Gastroenterology

Differential risk factors of fibrosis between lean and obese MAFLD

PMCID: PMC12177025 PMID: 40531393 DOI: 10.1007/s10238-025-01749-1 Journal: Clinical and experimental medicine Publication Date: 2025-6-18 Authors: Mostafa AM, Fouad Y, Gaber Y, Alem SA, Pan Z, et al. Key Points * Lean MAFLD patients (3.6% prevalence) have distinct metabolic characteristics, including higher hypercholesterolemia and hypertension compared to obese patients

Gastroenterology

Neurological Manifestations of HEV Infection: A Rare Phenomenon or an Underrecognized Reality?

PMCID: PMC12177195 PMID: 40534221 DOI: 10.1002/brb3.70585 Journal: Brain and behavior Publication Date: 2025-6-18 Authors: Iza M, Ramos D, Llauradó A, Restrepo‐Vera JL, Pallero M, et al. Key Points * HEV can cause diverse neurological manifestations, including neuralgic amyotrophy and meningoradiculitis, in immunocompetent patients * Initial HEV viral loads

Gastroenterology

The Effect of Postoperative Antithrombin Supplementation on the Inflammatory and Coagulation Status of a Surgically Treated Patient With a Malignant Tumor in the Small Pelvis—Case Series

PMCID: PMC12177226 PMID: 40534446 DOI: 10.1002/cnr2.70260 Journal: Cancer reports (Hoboken, N.J.) Publication Date: 2025-6-19 Authors: Lazović R, Šarenac O Key Points * Antithrombin supplementation can effectively normalize coagulation and inflammatory responses in complex surgical patients * Observed 50-70% reduction in inflammatory markers (IL-6, CRP) within 4 postoperative days

Gastroenterology

An optimized peritonitis-induced ACLF model that reproduces the full spectrum of extrahepatic organ failures in mice

PMCID: PMC12180834 PMID: 40536682 DOI: 10.1097/HC9.0000000000000744 Journal: Hepatology communications Publication Date: 2025-7 Authors: Flores-Costa R, Duran-Güell M, Romero-Grimaldo B, Contreras BJ, Salvatella A, et al. Key Points * First comprehensive murine model reproducing full spectrum of ACLF-associated extrahepatic organ failures * Demonstrated significant increases in inflammatory markers (Il-6, Tnf)

Gastroenterology

Impeding Quorum Sensing Among the Intestinal Microbiota Impacts the Metastatic Rate of Colorectal Cancer

PMCID: PMC12177794 PMID: 40536191 DOI: 10.1002/cam4.71009 Journal: Cancer medicine Publication Date: 2025-6-19 Authors: Dietz M, Gates TJ, Sikdar R, Subramanian S, Elias MH, et al. Key Points * QQ lactonase treatment demonstrated sex-specific effects on CRC metastasis * Male mice treated with SsoPox showed 0% metastasis compared to 30%

Gastroenterology

Establishing high risk factors for recurrence in stage I/II colorectal cancer: a metropolitan perspective

PMCID: PMC12175440 PMID: 40533762 DOI: 10.1186/s12957-025-03823-0 Journal: World journal of surgical oncology Publication Date: 2025-6-18 Authors: Wood PC, Zammit AP, Ferris B, Simpson FH, Burge M, et al. Key Points * Overall recurrence rate of 13.3% in early-stage CRC, with stage II patients at higher risk * Venous invasion,

Gastroenterology

Importance of the diameter of the mechanical suture in rectal surgery in relation to benign anastomotic stenosis. Cross-sectional observational study

PMCID: PMC12176904 PMID: 40533680 DOI: 10.1007/s10151-025-03157-9 Journal: Techniques in coloproctology Publication Date: 2025-6-18 Authors: Llorach-Perucho N, Cayetano-Paniagua L, Serra-Aracil X Key Points * Postoperative rectal anastomotic stenosis rates range from 2-30%, with surgeons recognizing current rates as clinically significant * 86.1% survey response rate, with 94.3% of surgeons

Immunology

Gut Microbiota Reshapes the Tumor Microenvironment and Affects the Efficacy of Colorectal Cancer Immunotherapy

PMCID: PMC12175482 PMID: 40530896 DOI: 10.1002/cam4.70994 Journal: Cancer medicine Publication Date: 2025-6-18 Authors: Wang F, Chen W, Jia Y, He T, Wu S, et al. Key Points * Intestinal microbiota significantly modulates immunotherapy response in colorectal cancer * Specific bacterial strains can enhance CD8+ T cell infiltration and cytotoxicity

Gastroenterology

Clinical outcomes of conventional versus extended mesenteric resection in limited ileo-colonic Crohn’s disease: a systematic review and meta-analysis

PMCID: PMC12174243 PMID: 40528089 DOI: 10.1007/s00384-025-04937-3 Journal: International journal of colorectal disease Publication Date: 2025-6-18 Authors: Mostafa OE, Zaman S, Malik M, Kumar P, Kumar L, et al. Key Points * No significant clinical advantage was observed with extended mesenteric resection compared to conventional resection in Crohn's

Gastroenterology

Single-cell dissection of prognostic architecture and immunotherap response in Helicobacter pylori infection-associated gastric cancer

PMCID: PMC12173458 PMID: 40525824 DOI: 10.7554/eLife.99337 Journal: eLife Publication Date: 2025-6-17 Authors: Zhang X, Zhang G, Sang S, Fei Y, Cao X, et al. Key Points * H. pylori infection fundamentally reshapes gastric cancer's tumor microenvironment, increasing inflammatory and angiogenic cellular components * iCAF abundance and angiogenic

Gastroenterology

Laparoscopic appendectomy as the gold standard: What role remains for open surgery, conversion, and disease severity?: An analysis of 32,000 cases with appendicitis in Germany

PMCID: PMC12178000 PMID: 40533760 DOI: 10.1186/s13017-025-00626-2 Journal: World journal of emergency surgery : WJES Publication Date: 2025-6-18 Authors: Schildberg C, Weber U, König V, Linnartz M, Heisler S, et al. Key Points * Laparoscopic appendectomy became the predominant surgical approach, reaching >95% of procedures annually since 2017 * Conversion to

Gastroenterology

Differential risk factors of fibrosis between lean and obese MAFLD

PMCID: PMC12177025 PMID: 40531393 DOI: 10.1007/s10238-025-01749-1 Journal: Clinical and experimental medicine Publication Date: 2025-6-18 Authors: Mostafa AM, Fouad Y, Gaber Y, Alem SA, Pan Z, et al. Key Points * Lean MAFLD patients (3.6% prevalence) have distinct metabolic characteristics, including higher hypercholesterolemia and hypertension compared to obese patients