Oncology - CurrentMed (Page 7)

Oncology

A multicenter prospective study to determine the optimal range of lymph node dissection in pancreatic cancer surgery after neoadjuvant chemotherapy (LYMRIN-Trial): Project study by the Japan Pancreas Society and JON 2302-P

PMCID: PMC12173190 PMID: 40526592 DOI: 10.1371/journal.pone.0325667 Journal: PloS one Publication Date: 2025-6-17 Authors: Kimura N, Shirai Y, Itoh A, Hirano K, Shibuya K, et al. Key Points * Comprehensive multicenter study addressing optimal lymph node dissection in PDAC * Evaluating metastasis rates across different pancreatic tumor locations to

Gastroenterology

Single-cell dissection of prognostic architecture and immunotherap response in Helicobacter pylori infection-associated gastric cancer

PMCID: PMC12173458 PMID: 40525824 DOI: 10.7554/eLife.99337 Journal: eLife Publication Date: 2025-6-17 Authors: Zhang X, Zhang G, Sang S, Fei Y, Cao X, et al. Key Points * H. pylori infection fundamentally reshapes gastric cancer's tumor microenvironment, increasing inflammatory and angiogenic cellular components * iCAF abundance and angiogenic

Oncology

Bladder cancer variants share aggressive features including a CA125+ cell state and targetable TM4SF1 expression

PMCID: PMC12174346 PMID: 40527915 DOI: 10.1038/s41467-025-59888-8 Journal: Nature communications Publication Date: 2025-6-17 Authors: Yang H, Song H, Yip E, Gilpatrick T, Chang K, et al. Key Points * HV bladder cancers harbor a unique tumor cell state with distinct molecular characteristics, primarily expressing CA125, MUC4, and KRT24 * CA125+ cells

Oncology

The DCDC2/ENO1 axis promotes tumor progression and immune evasion in intrahepatic cholangiocarcinoma via activating FGL1-LAG3 checkpoint

PMCID: PMC12175362 PMID: 40533767 DOI: 10.1186/s13046-025-03436-1 Journal: Journal of experimental & clinical cancer research : CR Publication Date: 2025-6-18 Authors: Wan W, Li Y, Sun W, Cheng Z, Ma F, et al. Key Points * Anti-DCDC2 autoantibodies emerge as a potential novel diagnostic biomarker for intrahepatic cholangiocarcinoma * DCDC2 promotes ICC

Oncology

Genetic characteristics of blastic plasmacytoid dendritic cell neoplasm: A single institution experience

PMCID: PMC12173198 PMID: 40526100 DOI: 10.18632/oncotarget.28742 Journal: Oncotarget Publication Date: 2025 Authors: Fei F, Telatar M, Tomasian V, Chang L, Danilova O, et al. Key Points * TET2 and ASXL1 mutations were predominant, occurring in 57% and 33% of BPDCN cases, respectively * Patients with ≥3 mutations and TET2

Oncology

A multi-gene predictive model for the radiation sensitivity of nasopharyngeal carcinoma based on machine learning

PMCID: PMC12176387 PMID: 40530955 DOI: 10.7554/eLife.99849 Journal: eLife Publication Date: 2025-6-18 Authors: Li K, Liang J, Li N, Fang J, Zhou X, et al. Key Points * NPC-RSS provides a robust, data-driven approach to predicting radiotherapy response in nasopharyngeal carcinoma * Model achieved high predictive accuracy with AUC of

Oncology

The Prognosis Prediction Model for Endometrial Cancer Based on DNA Methylation Signature

PMCID: PMC12174473 PMID: 40528483 DOI: 10.1002/cnr2.70218 Journal: Cancer reports (Hoboken, N.J.) Publication Date: 2025-6-17 Authors: Ran R, Wang M, Miao J Key Points * Identified 11 key genes (including POU4F3, MAL, MAGI2) that play critical roles in endometrial cancer progression through epigenetic dysregulation * Recurrence model AUC values:

Oncology

Molecular landscape of HER2-mutated non-small cell lung cancer in Northeastern Brazil: Clinical, histopathological, and genomic insights

PMCID: PMC12173199 PMID: 40526089 DOI: 10.18632/oncotarget.28737 Journal: Oncotarget Publication Date: 2025 Authors: Nogueira CD, Frota S, Chaves HL, de Sousa JC, Veloso GD, et al. Key Points * HER2 mutations were identified in 4.9% of NSCLC cases, with exon 20 insertions being the most prevalent * The DESTINY-Lung01