Neurology

Down syndrome with Alzheimer's disease brains have increased iron and associated lipid peroxidation consistent with ferroptosis

PMCID: PMC12177674 PMID: 40536124 DOI: 10.1002/alz.70322 Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association Publication Date: 2025-6-19 Authors: Thorwald MA, Godoy‐Lugo JA, Kerstiens E, Garcia G, Kim M, et al. Key Points * DSAD demonstrates more pronounced iron-mediated oxidative stress compared

Immunology

Extensive Clinical Flow Cytometric Lymphocyte Phenotyping in Myasthenia Gravis: A Single‐Center Study

PMCID: PMC12172393 PMID: 40525756 DOI: 10.1111/jnc.70126 Journal: Journal of neurochemistry Publication Date: 2025-6-17 Authors: Lindahl H, Petersson M, Enoksson SL, Piehl F, Brauner S Key Points * Untreated MG patients show distinctive lymphocyte subset alterations, particularly elevated CD4 T cell frequencies * High CD4 T cell percentages (>75%

Neurology

Mechanistic Pathways Underlying Genetic Predisposition to Atrial Fibrillation Are Associated With Different Cardiac Phenotypes and Cardioembolic Stroke Risk

PMCID: PMC12173164 PMID: 40526779 DOI: 10.1161/CIRCGEN.124.004932 Journal: Circulation. Genomic and precision medicine Publication Date: 2025-6-17 Authors: Gajendragadkar PR, Von Ende A, Murgia F, Offer A, Camm CF, et al. Key Points * Distinct genetic pathways for AF have differential effects on cardiac phenotypes and stroke risk * Muscle

Neurology

p‐Cresol and p‐Cresyl Sulphate Boost Oxidative Stress: A Systematic Review of Recent Evidence

PMCID: PMC12177445 PMID: 40534235 DOI: 10.1111/bcpt.70065 Journal: Basic & clinical pharmacology & toxicology Publication Date: 2025-6-18 Authors: Renaldi R, Wiguna T, Persico AM, Tanra AJ Key Points * p-Cresol and PCS induce oxidative stress through NADPH oxidase activation, with potential implications for neurological and metabolic disorders * Concentrations as

Neurology

Influences of Gait Training with Knee–Ankle–Foot Orthosis on Gait Ability and Independence in Severe Hemiplegia and Pusher Behavior with Unilateral Spatial Neglect Following Stroke: A Retrospective Historical Controlled Study

PMCID: PMC12177197 PMID: 40534213 DOI: 10.1002/brb3.70535 Journal: Brain and behavior Publication Date: 2025-6-18 Authors: Sawa K, Tamura M, Arai S Key Points * Long-term KAFO intervention showed differential improvements across stroke patient subgroups * Days since stroke onset and sensorimotor variability were critical predictors of gait independence (p <

Neurology

The neurobiological foundation of effective repetitive transcranial magnetic brain stimulation in Alzheimer's disease

PMCID: PMC12175030 PMID: 40530618 DOI: 10.1002/alz.70337 Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association Publication Date: 2025-6-18 Authors: Antonioni A, Martorana A, Santarnecchi E, Hampel H, Koch G Key Points * rTMS demonstrates comprehensive neurobiological modulation in AD, targeting synaptic, molecular, and

Neurology

Association Between Argatroban and Outcomes of Branch Atheromatous Disease: A Propensity‐Matched Analysis From MRI‐Based Study

PMCID: PMC12174617 PMID: 40530546 DOI: 10.1111/cns.70467 Journal: CNS neuroscience & therapeutics Publication Date: 2025-6-17 Authors: Li S, Hu H, Zhou Y, Zhang P, Chen G, et al. Key Points * Argatroban did not significantly improve functional outcomes in patients with BAD-related stroke * Excellent outcome rates were similar between

Neurology

Efficacy of transcranial direct current stimulation on seizure control in patients with refractory epilepsy: a systematic review and meta-analysis of randomized controlled trials

PMCID: PMC12177013 PMID: 40533536 DOI: 10.1007/s10143-025-03657-0 Journal: Neurosurgical review Publication Date: 2025-6-19 Authors: Hendi NI, AbuSammour Y, Khaled M, Mohamed AS, Amin AM, et al. Key Points * tDCS demonstrated a statistically significant reduction in seizure frequency across multiple follow-up periods * Seizure frequency reduction reached up to 71% in

Neurology

Longitudinal assessment of cognitive function in testicular cancer patients prior to orchiectomy and 9 months later and associations with tumor markers

PMCID: PMC12174274 PMID: 40526183 DOI: 10.1007/s00520-025-09637-w Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer Publication Date: 2025-6-17 Authors: Højris NF, Frederiksen Y, Agerbæk M, Nielsen SH, Holt M, et al. Key Points * Low prevalence of cognitive impairment (10.3% pre-surgery,

Neurology

Risk of ischemic stroke associated with anti-rheumatic agents in patients with rheumatoid arthritis: A nationwide population-based case-control study

PMCID: PMC12173416 PMID: 40526615 DOI: 10.1371/journal.pone.0326311 Journal: PloS one Publication Date: 2025-6-17 Authors: Ahn SM, Kim S, Kim YJ, Hong S, Lee CK, et al. Key Points * Sulfasalazine and hydroxychloroquine were associated with reduced stroke risk in RA patients * Glucocorticoids showed a 71% increased stroke risk

Neurology

Brain fluid physiology in ischaemic stroke; more than just oedema

PMCID: PMC12175363 PMID: 40533800 DOI: 10.1186/s12987-025-00671-8 Journal: Fluids and barriers of the CNS Publication Date: 2025-6-18 Authors: Coupland KG, Amell MF, Spratt NJ Key Points * Ischaemic stroke acutely alters CSF and ISF movement, contributing to secondary brain injury * Disrupted fluid dynamics may compromise waste clearance and increase intracranial

Neurology

The Role of Iron Homeostasis Imbalance in T2DM‐Associated Cognitive Dysfunction: A Prospective Cohort Study Utilizing Quantitative Susceptibility Mapping

PMCID: PMC12175199 PMID: 40530831 DOI: 10.1002/hbm.70263 Journal: Human brain mapping Publication Date: 2025-6-18 Authors: Cheng Z, Yang L, Li M, Zhang Q, Li J, et al. Key Points * T2DM patients showed significantly higher iron deposition in caudate and putamen nuclei compared to healthy controls * Higher magnetic susceptibility