Immunology
PMCID: PMC12175482 PMID: 40530896 DOI: 10.1002/cam4.70994 Journal: Cancer medicine Publication Date: 2025-6-18 Authors: Wang F, Chen W, Jia Y, He T, Wu S, et al. Key Points * Intestinal microbiota significantly modulates immunotherapy response in colorectal cancer * Specific bacterial strains can enhance CD8+ T cell infiltration and cytotoxicity
Emergency_Medicine
PMCID: PMC12177648 PMID: 40531532 DOI: 10.1001/jamanetworkopen.2025.16582 Journal: JAMA network open Publication Date: 2025-6-18 Authors: Ouchi K, Block SD, Rentz DM, Berry DL, Oelschlager H, et al. Key Points * Nurse-led ED intervention increased clinician-documented serious illness conversations without significant patient-reported engagement * Clinician documentation of SICs increased from
Obstetrics_Gynecology
PMCID: PMC12182189 PMID: 40527566 DOI: 10.1136/bmjopen-2024-094607 Journal: BMJ open Publication Date: 2025 Authors: Whybrow R, Chappell L, Webster L, Girling J, Brown H, et al. Key Points * Women with chronic hypertension experienced limited involvement in birth planning, with only 34.6% of case notes documenting patient participation * Caesarean
Neurology
PMCID: PMC12175199 PMID: 40530831 DOI: 10.1002/hbm.70263 Journal: Human brain mapping Publication Date: 2025-6-18 Authors: Cheng Z, Yang L, Li M, Zhang Q, Li J, et al. Key Points * T2DM patients showed significantly higher iron deposition in caudate and putamen nuclei compared to healthy controls * Higher magnetic susceptibility
Emergency_Medicine
PMCID: PMC12173181 PMID: 40526732 DOI: 10.1371/journal.pone.0326194 Journal: PloS one Publication Date: 2025-6-17 Authors: Sun M, Zhang X, Liu YC, Pei J, Fan H, et al. Key Points * OSA patients represent a distinct, high-acuity subgroup in emergency departments, with unique demographic and clinical characteristics * Adjusted odds ratios
Surgery
PMCID: PMC12175424 PMID: 40533860 DOI: 10.1186/s41065-025-00479-4 Journal: Hereditas Publication Date: 2025-6-18 Authors: Wu X, Cai R, Ye M, Yang X, Sun D, et al. Key Points * Ilizarov periosteal distraction provides a novel mechanotherapeutic approach for AVM-related ischemic ulcers * 75% wound epithelialization achieved within 4 weeks of intervention * Offers
Immunology
PMCID: PMC12177686 PMID: 40534591 DOI: 10.1002/eji.202451233 Journal: European journal of immunology Publication Date: 2025-6-19 Authors: Gjurgjaj A, Conde CD Key Points * Single-cell multiomics provides unprecedented insights into the molecular mechanisms underlying autoimmune diseases * Emerging computational integration and deep-learning tools show promise for disease stratification and drug prioritization
Gastroenterology
PMCID: PMC12174243 PMID: 40528089 DOI: 10.1007/s00384-025-04937-3 Journal: International journal of colorectal disease Publication Date: 2025-6-18 Authors: Mostafa OE, Zaman S, Malik M, Kumar P, Kumar L, et al. Key Points * No significant clinical advantage was observed with extended mesenteric resection compared to conventional resection in Crohn's
Neurology
PMCID: PMC12173837 PMID: 40528277 DOI: 10.1002/alz.70361 Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association Publication Date: 2025-6-17 Authors: Goodwin GJ, Mehrzad S, Cummings JL, Renn BN, Kinney JW, et al. Key Points * Bridge symptoms differ markedly between AD and bvFTD, with
Immunology
PMCID: PMC12179044 PMID: 40536705 DOI: 10.1007/s00262-025-04091-3 Journal: Cancer immunology, immunotherapy : CII Publication Date: 2025-6-19 Authors: Gustafson AM, Dinerman AJ, Hitscherich KJ, Parkhurst MR, Halas H, et al. Key Points * Lung metastases demonstrated superior TIL growth (95%) compared to other resection sites * 51% of TIL harvests showed high neoantigen
Pharmacology
PMCID: PMC12170901 PMID: 40523897 DOI: 10.1038/s41392-025-02274-z Journal: Signal transduction and targeted therapy Publication Date: 2025-6-17 Authors: Ruan DY, Wu HX, Xu Y, Munster PN, Deng Y, et al. Key Points * First study with the highest proportion of Asian mCRC patients receiving a KRAS G12C inhibitor, demonstrating promising anti-tumor
Pharmacology
PMCID: PMC12178312 PMID: 40536902 DOI: 10.1002/vms3.70416 Journal: Veterinary medicine and science Publication Date: 2025-6-19 Authors: Chen C, A‐ga YB, Kuang X, Li Y, Xiang R, et al. Key Points * Palmatine demonstrates rapid absorption and distribution in Partridge Shank chickens following intramuscular administration * Peak plasma concentration of