Pathology - CurrentMed (Page 2)

Pathology

Epithelial zinc finger protein in lung adenocarcinoma: prognostic biomarker with molecular and clinical implications

PMCID: PMC12175355 PMID: 40533866 DOI: 10.1186/s41065-025-00476-7 Journal: Hereditas Publication Date: 2025-6-18 Authors: Wen X, Zhu J, Xi D, Chen M, Zeng D, et al. Key Points * EZF expression is significantly downregulated in lung adenocarcinoma, yet correlates with advanced tumor progression * High-risk patients with low EZF expression showed 1.

Oncology

Molecular landscape of HER2-mutated non-small cell lung cancer in Northeastern Brazil: Clinical, histopathological, and genomic insights

PMCID: PMC12173199 PMID: 40526089 DOI: 10.18632/oncotarget.28737 Journal: Oncotarget Publication Date: 2025 Authors: Nogueira CD, Frota S, Chaves HL, de Sousa JC, Veloso GD, et al. Key Points * HER2 mutations were identified in 4.9% of NSCLC cases, with exon 20 insertions being the most prevalent * The DESTINY-Lung01

Pathology

Major Complications Associated With Cerebrospinal Fluid Collection in 11 Dogs: Clinical Presentation and Imaging Characteristics

PMCID: PMC12172569 PMID: 40526210 DOI: 10.1111/jvim.70165 Journal: Journal of veterinary internal medicine Publication Date: 2025-6-17 Authors: Danciu C, McCarthy A, Crawford A Key Points * Major CSF collection complications occurred in only 0.15% of cases, but carried a high mortality rate * 7/9 dogs had MRI evidence

Neurology

Longitudinal assessment of cognitive function in testicular cancer patients prior to orchiectomy and 9 months later and associations with tumor markers

PMCID: PMC12174274 PMID: 40526183 DOI: 10.1007/s00520-025-09637-w Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer Publication Date: 2025-6-17 Authors: Højris NF, Frederiksen Y, Agerbæk M, Nielsen SH, Holt M, et al. Key Points * Low prevalence of cognitive impairment (10.3% pre-surgery,

Pathology

Inflammatory cells and remodeling in bronchial biopsies from COPD patients and controls

PMCID: PMC12173230 PMID: 40526700 DOI: 10.1371/journal.pone.0326267 Journal: PloS one Publication Date: 2025-6-17 Authors: Eagan TM, Nielsen R, Haaland I, Husebø GR, Lehmann S, et al. Key Points * COPD patients exhibit increased macrophage and eosinophil populations in bronchial submucosa * GOLD stages I/II demonstrated higher eosinophil counts

Pharmacology

Case Report WIN-MTB-2023001 WIN International Molecular Tumor Board A 62-year-old male with metastatic colorectal cancer with 5 prior lines of treatment

PMCID: PMC12175699 PMID: 40526090 DOI: 10.18632/oncotarget.28744 Journal: Oncotarget Publication Date: 2025 Authors: Hernando-Calvo A, Kurzrock R, Gonzalez NS, Magidi S, Bresson C, et al. Key Points * Comprehensive molecular profiling revealed multiple actionable genetic alterations in mCRC * Personalized treatment strategies proposed, including targeted therapies matching specific mutations * Repeated

Oncology

Bladder cancer variants share aggressive features including a CA125+ cell state and targetable TM4SF1 expression

PMCID: PMC12174346 PMID: 40527915 DOI: 10.1038/s41467-025-59888-8 Journal: Nature communications Publication Date: 2025-6-17 Authors: Yang H, Song H, Yip E, Gilpatrick T, Chang K, et al. Key Points * HV bladder cancers harbor a unique tumor cell state with distinct molecular characteristics, primarily expressing CA125, MUC4, and KRT24 * CA125+ cells

Pathology

Targeting Oncofoetal Chondroitin Sulphate Allows Identification of Tumour‐Derived Extracellular Vesicles

PMCID: PMC12173530 PMID: 40527727 DOI: 10.1002/jev2.70106 Journal: Journal of extracellular vesicles Publication Date: 2025-6-17 Authors: Enciso‐Martinez A, Løppke C, Koene JJ, Ebbelaar J, van der Geest M, et al. Key Points * First comprehensive method for specifically identifying tumor-derived extracellular vesicles using oncofoetal chondroitin sulphate * Demonstrated ofCS

Oncology

The DCDC2/ENO1 axis promotes tumor progression and immune evasion in intrahepatic cholangiocarcinoma via activating FGL1-LAG3 checkpoint

PMCID: PMC12175362 PMID: 40533767 DOI: 10.1186/s13046-025-03436-1 Journal: Journal of experimental & clinical cancer research : CR Publication Date: 2025-6-18 Authors: Wan W, Li Y, Sun W, Cheng Z, Ma F, et al. Key Points * Anti-DCDC2 autoantibodies emerge as a potential novel diagnostic biomarker for intrahepatic cholangiocarcinoma * DCDC2 promotes ICC

Pathology

Deep learning for differential diagnosis of parotid tumors based on 2.5D magnetic resonance imaging

PMCID: PMC12180351 PMID: 40531801 DOI: 10.1080/07853890.2025.2520401 Journal: Annals of medicine Publication Date: 2025-6-18 Authors: Mai W, Fan X, Zhang L, Li J, Chen L, et al. Key Points * 2.5D deep learning approach significantly improves diagnostic accuracy of parotid gland tumors * Model achieved AUC of 0.

Pathology

A three dimensional immunolabeling method with peroxidase-fused nanobodies and fluorochromized tyramide-glucose oxidase signal amplification

PMCID: PMC12177075 PMID: 40533487 DOI: 10.1038/s42003-025-08317-z Journal: Communications biology Publication Date: 2025-6-18 Authors: Yamauchi K, Koike M, Hioki H Key Points * Nanobody-based 3D-IHC technique provides superior tissue penetration compared to conventional antibodies * Achieved 9.0-fold signal amplification compared to standard fluorescence imaging * Enables multiplex molecular imaging in thick

Oncology

The Prognosis Prediction Model for Endometrial Cancer Based on DNA Methylation Signature

PMCID: PMC12174473 PMID: 40528483 DOI: 10.1002/cnr2.70218 Journal: Cancer reports (Hoboken, N.J.) Publication Date: 2025-6-17 Authors: Ran R, Wang M, Miao J Key Points * Identified 11 key genes (including POU4F3, MAL, MAGI2) that play critical roles in endometrial cancer progression through epigenetic dysregulation * Recurrence model AUC values: