioning for MS patients * Mean MSISQ-19 primary subscale scores reduced from 10.56 ± 4.11 at

Exploring Post‐Retrieval Strategies to Reduce Drug Craving in Methamphetamine Use Disorders

PMCID: PMC12178206 PMID: 40536786 DOI: 10.1111/adb.70049 Journal: Addiction biology Publication Date: 2025-6-19 Authors: Li J, Dong Y, Chen W, Wang J, Zheng X Key Points * First human study demonstrating memory reconsolidation interventions can effectively reduce methamphetamine use disorder cravings * R-E and R-CT groups showed significant craving suppression

Deep Transcranial Magnetic Stimulation in Patients With Opioid Use Disorder: A Double‐Blind, Placebo‐Controlled Randomized Trial

PMCID: PMC12178270 PMID: 40536869 DOI: 10.1111/adb.70057 Journal: Addiction biology Publication Date: 2025-6-19 Authors: Guldas S, Tumkaya S, Yucens B Key Points * First double-blind, randomized controlled trial evaluating wide-volume TMS for opioid use disorder * No serious adverse events were observed, suggesting the safety of the wvTMS approach * Further

The effect of cognitive behavioural therapy on pain and disability in chronic non-specific low back pain: An overview of systematic reviews

PMCID: PMC12173195 PMID: 40526738 DOI: 10.1371/journal.pone.0325122 Journal: PloS one Publication Date: 2025-6-17 Authors: Leung T, Low MK, Yao PC, Pinho-Gomes AC Key Points * CBT provides statistically significant but modest improvements in pain intensity and disability for chronic low back pain patients * Combination interventions (CBT + active treatments)

Differential risk factors of fibrosis between lean and obese MAFLD

PMCID: PMC12177025 PMID: 40531393 DOI: 10.1007/s10238-025-01749-1 Journal: Clinical and experimental medicine Publication Date: 2025-6-18 Authors: Mostafa AM, Fouad Y, Gaber Y, Alem SA, Pan Z, et al. Key Points * Lean MAFLD patients (3.6% prevalence) have distinct metabolic characteristics, including higher hypercholesterolemia and hypertension compared to obese patients

Spatio-temporal heterogeneity of metro ridership under major epidemic conditions

PMCID: PMC12173233 PMID: 40526727 DOI: 10.1371/journal.pone.0326114 Journal: PloS one Publication Date: 2025-6-17 Authors: Shi B, Yu L, Yang Q, Zhang N, Yang N Key Points * COVID-19 caused substantial disruptions in metro ridership, with most land use types experiencing minimum impact in 2020 * Residential land use maintained

Long-term outcomes after a trimalleolar fracture involving the posterior malleolar fragment: an 11-year follow-up

PMCID: PMC12176937 PMID: 40531350 DOI: 10.1007/s00402-025-05959-w Journal: Archives of orthopaedic and trauma surgery Publication Date: 2025-6-18 Authors: Chidda A, Soares S, Tannast M, Schwab J, Seidel A Key Points * PMF fixation did not improve long-term clinical outcomes in trimalleolar ankle fractures * Fixated group had significantly larger PMF sizes

Kruppel-like factor 9 may regulate the inflammatory injury of chondrocytes by affecting NF-κB signaling

PMCID: PMC12175337 PMID: 40533763 DOI: 10.1186/s13018-025-05974-y Journal: Journal of orthopaedic surgery and research Publication Date: 2025-6-18 Authors: Gu H, Han X, Ding Y, Deng J Key Points * KLF9 is a critical molecular factor that can potentially mitigate inflammatory responses in osteoarthritis * KLF9 overexpression reduced pro-inflammatory cytokines by up

Neurology

Down syndrome with Alzheimer's disease brains have increased iron and associated lipid peroxidation consistent with ferroptosis

PMCID: PMC12177674 PMID: 40536124 DOI: 10.1002/alz.70322 Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association Publication Date: 2025-6-19 Authors: Thorwald MA, Godoy‐Lugo JA, Kerstiens E, Garcia G, Kim M, et al. Key Points * DSAD demonstrates more pronounced iron-mediated oxidative stress compared

Oncology

Using Electronic Health Records to Classify Cancer Site and Metastasis

PMCID: PMC12176508 PMID: 40533095 DOI: 10.1055/a-2544-3117 Journal: Applied clinical informatics Publication Date: 2025-6-18 Authors: Kroenke K, Ruddy KJ, Pachman DR, Grzegorczyk V, Herrin J, et al. Key Points * Multiple EHR data extraction methods can effectively identify cancer site and metastatic status * 44.4% of patients were identified as

Immunology

Kruppel-like factor 9 may regulate the inflammatory injury of chondrocytes by affecting NF-κB signaling

PMCID: PMC12175337 PMID: 40533763 DOI: 10.1186/s13018-025-05974-y Journal: Journal of orthopaedic surgery and research Publication Date: 2025-6-18 Authors: Gu H, Han X, Ding Y, Deng J Key Points * KLF9 is a critical molecular factor that can potentially mitigate inflammatory responses in osteoarthritis * KLF9 overexpression reduced pro-inflammatory cytokines by up

