CurrentMed (Page 29)

Surgery

Simulation and comparison of objectively graded microsurgery steps by using a microscope and Symani robotic system by young professionals

PMCID: PMC12174173 PMID: 40526352 DOI: 10.1007/s11701-025-02490-3 Journal: Journal of robotic surgery Publication Date: 2025-6-17 Authors: Wieker H, Brandenburg N, Spille D, Wagner J, Weitkamp JT, et al. Key Points * Young medical professionals can effectively operate both microscope and robotic microsurgical systems without prior specialized training * 95% of participants

Immunology

Lymphocyte immunophenotype in dogs with immune-mediated hematologic disease

PMCID: PMC12173396 PMID: 40526723 DOI: 10.1371/journal.pone.0326341 Journal: PloS one Publication Date: 2025-6-17 Authors: Blois SL, Cuq BY, Bienzle D Key Points * Dogs with IMHD demonstrated significantly lower proportions of CD4+ and CD8+ lymphocytes compared to healthy controls (p < 0.0001) * T regulatory cells were reduced

Pharmacology

Hitting Two Birds With One Stone: Dual Modulation of Brain Carbonic Anhydrases and Histone Deacetylases Boosts Memory Consolidation

PMCID: PMC12174897 PMID: 40528640 DOI: 10.1002/ardp.70020 Journal: Archiv der Pharmazie Publication Date: 2025-6-18 Authors: Costa A, Bozdag M, Renzi G, Rani B, Passani MB, et al. Key Points * Multi-targeted molecular approach shows promise for cognitive impairment treatment * Compounds 12 and 14 demonstrated memory enhancement at doses 10x

Surgery

Unusual causes of perineal trauma in paediatric patients: lessons learned from a high-volume colorectal clinic in a low-and-middle-income country

PMCID: PMC12176936 PMID: 40533567 DOI: 10.1007/s00383-025-06075-x Journal: Pediatric surgery international Publication Date: 2025-6-18 Authors: Palmisani F, Teko K, Bebington C, Brisighelli G Key Points * Traditional enemas represent a significant and underrecognized mechanism of pediatric perineal trauma in low-resource settings * 75% continence rate achieved through surgical reconstruction, with median

Anesthesiology

A structured protocol for Preoperative Progressive Pneumoperitoneum (PPP) in Complex Abdominal Wall Reconstruction (CAWR): our York protocol

PMCID: PMC12174292 PMID: 40526283 DOI: 10.1007/s10029-025-03401-z Journal: Hernia : the journal of hernias and abdominal wall surgery Publication Date: 2025-6-17 Authors: Abbas AA, Ahmad A, McCleary A, Nicholls M, Chitsabesan P, et al. Key Points * First comprehensive, multidisciplinary protocol specifically designed for complex abdominal wall reconstruction * Systematic seven-week perioperative

Public_Health

Use and Perception of Video Consultations Among Swedish Dietitians Before and After COVID‐19 Onset

PMCID: PMC12177270 PMID: 40534156 DOI: 10.1111/jhn.70080 Journal: Journal of human nutrition and dietetics : the official journal of the British Dietetic Association Publication Date: 2025-6-18 Authors: Persson S, Liljegren AE, Olsson C, Rydén P Key Points * Video consultation usage among Swedish Registered Dietitians increased over 300% between 2016

Pharmacology

Multi‐Target Drug Design in Alzheimer's Disease Treatment: Emerging Technologies, Advantages, Challenges, and Limitations

PMCID: PMC12175645 PMID: 40531439 DOI: 10.1002/prp2.70131 Journal: Pharmacology research & perspectives Publication Date: 2025-6-18 Authors: Hossain MS, Hussain MH Key Points * Multi-target drug design offers a more holistic approach to treating Alzheimer's disease by simultaneously addressing multiple pathological mechanisms * Emerging technologies like AI and nanomedicine

Anesthesiology

Efficacy and safety of ciprofol for sedation/anesthesia in patients undergoing hysteroscopy: a prospective, randomized, non-inferiority trial

PMCID: PMC12180349 PMID: 40530830 DOI: 10.1080/07853890.2025.2517820 Journal: Annals of medicine Publication Date: 2025-6-18 Authors: Cheng S, Wu H, Liu Z, Liu D, Cao M, et al. Key Points * Ciprofol demonstrated non-inferior anesthetic efficacy compared to propofol for hysteroscopy * Injection pain was dramatically reduced in ciprofol group

Oncology

Bladder cancer variants share aggressive features including a CA125+ cell state and targetable TM4SF1 expression

PMCID: PMC12174346 PMID: 40527915 DOI: 10.1038/s41467-025-59888-8 Journal: Nature communications Publication Date: 2025-6-17 Authors: Yang H, Song H, Yip E, Gilpatrick T, Chang K, et al. Key Points * HV bladder cancers harbor a unique tumor cell state with distinct molecular characteristics, primarily expressing CA125, MUC4, and KRT24 * CA125+ cells

Gastroenterology

Single-cell dissection of prognostic architecture and immunotherap response in Helicobacter pylori infection-associated gastric cancer

PMCID: PMC12173458 PMID: 40525824 DOI: 10.7554/eLife.99337 Journal: eLife Publication Date: 2025-6-17 Authors: Zhang X, Zhang G, Sang S, Fei Y, Cao X, et al. Key Points * H. pylori infection fundamentally reshapes gastric cancer's tumor microenvironment, increasing inflammatory and angiogenic cellular components * iCAF abundance and angiogenic

Endocrinology

Effects of family history and sex on diabetes-related outcome in type 2 diabetes – Analysis from the tyrolean diabetes registry

PMCID: PMC12176189 PMID: 40531860 DOI: 10.1371/journal.pone.0324696 Journal: PloS one Publication Date: 2025-6-18 Authors: Plattner C, Pfeifer B, Sourij H, Vill D, Wiedl M, et al. Key Points * Family history of diabetes is associated with earlier T2D diagnosis (mean age 51.89 vs. 56.59 years) * Increased