CurrentMed (Page 10)

Pharmacology

Comparative effectiveness of interventions to facilitate deprescription of benzodiazepines and other sedative hypnotics: systematic review and meta-analysis

PMCID: PMC12171951 PMID: 40527546 DOI: 10.1136/bmj-2024-081336 Journal: BMJ (Clinical research ed.) Publication Date: 2025 Authors: Zeraatkar D, Nagraj SK, Ling M, Jassal T, Kirsh S, et al. Key Points * Patient education and pharmacist-led interventions showed the most promise in facilitating BSH discontinuation * Low-certainty evidence suggests 144 more patients

Endocrinology

Rice bran extract attenuates cognitive impairment by enhancing pancreatic β-cell insulin secretion in STZ-induced diabetic rats targeting the PPARγ/PDX1 pathway

PMCID: PMC12178994 PMID: 40536613 DOI: 10.1007/s11011-025-01639-1 Journal: Metabolic brain disease Publication Date: 2025-6-19 Authors: Youssef MM, El-Yamany MF, Abdel-Kader RM, Heikal OA Key Points * RBE treatment significantly restored pancreatic insulin levels and improved β-cell function in diabetic rats * Pancreatic GLUT2 levels increased by 126.495% in RBE-treated diabetic

Gastroenterology

Importance of the diameter of the mechanical suture in rectal surgery in relation to benign anastomotic stenosis. Cross-sectional observational study

PMCID: PMC12176904 PMID: 40533680 DOI: 10.1007/s10151-025-03157-9 Journal: Techniques in coloproctology Publication Date: 2025-6-18 Authors: Llorach-Perucho N, Cayetano-Paniagua L, Serra-Aracil X Key Points * Postoperative rectal anastomotic stenosis rates range from 2-30%, with surgeons recognizing current rates as clinically significant * 86.1% survey response rate, with 94.3% of surgeons

Infectious_Disease

Animal movement estimation and network-based epidemic modeling: Illustration for the swine industry in Iowa (US)

PMCID: PMC12176235 PMID: 40531924 DOI: 10.1371/journal.pone.0326234 Journal: PloS one Publication Date: 2025-6-18 Authors: Yang Q, Martínez-López B, Moon SA, Gomez-Vazquez JP, Scoglio C Key Points * Synthetic network modeling reveals heterogeneous disease transmission risks across different farm types * Targeted infections at high out-degree farms could potentially cause

Cardiology

Atrial dysfunction: a contrast-free marker for HFpEF in obese diabetics—insights from comprehensive CMR and serum biomarker analyses

PMCID: PMC12175437 PMID: 40533773 DOI: 10.1186/s12933-025-02808-3 Journal: Cardiovascular diabetology Publication Date: 2025-6-18 Authors: Beyer RE, Müller ML, Doeblin P, Werhahn SM, Chiribiri A, et al. Key Points * Left atrial function metrics provide the most reliable CMR-based differentiation of HFpEF from similar clinical conditions * LA maximum volume showed the

Pharmacology

Differing Genetics of Saline and Cocaine Self‐Administration in the Hybrid Mouse Diversity Panel

PMCID: PMC12173464 PMID: 40527326 DOI: 10.1111/gbb.70029 Journal: Genes, brain, and behavior Publication Date: 2025-6-17 Authors: Khan AH, Bagley JR, LaPierre N, Gonzalez‐Figueroa C, Spencer TC, et al. Key Points * 145 unique genetic loci were identified for saline self-administration, indicating complex genetic regulation of behavioral endpoints * Only

Cardiology

The role of transient receptor potential melastatin channels in compressive force‐induced contraction of primary cardiac pericytes

PMCID: PMC12172562 PMID: 40526043 DOI: 10.14814/phy2.70396 Journal: Physiological reports Publication Date: 2025-6-17 Authors: Methner C, Cilento E, Cao Z, Iliff J, Mishra A, et al. Key Points * Cardiac pericytes possess mechanosensitive TRPM4 and TRPM7 channels that contribute to microvascular dysfunction during acute myocardial infarction * TRPM4 inhibition reduced

Oncology

Repurposing MDM2 inhibitor RG7388 for TP53-mutant NSCLC: a p53-independent pyroptotic mechanism via ROS/p-p38/NOXA/caspase-3/GSDME axis