Infectious_Disease

Pandemic-related experiences of older adults and people with disabilities

PMCID: PMC12173368 PMID: 40526622 DOI: 10.1371/journal.pone.0325306 Journal: PloS one Publication Date: 2025-6-17 Authors: Mortenson WB, Esfandiari E, Mohammadi S, Sakakibara B, Schmidt J, et al. Key Points * COVID-19 restrictions dramatically altered capabilities and functionings for people with disabilities, creating unique challenges in daily life * 71 participants

Oncology

Targeting Drp1 inhibits ESCC progression via the ROS-PGC1-α-Nrf1/2 pathway

PMCID: PMC12175380 PMID: 40528181 DOI: 10.1186/s12967-025-06697-8 Journal: Journal of translational medicine Publication Date: 2025-6-17 Authors: Jiang Z, Yang Y, Zhou J, Li X, Meng Q, et al. Key Points * Drp1 overexpression is a significant driver of ESCC growth and metastasis * High Drp1 expression correlates with poor patient prognosis

Oncology

PDGF‐D Promotes Epithelial–Mesenchymal Transition of Glioma Cells Through the NF‐κB/NOTCH1 Pathway

PMCID: PMC12175480 PMID: 40530904 DOI: 10.1002/cam4.71002 Journal: Cancer medicine Publication Date: 2025-6-18 Authors: Li Y, Zhao Y, Shi M, Ma X, Jia M, et al. Key Points * PDGF-D expression positively correlates with glioma malignancy and WHO tumor grade * Knockdown of PDGF-D significantly reduced colony formation by p

Pulmonology

N95 masks increase brain blood velocity and parasympathetic outflow, yet worsen orthostatic symptoms in a healthy cohort

PMCID: PMC12177107 PMID: 40534183 DOI: 10.14814/phy2.70402 Journal: Physiological reports Publication Date: 2025-6-18 Authors: Pereira TJ, Edgell H Key Points * Mask wearing increased systolic cerebral blood flow but paradoxically worsened orthostatic intolerance symptoms * Total Vanderbilt Orthostatic Symptom Score increased from 12 to 20 during masked trials (p=0.

Oncology

MicroRNA Let‐7b‐5p Targets IGF1R to Inhibit the Progression of Hepatocellular Carcinoma Through the AKT/mTOR Pathway

PMCID: PMC12175197 PMID: 40530890 DOI: 10.1002/cam4.71000 Journal: Cancer medicine Publication Date: 2025-6-18 Authors: Liang J, Li A, Chen J, Cao N, Zhu T, et al. Key Points * Let-7b-5p is significantly downregulated in HCC, associated with reduced patient survival (p = 0.04805) * Overexpression of Let-7b-5p decreased HCC cell

Oncology

Modulating autophagy in KRAS mutant colorectal cancer using combination of oncolytic reovirus and carbamazepine

PMCID: PMC12173229 PMID: 40526688 DOI: 10.1371/journal.pone.0326029 Journal: PloS one Publication Date: 2025-6-17 Authors: Shaykevich A, Chae D, Silverman I, Goel S, Maitra R Key Points * Carbamazepine and oncolytic reovirus demonstrate synergistic effects in inducing autophagy in KRAS-mutated colorectal cancer cells * Dual treatment significantly increased autophagy-related protein

Oncology

Hypoxia‐induced PGK1 expression promotes esophageal squamous cell carcinoma progression via stimulating MYH9‐mediated GSK3β/β‐catenin signalling

PMCID: PMC12177104 PMID: 40534132 DOI: 10.1002/ctm2.70376 Journal: Clinical and translational medicine Publication Date: 2025-6-18 Authors: Xu J, Wu L, Chen T, Liu Y, Zhang Y, et al. Key Points * Elevated PGK1 levels correlate with poor survival and advanced tumor stages in ESCC patients * PGK1 promotes tumor progression

Surgery

A narrative review and scoring proposal for secondary lumbar instability after lumbar decompression surgery

PMCID: PMC12177027 PMID: 40531241 DOI: 10.1007/s00701-025-06590-9 Journal: Acta neurochirurgica Publication Date: 2025-6-18 Authors: Abramovic A, Lener S, Hartmann S, Thomé C Key Points * A comprehensive 14-point scoring system was developed to predict secondary lumbar instability risk after decompressive surgery * Key risk factors include disc height > 6.5

Immunology

Extensive Clinical Flow Cytometric Lymphocyte Phenotyping in Myasthenia Gravis: A Single‐Center Study

PMCID: PMC12172393 PMID: 40525756 DOI: 10.1111/jnc.70126 Journal: Journal of neurochemistry Publication Date: 2025-6-17 Authors: Lindahl H, Petersson M, Enoksson SL, Piehl F, Brauner S Key Points * Untreated MG patients show distinctive lymphocyte subset alterations, particularly elevated CD4 T cell frequencies * High CD4 T cell percentages (>75%