Oncology - CurrentMed (Page 2)

Gastroenterology

The Effect of Postoperative Antithrombin Supplementation on the Inflammatory and Coagulation Status of a Surgically Treated Patient With a Malignant Tumor in the Small Pelvis—Case Series

PMCID: PMC12177226 PMID: 40534446 DOI: 10.1002/cnr2.70260 Journal: Cancer reports (Hoboken, N.J.) Publication Date: 2025-6-19 Authors: Lazović R, Šarenac O Key Points * Antithrombin supplementation can effectively normalize coagulation and inflammatory responses in complex surgical patients * Observed 50-70% reduction in inflammatory markers (IL-6, CRP) within 4 postoperative days

Oncology

N6-methyladenosine-modified GPX2 impacts cancer cell stemness and TKI resistance through regulating of redox metabolism

PMCID: PMC12177039 PMID: 40533443 DOI: 10.1038/s41419-025-07764-0 Journal: Cell death & disease Publication Date: 2025-6-18 Authors: Yang X, Yu L, Shao M, Yang H, Qi K, et al. Key Points * GPX2 serves as a critical mediator of EGFR-TKI resistance in NSCLC by modulating cellular redox balance * Knockdown of GPX2

Immunology

Efficacy of NAMPT inhibition in T-cell acute lymphoblastic leukemia

PMCID: PMC12173385 PMID: 40526635 DOI: 10.1371/journal.pone.0324443 Journal: PloS one Publication Date: 2025-6-17 Authors: Vrana C, Zhang M, Rochette M, Alozie M, Oviedo H, et al. Key Points * NAMPT inhibition represents a promising targeted therapeutic approach for T-ALL * FK866 increased median survival by 39.5 days in

Gastroenterology

Impeding Quorum Sensing Among the Intestinal Microbiota Impacts the Metastatic Rate of Colorectal Cancer

PMCID: PMC12177794 PMID: 40536191 DOI: 10.1002/cam4.71009 Journal: Cancer medicine Publication Date: 2025-6-19 Authors: Dietz M, Gates TJ, Sikdar R, Subramanian S, Elias MH, et al. Key Points * QQ lactonase treatment demonstrated sex-specific effects on CRC metastasis * Male mice treated with SsoPox showed 0% metastasis compared to 30%

Oncology

Thermal ablation for pulmonary oligometastases from hepatocellular carcinoma: initial experience and retrospective study

PMCID: PMC12177983 PMID: 40533817 DOI: 10.1186/s40644-025-00896-8 Journal: Cancer imaging : the official publication of the International Cancer Imaging Society Publication Date: 2025-6-18 Authors: Hou R, Zhou X, Li Y, Qin Y, Song M, et al. Key Points * Thermal ablation achieved 100% technical success with 96.8% technical efficacy in

Immunology

CAR‐NK, a Splendid Strategy for Cancer, Especially for Gynecologic Tumor

PMCID: PMC12171998 PMID: 40525700 DOI: 10.1002/iid3.70210 Journal: Immunity, inflammation and disease Publication Date: 2025-6-17 Authors: Cao Y, Wang L, Wang L Key Points * CAR-NK cells provide a safer, more adaptable immunotherapy alternative to CAR-T cells * Potential for "off-the-shelf" manufacturing reduces personalization complexity and treatment time

Oncology

Impact of multikinase inhibitors in reshaping the treatment of advanced gastroenteropancreatic neuroendocrine tumors

PMCID: PMC12177888 PMID: 40392078 DOI: 10.1530/ERC-25-0052 Journal: Endocrine-related cancer Publication Date: 2025-6-18 Authors: Siebenhüner AR, Refardt J, Nicolas GP, Kaderli R, Walter MA, et al. Key Points * MKIs represent a significant advancement in GEP-NET treatment, offering improved progression-free survival across multiple tumor subtypes * Median PFS improvements range from

Gastroenterology

Establishing high risk factors for recurrence in stage I/II colorectal cancer: a metropolitan perspective

PMCID: PMC12175440 PMID: 40533762 DOI: 10.1186/s12957-025-03823-0 Journal: World journal of surgical oncology Publication Date: 2025-6-18 Authors: Wood PC, Zammit AP, Ferris B, Simpson FH, Burge M, et al. Key Points * Overall recurrence rate of 13.3% in early-stage CRC, with stage II patients at higher risk * Venous invasion,

Oncology

Myeloid‐Derived LGALS9‐P4HB Immune Interaction Promotes Metastasis in Gastric Cancer Through Enhanced Cell Proliferation and Lipid Metabolism

PMCID: PMC12176694 PMID: 40534096 DOI: 10.1111/jcmm.70661 Journal: Journal of cellular and molecular medicine Publication Date: 2025-6-18 Authors: Zhu X, Zhang Y, Yu A, Xiao X Key Points * Myeloid cell-derived LGALS9 and epithelial cell P4HB interaction is a previously uncharacterized mechanism driving gastric cancer metastasis * Pharmacological P4HB inhibitors

Oncology

The efficacy and therapy management of nab-paclitaxel in the real-world setting for patients with advanced breast cancer – the SERAPHINA study

PMCID: PMC12178961 PMID: 40536732 DOI: 10.1007/s00432-025-06246-2 Journal: Journal of cancer research and clinical oncology Publication Date: 2025-6-19 Authors: Schneeweiss A, Fasching PA, Thill M, van Mackelenbergh M, Marme F, et al. Key Points * Nab-paclitaxel demonstrated consistent efficacy across multiple treatment lines in advanced breast cancer * Median progression-free survival

Oncology

Outcomes Following Transoral Laser Microsurgery for T1b and T2a Glottic Squamous Cell Carcinoma With and Without Anterior Commissure Involvement: A Retrospective Chart Review

PMCID: PMC12177246 PMID: 40530452 DOI: 10.1177/19160216251348424 Journal: Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale Publication Date: 2025-6-18 Authors: Patel D, Taylor V, MacKay C, den Besten C, Rigby MH, et al. Key Points * TLM demonstrates comparable oncological outcomes

Oncology

Repurposing MDM2 inhibitor RG7388 for TP53-mutant NSCLC: a p53-independent pyroptotic mechanism via ROS/p-p38/NOXA/caspase-3/GSDME axis

PMCID: PMC12170848 PMID: 40523886 DOI: 10.1038/s41419-025-07770-2 Journal: Cell death & disease Publication Date: 2025-6-17 Authors: Tang G, Cao X, Chen J, Hui F, Xu N, et al. Key Points * RG7388 exhibits potent anti-tumor effects in TP53-mutant NSCLC through a p53-independent mechanism * Significant dose-dependent reduction in cell viability across