Ethan Littlefield - CurrentMed (Page 8)

Gastroenterology

Impeding Quorum Sensing Among the Intestinal Microbiota Impacts the Metastatic Rate of Colorectal Cancer

PMCID: PMC12177794 PMID: 40536191 DOI: 10.1002/cam4.71009 Journal: Cancer medicine Publication Date: 2025-6-19 Authors: Dietz M, Gates TJ, Sikdar R, Subramanian S, Elias MH, et al. Key Points * QQ lactonase treatment demonstrated sex-specific effects on CRC metastasis * Male mice treated with SsoPox showed 0% metastasis compared to 30%

Pharmacology

Plant-Based Diet and Risk of Iron-deficiency Anemia. A Review of the Current Evidence and Implications for Preventive Strategies

PMCID: PMC12174276 PMID: 40528105 DOI: 10.1007/s13668-025-00671-y Journal: Current nutrition reports Publication Date: 2025-6-18 Authors: López-Moreno M, Castillo-García A, Roldán-Ruiz A, Viña I, Bertotti G Key Points * Plant-based diets may activate adaptive physiological mechanisms to optimize non-heme iron absorption * Vegetarian and vegan diets can potentially provide adequate iron intake

Infectious_Disease

Enhanced Surveillance of Sexually Transmitted Infections to Foster a Learning Public Health System

PMCID: PMC12175029 PMID: 40526386 DOI: 10.1001/jamanetworkopen.2025.14308 Journal: JAMA network open Publication Date: 2025-6-17 Authors: Reyes Nieva H, Zucker J, Tucker E, Castor D, Yin MT, et al. Key Points * Demonstrated potential of health information exchanges to enhance regional disease surveillance by integrating diverse data sources * Identified

Surgery

Risk factors for ACL revision failure and optimum graft size for revision anterior cruciate ligament reconstruction

PMCID: PMC12179230 PMID: 40536685 DOI: 10.1007/s00590-025-04381-7 Journal: European journal of orthopaedic surgery & traumatology : orthopedie traumatologie Publication Date: 2025-6-19 Authors: Lu VY, Lee DH, Tsui SH, Lo TC, Chau WW, et al. Key Points * Graft diameter < 9 mm significantly increases re-rupture risk in revision ACLR * 16.7%

Oncology

Thermal ablation for pulmonary oligometastases from hepatocellular carcinoma: initial experience and retrospective study

PMCID: PMC12177983 PMID: 40533817 DOI: 10.1186/s40644-025-00896-8 Journal: Cancer imaging : the official publication of the International Cancer Imaging Society Publication Date: 2025-6-18 Authors: Hou R, Zhou X, Li Y, Qin Y, Song M, et al. Key Points * Thermal ablation achieved 100% technical success with 96.8% technical efficacy in

Surgery

More harm than good? Parental perspectives on dilatations in anorectal malformations

PMCID: PMC12178956 PMID: 40536563 DOI: 10.1007/s00383-025-06070-2 Journal: Pediatric surgery international Publication Date: 2025-6-19 Authors: Barros AI, Correia MR, Carvalho F, Bonet B, Carvalho C Key Points * 62.5% of caregivers reported emotional distress during anal dilations * 54.2% of parents experienced difficulty performing home-based anal dilations * The study

Surgery

A fast and easy-to-perform noninvasive Muller’s muscle sublimation technique using plasma technology for treatment of mild-to-moderate ptosis: a case report

PMCID: PMC12175309 PMID: 40528246 DOI: 10.1186/s13256-025-05330-y Journal: Journal of medical case reports Publication Date: 2025-6-17 Authors: Raffati N Key Points * Plasma scalpel technology offers a promising minimally invasive alternative for ptosis correction * Mean MRD1 improvement of 2.08 mm across all patients, indicating effective lid elevation * Potential to

Pharmacology

Multimodal CustOmics: A unified and interpretable multi-task deep learning framework for multimodal integrative data analysis in oncology

PMCID: PMC12173418 PMID: 40526743 DOI: 10.1371/journal.pcbi.1013012 Journal: PLoS computational biology Publication Date: 2025-6-17 Authors: Benkirane H, Vakalopoulou M, Planchard D, Adam J, Olaussen K, et al. Key Points * Multimodal CustOmics achieved superior predictive performance across multiple cancer types, with classification AUC consistently above 98% when integrating

Nephrology

Efficacy of Nrf2 activation in a proteinuric Alport syndrome mouse model

PMCID: PMC12174586 PMID: 40527586 DOI: 10.26508/lsa.202503330 Journal: Life science alliance Publication Date: 2025-6-17 Authors: Kaseda S, Horizono J, Sannomiya Y, Kuwazuru J, Suico MA, et al. Key Points * UD-051, a novel Keap1-Nrf2 protein interaction inhibitor, demonstrated kidney protective effects in Alport syndrome by targeting tubular injury * Combination

Immunology

CAR‐NK, a Splendid Strategy for Cancer, Especially for Gynecologic Tumor

PMCID: PMC12171998 PMID: 40525700 DOI: 10.1002/iid3.70210 Journal: Immunity, inflammation and disease Publication Date: 2025-6-17 Authors: Cao Y, Wang L, Wang L Key Points * CAR-NK cells provide a safer, more adaptable immunotherapy alternative to CAR-T cells * Potential for "off-the-shelf" manufacturing reduces personalization complexity and treatment time

Pharmacology

Perceptions of chemoprevention among individuals at high risk of oral cancer: qualitative study within the UK-based SAVER trial

PMCID: PMC12182162 PMID: 40527552 DOI: 10.1136/bmjopen-2025-101326 Journal: BMJ open Publication Date: 2025 Authors: Sherratt F, McCarthy C, Jiménez-Tomàs A, Perry J, Kuruvilla R, et al. Key Points * Individuals with oral epithelial dysplasia are generally open to chemoprevention research, motivated by potential cancer risk reduction * Most participants (11/20)

Pulmonology

Risk Factors and Long‐Term Prognosis for Coinfection of Nontuberculous Mycobacterial Pulmonary Disease and Chronic Pulmonary Aspergillosis: A Multicentre Observational Study in Japan

PMCID: PMC12178108 PMID: 40536274 DOI: 10.1111/myc.70083 Journal: Mycoses Publication Date: 2025-6-19 Authors: Tanaka Y, Ide S, Takazono T, Takeda K, Iwanaga N, et al. Key Points * CPA coinfection occurs in 3.5% of NTM-PD patients, with Aspergillus fumigatus being the most common causative species * Male sex, COPD,