Latest

Surgery

A narrative review and scoring proposal for secondary lumbar instability after lumbar decompression surgery

PMCID: PMC12177027 PMID: 40531241 DOI: 10.1007/s00701-025-06590-9 Journal: Acta neurochirurgica Publication Date: 2025-6-18 Authors: Abramovic A, Lener S, Hartmann S, Thomé C Key Points * A comprehensive 14-point scoring system was developed to predict secondary lumbar instability risk after decompressive surgery * Key risk factors include disc height > 6.5

By Ethan Littlefield

Oncology

Hypoxia‐induced PGK1 expression promotes esophageal squamous cell carcinoma progression via stimulating MYH9‐mediated GSK3β/β‐catenin signalling

PMCID: PMC12177104 PMID: 40534132 DOI: 10.1002/ctm2.70376 Journal: Clinical and translational medicine Publication Date: 2025-6-18 Authors: Xu J, Wu L, Chen T, Liu Y, Zhang Y, et al. Key Points * Elevated PGK1 levels correlate with poor survival and advanced tumor stages in ESCC patients * PGK1 promotes tumor progression

By Ethan Littlefield

Psychiatry

Sexual dysfunction and other prolactin-related side effects of antipsychotic drugs in schizophrenia: Protocol for a systematic review with single-arm, pairwise, and network meta-analyses of randomized controlled trials and non-randomized studies

PMCID: PMC12138325 PMID: 40474917 DOI: 10.12688/f1000research.154742.1 Journal: F1000Research Publication Date: 2025-6-19 Authors: Schneider-Thoma J, Dong S, Kim DD, Efthimiou O, Siafis S, et al. Key Points * Sexual dysfunctions are prevalent in schizophrenia patients, potentially impacting treatment adherence and quality of life * The study will comprehensively analyze

By Ethan Littlefield

Surgery

Influence of pelvic incidence–lumbar lordosis mismatch on surgical outcomes of total hip arthroplasty: a retrospective cohort study

PMCID: PMC12174211 PMID: 40526273 DOI: 10.1007/s00590-025-04383-5 Journal: European journal of orthopaedic surgery & traumatology : orthopedie traumatologie Publication Date: 2025-6-17 Authors: Ishikura H, Nishiwaki T, Kudo M, Minoji S, Tanaka T, et al. Key Points * PI-LL mismatch ≥ 10° is associated with altered spinopelvic parameters and poorer preoperative functional scores

By Ethan Littlefield

Neurology

Mechanistic Pathways Underlying Genetic Predisposition to Atrial Fibrillation Are Associated With Different Cardiac Phenotypes and Cardioembolic Stroke Risk

PMCID: PMC12173164 PMID: 40526779 DOI: 10.1161/CIRCGEN.124.004932 Journal: Circulation. Genomic and precision medicine Publication Date: 2025-6-17 Authors: Gajendragadkar PR, Von Ende A, Murgia F, Offer A, Camm CF, et al. Key Points * Distinct genetic pathways for AF have differential effects on cardiac phenotypes and stroke risk * Muscle

By Ethan Littlefield

Obstetrics_Gynecology

Association of Sleep, Inflammation and Female Infertility: A Cross‐Sectional Survey and Genetic Approach

PMCID: PMC12171637 PMID: 40525280 DOI: 10.1002/brb3.70627 Journal: Brain and behavior Publication Date: 2025-6-17 Authors: Xin X, Li J, Zhang J, Wu H Key Points * Sleep disorders significantly alter inflammatory markers in women of reproductive age * Specific sleep traits (insomnia, sleep efficiency) correlate with inflammatory proteins linked to

By Ethan Littlefield

Oncology

Modulating autophagy in KRAS mutant colorectal cancer using combination of oncolytic reovirus and carbamazepine

PMCID: PMC12173229 PMID: 40526688 DOI: 10.1371/journal.pone.0326029 Journal: PloS one Publication Date: 2025-6-17 Authors: Shaykevich A, Chae D, Silverman I, Goel S, Maitra R Key Points * Carbamazepine and oncolytic reovirus demonstrate synergistic effects in inducing autophagy in KRAS-mutated colorectal cancer cells * Dual treatment significantly increased autophagy-related protein

By Ethan Littlefield

Oncology

AKR1C2 silencing promotes ferroptosis and inhibits proliferation, migration, and invasion in lung cancer cells

PMCID: PMC12176218 PMID: 40531841 DOI: 10.1371/journal.pone.0325995 Journal: PloS one Publication Date: 2025-6-18 Authors: Cui Y, Liu Z Key Points * AKR1C2 expression is significantly higher in lung cancer tissues and correlates with worse patient prognosis * High AKR1C2 expression is associated with increased lymph node metastasis and advanced

By Ethan Littlefield