PMCID: PMC12170848 PMID: 40523886 DOI: 10.1038/s41419-025-07770-2 Journal: Cell death & disease Publication Date: 2025-6-17 Authors: Tang G, Cao X, Chen J, Hui F, Xu N, et al. Key Points * RG7388 exhibits potent anti-tumor effects in TP53-mutant NSCLC through a p53-independent mechanism * Significant dose-dependent reduction in cell viability across

Obstetrics_Gynecology

A comparative systematic review and meta-analysis of uterine artery resistance in pregnant women with and without previous history of cesarean section

PMCID: PMC12176234 PMID: 40531956 DOI: 10.1371/journal.pone.0325352 Journal: PloS one Publication Date: 2025-6-18 Authors: Mohazzab A, Mohammadzadeh A, Nikfar B, Masoumi S, Shoraka E, et al. Key Points * A history of cesarean section may be associated with slightly increased uterine artery resistance * Small but statistically significant effect:

Neurology

Longitudinal assessment of cognitive function in testicular cancer patients prior to orchiectomy and 9 months later and associations with tumor markers

PMCID: PMC12174274 PMID: 40526183 DOI: 10.1007/s00520-025-09637-w Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer Publication Date: 2025-6-17 Authors: Højris NF, Frederiksen Y, Agerbæk M, Nielsen SH, Holt M, et al. Key Points * Low prevalence of cognitive impairment (10.3% pre-surgery,

Pharmacology

Treatment with gemcitabine/cisplatin and durvalumab for advanced biliary tract cancer – real-world data from a multicenter German patient population

PMCID: PMC12176970 PMID: 40533571 DOI: 10.1007/s00432-025-06239-1 Journal: Journal of cancer research and clinical oncology Publication Date: 2025-6-18 Authors: Gerhardt F, Müller C, Venerito M, Chater J, Mohr R, et al. Key Points * First real-world validation of ICI-based therapy for advanced biliary tract cancers using gemcitabine/cisplatin and durvalumab

Psychiatry

Longitudinal Suicide Risk in Children and Adolescents With Attention Deficit and Hyperactivity Disorder: A Systematic Review and Meta‐Analysis

PMCID: PMC12177204 PMID: 40534226 DOI: 10.1002/brb3.70618 Journal: Brain and behavior Publication Date: 2025-6-18 Authors: Garas P, Takacs ZK, Balázs J Key Points * Individuals with ADHD have a 3-4 times higher risk of suicidal behaviors compared to non-ADHD populations * Suicide risk varies significantly across ADHD subtypes, with combined

Latest

Comparative effectiveness of interventions to facilitate deprescription of benzodiazepines and other sedative hypnotics: systematic review and meta-analysis

Rice bran extract attenuates cognitive impairment by enhancing pancreatic β-cell insulin secretion in STZ-induced diabetic rats targeting the PPARγ/PDX1 pathway

Importance of the diameter of the mechanical suture in rectal surgery in relation to benign anastomotic stenosis. Cross-sectional observational study

Animal movement estimation and network-based epidemic modeling: Illustration for the swine industry in Iowa (US)

Atrial dysfunction: a contrast-free marker for HFpEF in obese diabetics—insights from comprehensive CMR and serum biomarker analyses

Differing Genetics of Saline and Cocaine Self‐Administration in the Hybrid Mouse Diversity Panel

The role of transient receptor potential melastatin channels in compressive force‐induced contraction of primary cardiac pericytes

Repurposing MDM2 inhibitor RG7388 for TP53-mutant NSCLC: a p53-independent pyroptotic mechanism via ROS/p-p38/NOXA/caspase-3/GSDME axis

A comparative systematic review and meta-analysis of uterine artery resistance in pregnant women with and without previous history of cesarean section

Longitudinal assessment of cognitive function in testicular cancer patients prior to orchiectomy and 9 months later and associations with tumor markers

Treatment with gemcitabine/cisplatin and durvalumab for advanced biliary tract cancer – real-world data from a multicenter German patient population

Longitudinal Suicide Risk in Children and Adolescents With Attention Deficit and Hyperactivity Disorder: A Systematic Review and Meta‐Analysis