CurrentMed (Page 7)

Immunology

Research Progress on Inflammation and Immune Dysregulation in PTSD

PMCID: PMC12171638 PMID: 40525295 DOI: 10.1002/brb3.70633 Journal: Brain and behavior Publication Date: 2025-6-17 Authors: Yang L, Lu J, Zhao Z, Zhang Z, Yang W, et al. Key Points * PTSD is characterized by significant immune system dysregulation with consistent pro-inflammatory cytokine elevations * Multiple studies demonstrated increased inflammatory markers

Gastroenterology

An optimized peritonitis-induced ACLF model that reproduces the full spectrum of extrahepatic organ failures in mice

PMCID: PMC12180834 PMID: 40536682 DOI: 10.1097/HC9.0000000000000744 Journal: Hepatology communications Publication Date: 2025-7 Authors: Flores-Costa R, Duran-Güell M, Romero-Grimaldo B, Contreras BJ, Salvatella A, et al. Key Points * First comprehensive murine model reproducing full spectrum of ACLF-associated extrahepatic organ failures * Demonstrated significant increases in inflammatory markers (Il-6, Tnf)

Endocrinology

Joint association of the newly proposed dietary index for gut microbiota and sleep disorders with survival among US adult population with diabetes and pre-diabetes

PMCID: PMC12175418 PMID: 40533747 DOI: 10.1186/s12937-025-01162-0 Journal: Nutrition journal Publication Date: 2025-6-18 Authors: Si K, Shi C, Huang Y, Liu C, Chi J, et al. Key Points * High dietary quality combined with no sleep disorders is associated with substantially reduced mortality risk in diabetes/pre-diabetes patients * Participants with

Surgery

Development of novel thoracic retractor for resuscitative thoracotomy

PMCID: PMC12172248 PMID: 40528231 DOI: 10.1186/s13049-025-01423-1 Journal: Scandinavian journal of trauma, resuscitation and emergency medicine Publication Date: 2025-6-17 Authors: Urabe S, Shimazaki J, Izutani T, Hata T, Uemura M, et al. Key Points * Novel thoracic retractor significantly reduces time required for thoracotomy procedure * Median procedure time reduced by

Radiology

Quantification of the difference in hounsfield units of an electron density phantom between a conventional and standing computed tomography machine

PMCID: PMC12174245 PMID: 40526177 DOI: 10.1007/s11259-025-10789-7 Journal: Veterinary research communications Publication Date: 2025-6-17 Authors: Beck C, Morrice-West AV, Muir P, Hitchens PL, Whitton RC Key Points * HU values varied significantly between conventional and standing CT machines, with the greatest differences in high-density regions * Mean HU values for dense

Cardiology

Mortality and admissions for cerebrovascular and cardiovascular diseases after the Accumoli-Amatrice 2016 earthquake

PMCID: PMC12176150 PMID: 40531917 DOI: 10.1371/journal.pone.0326242 Journal: PloS one Publication Date: 2025-6-18 Authors: Cadeddu C, Nurchis MC, Castagna C, Sapienza M, Messina R, et al. Key Points * Earthquake exposure was associated with a statistically significant increase in acute myocardial infarction (AMI) mortality * AMI events increased by

Pharmacology

Cost-effectiveness analysis of two inhaled antibiotics for stable Bronchiectasis with Pseudomonas aeruginosa infections in China

PMCID: PMC12176172 PMID: 40531911 DOI: 10.1371/journal.pone.0324254 Journal: PloS one Publication Date: 2025-6-18 Authors: Chen W, Chen X, Lai L, Hong B, Zhi C, et al. Key Points * TIS provides a cost-effective alternative to CMS for Bronchiectasis patients with Pseudomonas aeruginosa infections * Cost savings of CNY 41,

Emergency_Medicine

Tracheostomy in COVID-19: A retrospective cohort study of outcomes and mortality predictors in a specialized infectious disease hospital in Brazil

PMCID: PMC12176168 PMID: 40531975 DOI: 10.1371/journal.pone.0326531 Journal: PloS one Publication Date: 2025-6-18 Authors: Accetta AF, Medeiros DM, Diniz Ribeiro MP, Cardoso SW, Ferreira Tavares IC, et al. Key Points * 68% mortality rate among COVID-19 patients undergoing tracheostomy, emphasizing the severity of respiratory complications * Patients over 60

Radiology

Mobile human brain imaging using functional ultrasound

PMCID: PMC12175903 PMID: 40532015 DOI: 10.1126/sciadv.adu9133 Journal: Science advances Publication Date: 2025-6-20 Authors: Soloukey S, Verhoef L, Mastik F, Brown M, Springeling G, et al. Key Points * First demonstration of stable, reproducible functional ultrasound imaging during walking in a human subject with a cranial implant * Consistent brain

Psychiatry

Mental health and health-related quality of life among adults with osteoarthritis: A national population-based study

PMCID: PMC12176145 PMID: 40531897 DOI: 10.1371/journal.pone.0325780 Journal: PloS one Publication Date: 2025-6-18 Authors: Alwhaibi M, Alhawassi TM Key Points * Comorbid depression and anxiety significantly reduce mental health-related quality of life in OA patients * 9.9% of OA patients experience both depression and anxiety, with the most

Immunology

Efficacy of NAMPT inhibition in T-cell acute lymphoblastic leukemia

PMCID: PMC12173385 PMID: 40526635 DOI: 10.1371/journal.pone.0324443 Journal: PloS one Publication Date: 2025-6-17 Authors: Vrana C, Zhang M, Rochette M, Alozie M, Oviedo H, et al. Key Points * NAMPT inhibition represents a promising targeted therapeutic approach for T-ALL * FK866 increased median survival by 39.5 days in

Pulmonology

Multicenter clinical trial for the treatment of obstructive sleep apnea with a non-permanent orthodontic intraoral device in children

PMCID: PMC12174215 PMID: 40526156 DOI: 10.1007/s00431-025-06254-x Journal: European journal of pediatrics Publication Date: 2025-6-17 Authors: Kushida CA, Stevens J, Bennett M, Heit T, Klemp D, et al. Key Points * First FDA-cleared non-permanent orthodontic device specifically designed for pediatric OSA treatment * 61.7% of participants achieved >50% AHI

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