Immunology - CurrentMed (Page 2)

Immunology

Narrowing Down Key Players in Autoimmunity via Single‐Cell Multiomics

PMCID: PMC12177686 PMID: 40534591 DOI: 10.1002/eji.202451233 Journal: European journal of immunology Publication Date: 2025-6-19 Authors: Gjurgjaj A, Conde CD Key Points * Single-cell multiomics provides unprecedented insights into the molecular mechanisms underlying autoimmune diseases * Emerging computational integration and deep-learning tools show promise for disease stratification and drug prioritization

Immunology

Clinical factors associated with growth and neoantigen reactivity of tumor infiltrating lymphocytes from metastatic epithelial cancers

PMCID: PMC12179044 PMID: 40536705 DOI: 10.1007/s00262-025-04091-3 Journal: Cancer immunology, immunotherapy : CII Publication Date: 2025-6-19 Authors: Gustafson AM, Dinerman AJ, Hitscherich KJ, Parkhurst MR, Halas H, et al. Key Points * Lung metastases demonstrated superior TIL growth (95%) compared to other resection sites * 51% of TIL harvests showed high neoantigen

Immunology

Lymphocyte immunophenotype in dogs with immune-mediated hematologic disease

PMCID: PMC12173396 PMID: 40526723 DOI: 10.1371/journal.pone.0326341 Journal: PloS one Publication Date: 2025-6-17 Authors: Blois SL, Cuq BY, Bienzle D Key Points * Dogs with IMHD demonstrated significantly lower proportions of CD4+ and CD8+ lymphocytes compared to healthy controls (p < 0.0001) * T regulatory cells were reduced

Immunology

TIGIT blockade improves anti-Mycobacterium tuberculosis immunity

PMCID: PMC12173411 PMID: 40526725 DOI: 10.1371/journal.ppat.1013228 Journal: PLoS pathogens Publication Date: 2025-6-17 Authors: Zhou J, Yang Q, Xu H, Chen H, Jiang N, et al. Key Points * TIGIT expression on CD8+ T cells is significantly elevated in active TB patients and correlates with disease severity * TIGIT

Immunology

Immune checkpoint inhibitors in cancer therapy: what lies beyond monoclonal antibodies?

PMCID: PMC12178997 PMID: 40536609 DOI: 10.1007/s12032-025-02822-1 Journal: Medical oncology (Northwood, London, England) Publication Date: 2025-6-19 Authors: Zamani MR, Šácha P Key Points * Non-antibody immune checkpoint inhibitors represent a promising frontier in cancer immunotherapy, offering more targeted and potentially less toxic treatment approaches * Multiple novel ICI candidates are currently

Immunology

Experimental evolution of a pathogen confronted with innate immune memory increases variation in virulence

PMCID: PMC12176410 PMID: 40532126 DOI: 10.1371/journal.ppat.1012839 Journal: PLoS pathogens Publication Date: 2025-6-18 Authors: Korša A, Baur M, Schulz NK, Anaya-Rojas JM, Mellmann A, et al. Key Points * Immune priming creates selective pressure that increases pathogen virulence variability without compromising host defense mechanisms * 96.6% probability of

Immunology

Kruppel-like factor 9 may regulate the inflammatory injury of chondrocytes by affecting NF-κB signaling

PMCID: PMC12175337 PMID: 40533763 DOI: 10.1186/s13018-025-05974-y Journal: Journal of orthopaedic surgery and research Publication Date: 2025-6-18 Authors: Gu H, Han X, Ding Y, Deng J Key Points * KLF9 is a critical molecular factor that can potentially mitigate inflammatory responses in osteoarthritis * KLF9 overexpression reduced pro-inflammatory cytokines by up

Immunology

Extensive Clinical Flow Cytometric Lymphocyte Phenotyping in Myasthenia Gravis: A Single‐Center Study

PMCID: PMC12172393 PMID: 40525756 DOI: 10.1111/jnc.70126 Journal: Journal of neurochemistry Publication Date: 2025-6-17 Authors: Lindahl H, Petersson M, Enoksson SL, Piehl F, Brauner S Key Points * Untreated MG patients show distinctive lymphocyte subset alterations, particularly elevated CD4 T cell frequencies * High CD4 T cell percentages (>75%

Immunology

Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis, and inflammation

PMCID: PMC12177736 PMID: 40533345 DOI: 10.26508/lsa.202503264 Journal: Life science alliance Publication Date: 2025-6-18 Authors: Huang S, Patkar OL, Schulze S, Carter-Cusack D, Millard S, et al. Key Points * IL34 deficiency leads to selective microglial depletion in grey matter brain regions * Heterozygous Il34+/- rats demonstrate partial loss

Immunology

ORM1 Mediates Ln-IgG-Induced Podocyte Damage and Autophagy via the AMPK/mTOR Signaling

PMCID: PMC12184165 PMID: 40526157 DOI: 10.1080/15476278.2025.2519614 Journal: Organogenesis Publication Date: 2025-6-17 Authors: Chen J, Zou L, Liu L, Wu C, Hu M Key Points * ORM1 plays a critical role in podocyte damage and autophagy in lupus nephritis * ORM1 knockdown increased podocyte viability by approximately 40% and

Endocrinology

Placental inflammation is increased in gestational diabetes mellitus: The role of inflammasome NLRP-3 and chemokine scavenger decoy receptor D6

PMCID: PMC12173348 PMID: 40526637 DOI: 10.1371/journal.pone.0326087 Journal: PloS one Publication Date: 2025-6-17 Authors: Onori M, Beneduce G, Colella F, Lucchetti D, Policola C, et al. Key Points * GDM is characterized by elevated pro-inflammatory cytokines and increased NLRP-3 inflammasome expression * Statistically significant differences observed: CCL-2 (p <

Immunology

Measuring cytokines in Eurasian tundra reindeer (Rangifer tarandus tarandus) with a bovine bead-based multiplex immunoassay and real-time PCR

PMCID: PMC12175305 PMID: 40533814 DOI: 10.1186/s13028-025-00819-4 Journal: Acta veterinaria Scandinavica Publication Date: 2025-6-18 Authors: Frøvoll TL, Lybeck K, Lund H, Makvandi-Nejad S, Grimholt U, et al. Key Points * First comprehensive evaluation of cytokine detection methods specifically for reindeer immunology * Successfully measured inflammatory cytokines using a cross-species multiplex assay,