Immunology

Experimental evolution of a pathogen confronted with innate immune memory increases variation in virulence

PMCID: PMC12176410 PMID: 40532126 DOI: 10.1371/journal.ppat.1012839 Journal: PLoS pathogens Publication Date: 2025-6-18 Authors: Korša A, Baur M, Schulz NK, Anaya-Rojas JM, Mellmann A, et al. Key Points * Immune priming creates selective pressure that increases pathogen virulence variability without compromising host defense mechanisms * 96.6% probability of

Immunology

Kruppel-like factor 9 may regulate the inflammatory injury of chondrocytes by affecting NF-κB signaling

PMCID: PMC12175337 PMID: 40533763 DOI: 10.1186/s13018-025-05974-y Journal: Journal of orthopaedic surgery and research Publication Date: 2025-6-18 Authors: Gu H, Han X, Ding Y, Deng J Key Points * KLF9 is a critical molecular factor that can potentially mitigate inflammatory responses in osteoarthritis * KLF9 overexpression reduced pro-inflammatory cytokines by up

Immunology

Extensive Clinical Flow Cytometric Lymphocyte Phenotyping in Myasthenia Gravis: A Single‐Center Study

PMCID: PMC12172393 PMID: 40525756 DOI: 10.1111/jnc.70126 Journal: Journal of neurochemistry Publication Date: 2025-6-17 Authors: Lindahl H, Petersson M, Enoksson SL, Piehl F, Brauner S Key Points * Untreated MG patients show distinctive lymphocyte subset alterations, particularly elevated CD4 T cell frequencies * High CD4 T cell percentages (>75%

Immunology

Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis, and inflammation

PMCID: PMC12177736 PMID: 40533345 DOI: 10.26508/lsa.202503264 Journal: Life science alliance Publication Date: 2025-6-18 Authors: Huang S, Patkar OL, Schulze S, Carter-Cusack D, Millard S, et al. Key Points * IL34 deficiency leads to selective microglial depletion in grey matter brain regions * Heterozygous Il34+/- rats demonstrate partial loss

Immunology

ORM1 Mediates Ln-IgG-Induced Podocyte Damage and Autophagy via the AMPK/mTOR Signaling

PMCID: PMC12184165 PMID: 40526157 DOI: 10.1080/15476278.2025.2519614 Journal: Organogenesis Publication Date: 2025-6-17 Authors: Chen J, Zou L, Liu L, Wu C, Hu M Key Points * ORM1 plays a critical role in podocyte damage and autophagy in lupus nephritis * ORM1 knockdown increased podocyte viability by approximately 40% and

Endocrinology

Placental inflammation is increased in gestational diabetes mellitus: The role of inflammasome NLRP-3 and chemokine scavenger decoy receptor D6

PMCID: PMC12173348 PMID: 40526637 DOI: 10.1371/journal.pone.0326087 Journal: PloS one Publication Date: 2025-6-17 Authors: Onori M, Beneduce G, Colella F, Lucchetti D, Policola C, et al. Key Points * GDM is characterized by elevated pro-inflammatory cytokines and increased NLRP-3 inflammasome expression * Statistically significant differences observed: CCL-2 (p <

Immunology

Measuring cytokines in Eurasian tundra reindeer (Rangifer tarandus tarandus) with a bovine bead-based multiplex immunoassay and real-time PCR

PMCID: PMC12175305 PMID: 40533814 DOI: 10.1186/s13028-025-00819-4 Journal: Acta veterinaria Scandinavica Publication Date: 2025-6-18 Authors: Frøvoll TL, Lybeck K, Lund H, Makvandi-Nejad S, Grimholt U, et al. Key Points * First comprehensive evaluation of cytokine detection methods specifically for reindeer immunology * Successfully measured inflammatory cytokines using a cross-species multiplex assay,

Immunology

Research Progress on Inflammation and Immune Dysregulation in PTSD

PMCID: PMC12171638 PMID: 40525295 DOI: 10.1002/brb3.70633 Journal: Brain and behavior Publication Date: 2025-6-17 Authors: Yang L, Lu J, Zhao Z, Zhang Z, Yang W, et al. Key Points * PTSD is characterized by significant immune system dysregulation with consistent pro-inflammatory cytokine elevations * Multiple studies demonstrated increased inflammatory markers

Immunology

Efficacy of NAMPT inhibition in T-cell acute lymphoblastic leukemia

PMCID: PMC12173385 PMID: 40526635 DOI: 10.1371/journal.pone.0324443 Journal: PloS one Publication Date: 2025-6-17 Authors: Vrana C, Zhang M, Rochette M, Alozie M, Oviedo H, et al. Key Points * NAMPT inhibition represents a promising targeted therapeutic approach for T-ALL * FK866 increased median survival by 39.5 days in

Immunology

CAR‐NK, a Splendid Strategy for Cancer, Especially for Gynecologic Tumor

PMCID: PMC12171998 PMID: 40525700 DOI: 10.1002/iid3.70210 Journal: Immunity, inflammation and disease Publication Date: 2025-6-17 Authors: Cao Y, Wang L, Wang L Key Points * CAR-NK cells provide a safer, more adaptable immunotherapy alternative to CAR-T cells * Potential for "off-the-shelf" manufacturing reduces personalization complexity and treatment time

Immunology

Monoclonal humanized monovalent antibody blocking therapy for anti-NMDA receptor encephalitis

PMCID: PMC12174348 PMID: 40527893 DOI: 10.1038/s41467-025-60628-1 Journal: Nature communications Publication Date: 2025-6-17 Authors: Kanno A, Kito T, Maeda M, Yamaki S, Amano Y, et al. Key Points * First monovalent antibody designed to specifically block pathogenic NMDAR autoantibodies without receptor dysfunction * Demonstrated 74% reversal of NMDAR internalization at 2.

Immunology

Gut Microbiota Reshapes the Tumor Microenvironment and Affects the Efficacy of Colorectal Cancer Immunotherapy

PMCID: PMC12175482 PMID: 40530896 DOI: 10.1002/cam4.70994 Journal: Cancer medicine Publication Date: 2025-6-18 Authors: Wang F, Chen W, Jia Y, He T, Wu S, et al. Key Points * Intestinal microbiota significantly modulates immunotherapy response in colorectal cancer * Specific bacterial strains can enhance CD8+ T cell infiltration and cytotoxicity