Endocrinology

Long‐Term or Recurrent Antibiotic Use in Early Life and the Risk of Type 2 Diabetes: A Population‐Based Prospective Cohort and a Case–Control Study

PMCID: PMC12176498 PMID: 40533417 DOI: 10.1111/1753-0407.70113 Journal: Journal of diabetes Publication Date: 2025-6-18 Authors: Li Z, He Q, He X, Xing X, Fu S, et al. Key Points * Long-term or recurrent antibiotic use during childhood may significantly increase type 2 diabetes risk * 26% higher hazard ratio for

Endocrinology

Stable heritability of type 1 diabetes in a Swedish Nationwide Cohort Study

PMCID: PMC12174315 PMID: 40527903 DOI: 10.1038/s41467-025-60813-2 Journal: Nature communications Publication Date: 2025-6-17 Authors: Wei Y, Andersson T, Liu S, Feychting M, Kuja-Halkola R, et al. Key Points * T1D incidence nearly doubled between 1982-2000, with a hazard ratio of 1.85 (95% CI: 1.65, 2.08) for children

Endocrinology

Placental inflammation is increased in gestational diabetes mellitus: The role of inflammasome NLRP-3 and chemokine scavenger decoy receptor D6

PMCID: PMC12173348 PMID: 40526637 DOI: 10.1371/journal.pone.0326087 Journal: PloS one Publication Date: 2025-6-17 Authors: Onori M, Beneduce G, Colella F, Lucchetti D, Policola C, et al. Key Points * GDM is characterized by elevated pro-inflammatory cytokines and increased NLRP-3 inflammasome expression * Statistically significant differences observed: CCL-2 (p <

Endocrinology

Cardiac structure and function across the continuum of glucose metabolism

PMCID: PMC12172345 PMID: 40526029 DOI: 10.14814/phy2.70429 Journal: Physiological reports Publication Date: 2025-6-17 Authors: Grönlund T, Kaikkonen K, Junttila MJ, Ukkola O, Kerkelä R, et al. Key Points * Higher HbA1c levels within normal and prediabetic ranges are associated with decreased myocardial contractility * Proportion of subjects with abnormal global

Endocrinology

The mediating role of inflammation-related indicators in the association of remnant cholesterol with gestational diabetes mellitus

PMCID: PMC12178596 PMID: 40537057 DOI: 10.7189/jogh.15.04172 Journal: Journal of global health Publication Date: 2025-6-20 Authors: Lin L, Lin J, Yan J, Wang X Key Points * Higher RC levels in early pregnancy are independently associated with increased GDM risk * Per unit increase in RC level corresponds to

Endocrinology

Joint association of the newly proposed dietary index for gut microbiota and sleep disorders with survival among US adult population with diabetes and pre-diabetes

PMCID: PMC12175418 PMID: 40533747 DOI: 10.1186/s12937-025-01162-0 Journal: Nutrition journal Publication Date: 2025-6-18 Authors: Si K, Shi C, Huang Y, Liu C, Chi J, et al. Key Points * High dietary quality combined with no sleep disorders is associated with substantially reduced mortality risk in diabetes/pre-diabetes patients * Participants with

Cardiology

Atrial dysfunction: a contrast-free marker for HFpEF in obese diabetics—insights from comprehensive CMR and serum biomarker analyses

PMCID: PMC12175437 PMID: 40533773 DOI: 10.1186/s12933-025-02808-3 Journal: Cardiovascular diabetology Publication Date: 2025-6-18 Authors: Beyer RE, Müller ML, Doeblin P, Werhahn SM, Chiribiri A, et al. Key Points * Left atrial function metrics provide the most reliable CMR-based differentiation of HFpEF from similar clinical conditions * LA maximum volume showed the

Endocrinology

Rice bran extract attenuates cognitive impairment by enhancing pancreatic β-cell insulin secretion in STZ-induced diabetic rats targeting the PPARγ/PDX1 pathway

PMCID: PMC12178994 PMID: 40536613 DOI: 10.1007/s11011-025-01639-1 Journal: Metabolic brain disease Publication Date: 2025-6-19 Authors: Youssef MM, El-Yamany MF, Abdel-Kader RM, Heikal OA Key Points * RBE treatment significantly restored pancreatic insulin levels and improved β-cell function in diabetic rats * Pancreatic GLUT2 levels increased by 126.495% in RBE-treated diabetic

Endocrinology

Density of ectopic fat depots predict distinct biomarkers of glycemic and insulinemic status in persons with HIV

PMCID: PMC12177074 PMID: 40533477 DOI: 10.1038/s41387-025-00381-y Journal: Nutrition & diabetes Publication Date: 2025-6-18 Authors: Park S, Widmer A, Swartz AZ, Koethe JR, Silver HJ Key Points * PWH with diabetes showed significantly altered tissue densities, with 2.5-fold higher hepatic steatosis prevalence compared to those without diabetes * Myosteatosis was

Endocrinology

Effects of family history and sex on diabetes-related outcome in type 2 diabetes – Analysis from the tyrolean diabetes registry

PMCID: PMC12176189 PMID: 40531860 DOI: 10.1371/journal.pone.0324696 Journal: PloS one Publication Date: 2025-6-18 Authors: Plattner C, Pfeifer B, Sourij H, Vill D, Wiedl M, et al. Key Points * Family history of diabetes is associated with earlier T2D diagnosis (mean age 51.89 vs. 56.59 years) * Increased

Endocrinology

Long‐Term or Recurrent Antibiotic Use in Early Life and the Risk of Type 2 Diabetes: A Population‐Based Prospective Cohort and a Case–Control Study

PMCID: PMC12176498 PMID: 40533417 DOI: 10.1111/1753-0407.70113 Journal: Journal of diabetes Publication Date: 2025-6-18 Authors: Li Z, He Q, He X, Xing X, Fu S, et al. Key Points * Long-term or recurrent antibiotic use during childhood may significantly increase type 2 diabetes risk * 26% higher hazard ratio for

Endocrinology

Stable heritability of type 1 diabetes in a Swedish Nationwide Cohort Study

PMCID: PMC12174315 PMID: 40527903 DOI: 10.1038/s41467-025-60813-2 Journal: Nature communications Publication Date: 2025-6-17 Authors: Wei Y, Andersson T, Liu S, Feychting M, Kuja-Halkola R, et al. Key Points * T1D incidence nearly doubled between 1982-2000, with a hazard ratio of 1.85 (95% CI: 1.65, 2.08) for children