Pathology - CurrentMed (Page 3)

Oncology

A multi-gene predictive model for the radiation sensitivity of nasopharyngeal carcinoma based on machine learning

PMCID: PMC12176387 PMID: 40530955 DOI: 10.7554/eLife.99849 Journal: eLife Publication Date: 2025-6-18 Authors: Li K, Liang J, Li N, Fang J, Zhou X, et al. Key Points * NPC-RSS provides a robust, data-driven approach to predicting radiotherapy response in nasopharyngeal carcinoma * Model achieved high predictive accuracy with AUC of

Oncology

Genetic characteristics of blastic plasmacytoid dendritic cell neoplasm: A single institution experience

PMCID: PMC12173198 PMID: 40526100 DOI: 10.18632/oncotarget.28742 Journal: Oncotarget Publication Date: 2025 Authors: Fei F, Telatar M, Tomasian V, Chang L, Danilova O, et al. Key Points * TET2 and ASXL1 mutations were predominant, occurring in 57% and 33% of BPDCN cases, respectively * Patients with ≥3 mutations and TET2

Pathology

Epithelial zinc finger protein in lung adenocarcinoma: prognostic biomarker with molecular and clinical implications

PMCID: PMC12175355 PMID: 40533866 DOI: 10.1186/s41065-025-00476-7 Journal: Hereditas Publication Date: 2025-6-18 Authors: Wen X, Zhu J, Xi D, Chen M, Zeng D, et al. Key Points * EZF expression is significantly downregulated in lung adenocarcinoma, yet correlates with advanced tumor progression * High-risk patients with low EZF expression showed 1.

Oncology

Molecular landscape of HER2-mutated non-small cell lung cancer in Northeastern Brazil: Clinical, histopathological, and genomic insights

PMCID: PMC12173199 PMID: 40526089 DOI: 10.18632/oncotarget.28737 Journal: Oncotarget Publication Date: 2025 Authors: Nogueira CD, Frota S, Chaves HL, de Sousa JC, Veloso GD, et al. Key Points * HER2 mutations were identified in 4.9% of NSCLC cases, with exon 20 insertions being the most prevalent * The DESTINY-Lung01