Cardiology

Emulating the EPIC trial using VetCompass primary-care data: causal effects of pimobendan in UK dogs with grade IV/VI heart murmurs

PMCID: PMC12176212 PMID: 40531835 DOI: 10.1371/journal.pone.0325695 Journal: PloS one Publication Date: 2025-6-18 Authors: Pegram C, Diaz-Ordaz K, Brodbelt DC, Chang YM, Boswood A, et al. Key Points * Pimobendan prescription within 6 months of grade IV heart murmur diagnosis reduced 5-year CHF cumulative incidence by 22.2%

Emergency_Medicine

Bystander CPR Technique and Outcomes for Cardiac Arrest With and Without Opioid Toxicity

PMCID: PMC12175020 PMID: 40526383 DOI: 10.1001/jamanetworkopen.2025.16340 Journal: JAMA network open Publication Date: 2025-6-17 Authors: Grunau B, Lee M, Buxton JA, Mok V, Helmer J, et al. Key Points * Bystander CCV-CPR showed statistically significant improved outcomes in opioid-associated out-of-hospital cardiac arrests * The study analyzed a large cohort

Cardiology

ECG Abnormalities and Biomarkers Enable Rapid Risk Stratification in Normotensive Patients With Acute Pulmonary Embolism

PMCID: PMC12178209 PMID: 40536791 DOI: 10.1111/crj.70060 Journal: The clinical respiratory journal Publication Date: 2025-6-19 Authors: Jiao S, Liu Y, He H, Li Q, Wang Z, et al. Key Points * Low QRS voltage on ECG was the strongest independent predictor of in-hospital adverse events (OR: 5.321) * The

Cardiology

Mortality and admissions for cerebrovascular and cardiovascular diseases after the Accumoli-Amatrice 2016 earthquake

PMCID: PMC12176150 PMID: 40531917 DOI: 10.1371/journal.pone.0326242 Journal: PloS one Publication Date: 2025-6-18 Authors: Cadeddu C, Nurchis MC, Castagna C, Sapienza M, Messina R, et al. Key Points * Earthquake exposure was associated with a statistically significant increase in acute myocardial infarction (AMI) mortality * AMI events increased by

Cardiology

Atrial dysfunction: a contrast-free marker for HFpEF in obese diabetics—insights from comprehensive CMR and serum biomarker analyses

PMCID: PMC12175437 PMID: 40533773 DOI: 10.1186/s12933-025-02808-3 Journal: Cardiovascular diabetology Publication Date: 2025-6-18 Authors: Beyer RE, Müller ML, Doeblin P, Werhahn SM, Chiribiri A, et al. Key Points * Left atrial function metrics provide the most reliable CMR-based differentiation of HFpEF from similar clinical conditions * LA maximum volume showed the

Cardiology

The role of transient receptor potential melastatin channels in compressive force‐induced contraction of primary cardiac pericytes

PMCID: PMC12172562 PMID: 40526043 DOI: 10.14814/phy2.70396 Journal: Physiological reports Publication Date: 2025-6-17 Authors: Methner C, Cilento E, Cao Z, Iliff J, Mishra A, et al. Key Points * Cardiac pericytes possess mechanosensitive TRPM4 and TRPM7 channels that contribute to microvascular dysfunction during acute myocardial infarction * TRPM4 inhibition reduced

Anesthesiology

Sedation and analgesia in post-cardiac arrest care: a post hoc analysis of the TTM2 trial

PMCID: PMC12175406 PMID: 40528173 DOI: 10.1186/s13054-025-05461-0 Journal: Critical care (London, England) Publication Date: 2025-6-17 Authors: Ceric A, Dankiewicz J, Cronberg T, Düring J, Moseby-Knappe M, et al. Key Points * Higher propofol doses (Q3: 100.7-153.6 mg/kg) significantly improved functional outcomes and survival * Fentanyl and remifentanil use

Cardiology

Nicotine Exacerbates Arrhythmogenesis in Rabbit Right Ventricular Outflow Tract Triggered by Chronic Obstructive Pulmonary Disease

PMCID: PMC12176695 PMID: 40533933 DOI: 10.1111/jcmm.70664 Journal: Journal of cellular and molecular medicine Publication Date: 2025-6-18 Authors: Chan C, Lin F, Chen Y, Higa S, Chen S, et al. Key Points * COPD and nicotine independently increase ventricular tachycardia risk, with nicotine exacerbating arrhythmogenic potential * 89% of nicotine-treated

Cardiology

Emulating the EPIC trial using VetCompass primary-care data: causal effects of pimobendan in UK dogs with grade IV/VI heart murmurs

PMCID: PMC12176212 PMID: 40531835 DOI: 10.1371/journal.pone.0325695 Journal: PloS one Publication Date: 2025-6-18 Authors: Pegram C, Diaz-Ordaz K, Brodbelt DC, Chang YM, Boswood A, et al. Key Points * Pimobendan prescription within 6 months of grade IV heart murmur diagnosis reduced 5-year CHF cumulative incidence by 22.2%

Emergency_Medicine

Bystander CPR Technique and Outcomes for Cardiac Arrest With and Without Opioid Toxicity

PMCID: PMC12175020 PMID: 40526383 DOI: 10.1001/jamanetworkopen.2025.16340 Journal: JAMA network open Publication Date: 2025-6-17 Authors: Grunau B, Lee M, Buxton JA, Mok V, Helmer J, et al. Key Points * Bystander CCV-CPR showed statistically significant improved outcomes in opioid-associated out-of-hospital cardiac arrests * The study analyzed a large cohort

Cardiology

ECG Abnormalities and Biomarkers Enable Rapid Risk Stratification in Normotensive Patients With Acute Pulmonary Embolism

PMCID: PMC12178209 PMID: 40536791 DOI: 10.1111/crj.70060 Journal: The clinical respiratory journal Publication Date: 2025-6-19 Authors: Jiao S, Liu Y, He H, Li Q, Wang Z, et al. Key Points * Low QRS voltage on ECG was the strongest independent predictor of in-hospital adverse events (OR: 5.321) * The

Cardiology

Mortality and admissions for cerebrovascular and cardiovascular diseases after the Accumoli-Amatrice 2016 earthquake

PMCID: PMC12176150 PMID: 40531917 DOI: 10.1371/journal.pone.0326242 Journal: PloS one Publication Date: 2025-6-18 Authors: Cadeddu C, Nurchis MC, Castagna C, Sapienza M, Messina R, et al. Key Points * Earthquake exposure was associated with a statistically significant increase in acute myocardial infarction (AMI) mortality * AMI events increased by