Ethan Littlefield - CurrentMed (Page 5)

Psychiatry

A one-arm pilot trial of a telehealth CBT-based group intervention targeting transdiagnostic risk for emotional distress

PMCID: PMC12176177 PMID: 40531853 DOI: 10.1371/journal.pone.0303131 Journal: PloS one Publication Date: 2025-6-18 Authors: Flynt S, Cho GY, Koscinski B, Accorso C, Knapp A, et al. Key Points * Telehealth-delivered modular CBT intervention shows potential for addressing transdiagnostic mental health risk factors * 85% participant retention rate and high

Pharmacology

[18F]FET PET-Guided management of pseudoprogression in glioblastoma (FET POPPING): the study protocol for a diagnostic randomized clinical trial

PMCID: PMC12175455 PMID: 40528226 DOI: 10.1186/s13063-025-08921-8 Journal: Trials Publication Date: 2025-6-17 Authors: Ruijters VJ, Snijders TJ, van der Pol JA, van de Giessen EM, Niers JM, et al. Key Points * First comprehensive randomized trial investigating FET PET's utility in differentiating pseudoprogression from true tumor progression in

Neurology

The neurobiological foundation of effective repetitive transcranial magnetic brain stimulation in Alzheimer's disease

PMCID: PMC12175030 PMID: 40530618 DOI: 10.1002/alz.70337 Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association Publication Date: 2025-6-18 Authors: Antonioni A, Martorana A, Santarnecchi E, Hampel H, Koch G Key Points * rTMS demonstrates comprehensive neurobiological modulation in AD, targeting synaptic, molecular, and

Endocrinology

Placental inflammation is increased in gestational diabetes mellitus: The role of inflammasome NLRP-3 and chemokine scavenger decoy receptor D6

PMCID: PMC12173348 PMID: 40526637 DOI: 10.1371/journal.pone.0326087 Journal: PloS one Publication Date: 2025-6-17 Authors: Onori M, Beneduce G, Colella F, Lucchetti D, Policola C, et al. Key Points * GDM is characterized by elevated pro-inflammatory cytokines and increased NLRP-3 inflammasome expression * Statistically significant differences observed: CCL-2 (p <

Gastroenterology

The Effect of Postoperative Antithrombin Supplementation on the Inflammatory and Coagulation Status of a Surgically Treated Patient With a Malignant Tumor in the Small Pelvis—Case Series

PMCID: PMC12177226 PMID: 40534446 DOI: 10.1002/cnr2.70260 Journal: Cancer reports (Hoboken, N.J.) Publication Date: 2025-6-19 Authors: Lazović R, Šarenac O Key Points * Antithrombin supplementation can effectively normalize coagulation and inflammatory responses in complex surgical patients * Observed 50-70% reduction in inflammatory markers (IL-6, CRP) within 4 postoperative days

Immunology

Measuring cytokines in Eurasian tundra reindeer (Rangifer tarandus tarandus) with a bovine bead-based multiplex immunoassay and real-time PCR

PMCID: PMC12175305 PMID: 40533814 DOI: 10.1186/s13028-025-00819-4 Journal: Acta veterinaria Scandinavica Publication Date: 2025-6-18 Authors: Frøvoll TL, Lybeck K, Lund H, Makvandi-Nejad S, Grimholt U, et al. Key Points * First comprehensive evaluation of cytokine detection methods specifically for reindeer immunology * Successfully measured inflammatory cytokines using a cross-species multiplex assay,

Endocrinology

Cardiac structure and function across the continuum of glucose metabolism

PMCID: PMC12172345 PMID: 40526029 DOI: 10.14814/phy2.70429 Journal: Physiological reports Publication Date: 2025-6-17 Authors: Grönlund T, Kaikkonen K, Junttila MJ, Ukkola O, Kerkelä R, et al. Key Points * Higher HbA1c levels within normal and prediabetic ranges are associated with decreased myocardial contractility * Proportion of subjects with abnormal global

Infectious_Disease

Influenza Epidemiology in Finland During and After the COVID‐19 Pandemic: Surveillance Data Analysis (2019–2024)

PMCID: PMC12174475 PMID: 40528677 DOI: 10.1111/irv.70131 Journal: Influenza and other respiratory viruses Publication Date: 2025-6-17 Authors: Baum U, Ikonen N, Luomala O, Poukka E, Leino T, et al. Key Points * COVID-19 containment measures effectively suppressed influenza transmission, creating a unique epidemiological "natural experiment" * Vaccine effectiveness

Oncology

N6-methyladenosine-modified GPX2 impacts cancer cell stemness and TKI resistance through regulating of redox metabolism

PMCID: PMC12177039 PMID: 40533443 DOI: 10.1038/s41419-025-07764-0 Journal: Cell death & disease Publication Date: 2025-6-18 Authors: Yang X, Yu L, Shao M, Yang H, Qi K, et al. Key Points * GPX2 serves as a critical mediator of EGFR-TKI resistance in NSCLC by modulating cellular redox balance * Knockdown of GPX2

Surgery

Higher revision and secondary surgery rates after ACL reconstruction in athletes under 16 compared to those over 16: a case-control study

PMCID: PMC12172342 PMID: 40528219 DOI: 10.1186/s13018-025-05935-5 Journal: Journal of orthopaedic surgery and research Publication Date: 2025-6-17 Authors: Tátrai M, Halasi T, Tállay A, Tátrai A, Karácsony AF, et al. Key Points * Adolescent athletes under 16 have a 44% total secondary surgery rate compared to 21% in older patients

Radiology

Using radiomics model for predicting extraprostatic extension with PSMA PET/CT studies: a comparative study with the Mehralivand grading system

PMCID: PMC12177976 PMID: 40533824 DOI: 10.1186/s40644-025-00894-w Journal: Cancer imaging : the official publication of the International Cancer Imaging Society Publication Date: 2025-6-18 Authors: Bian L, Liu F, Peng Y, Liu X, Li P, et al. Key Points * Radiomics model using PSMA PET/CT demonstrates superior EPE prediction compared to

Emergency_Medicine

Potential Diagnostic Error for Emergency Conditions, Mortality, and Healthy Days at Home

PMCID: PMC12175027 PMID: 40526380 DOI: 10.1001/jamanetworkopen.2025.16400 Journal: JAMA network open Publication Date: 2025-6-17 Authors: Lin MP, Burke RC, Sabbatini AK, Latsko E, Edlow JA, et al. Key Points * Potential diagnostic error rate of 3.2% across emergency hospitalizations in Medicare beneficiaries * Potential diagnostic errors associated with