Ethan Littlefield - CurrentMed (Page 4)

Radiology

Advancing Tumor Budding Detection With Fourier Ptychography Microscopy

PMCID: PMC12175198 PMID: 40530892 DOI: 10.1002/cam4.70989 Journal: Cancer medicine Publication Date: 2025-6-18 Authors: Su Y, Sun R, Wang Y, xi Y, Zhang S Key Points * FPM enables digital refocusing and marker removal without physical slide manipulation * 100% diagnostic accuracy achieved using a simplified microscopy approach * Potential to

Immunology

ORM1 Mediates Ln-IgG-Induced Podocyte Damage and Autophagy via the AMPK/mTOR Signaling

PMCID: PMC12184165 PMID: 40526157 DOI: 10.1080/15476278.2025.2519614 Journal: Organogenesis Publication Date: 2025-6-17 Authors: Chen J, Zou L, Liu L, Wu C, Hu M Key Points * ORM1 plays a critical role in podocyte damage and autophagy in lupus nephritis * ORM1 knockdown increased podocyte viability by approximately 40% and

Oncology

PI3K-dependent GAB1/Erk phosphorylation renders head and neck squamous cell carcinoma sensitive to PI3Kα inhibitors

PMCID: PMC12177050 PMID: 40533463 DOI: 10.1038/s41419-025-07767-x Journal: Cell death & disease Publication Date: 2025-6-18 Authors: Zhang X, Xu J, Wang X, Xu L, Zhang X, et al. Key Points * CYH33 demonstrates potent anti-proliferative activity against HNSCC, including cisplatin-resistant cell lines * Achieved significant tumor growth inhibition in xenograft models

Neurology

p‐Cresol and p‐Cresyl Sulphate Boost Oxidative Stress: A Systematic Review of Recent Evidence

PMCID: PMC12177445 PMID: 40534235 DOI: 10.1111/bcpt.70065 Journal: Basic & clinical pharmacology & toxicology Publication Date: 2025-6-18 Authors: Renaldi R, Wiguna T, Persico AM, Tanra AJ Key Points * p-Cresol and PCS induce oxidative stress through NADPH oxidase activation, with potential implications for neurological and metabolic disorders * Concentrations as

Oncology

The impact of de novo lipogenesis on predicting survival and clinical therapy: an exploration based on a multigene prognostic model in hepatocellular carcinoma

PMCID: PMC12178006 PMID: 40533802 DOI: 10.1186/s12967-025-06704-y Journal: Journal of translational medicine Publication Date: 2025-6-18 Authors: Zhou X, Cui G, Hu E, Wang X, Tang D, et al. Key Points * A six-gene DNL signature effectively stratifies HCC patients into distinct prognostic risk groups * Predictive model shows high accuracy with

Oncology

ESRP1 exerts anti-tumor role by promoting ferroptosis in diffuse-type gastric cancer

PMCID: PMC12175430 PMID: 40528239 DOI: 10.1186/s13046-025-03435-2 Journal: Journal of experimental & clinical cancer research : CR Publication Date: 2025-6-18 Authors: Xu K, Chen H, Zhu X, Li H, Liu X, et al. Key Points * High ESRP1 expression is an independent prognostic factor for improved survival in diffuse-type gastric cancer

Oncology

EGFRvIII-positive glioblastoma contributes to immune escape and malignant progression via the c-Fos-MDK-LRP1 axis

PMCID: PMC12174314 PMID: 40527884 DOI: 10.1038/s41419-025-07771-1 Journal: Cell death & disease Publication Date: 2025-6-17 Authors: Yuan F, Wang Y, Yuan L, Tang T, Ye L, et al. Key Points * EGFRvIII mutation is associated with higher WHO grade 4 gliomas (93.3% vs. 53.6%, p=0.044) * M2

Gastroenterology

Neurological Manifestations of HEV Infection: A Rare Phenomenon or an Underrecognized Reality?

PMCID: PMC12177195 PMID: 40534221 DOI: 10.1002/brb3.70585 Journal: Brain and behavior Publication Date: 2025-6-18 Authors: Iza M, Ramos D, Llauradó A, Restrepo‐Vera JL, Pallero M, et al. Key Points * HEV can cause diverse neurological manifestations, including neuralgic amyotrophy and meningoradiculitis, in immunocompetent patients * Initial HEV viral loads

Neurology

Influences of Gait Training with Knee–Ankle–Foot Orthosis on Gait Ability and Independence in Severe Hemiplegia and Pusher Behavior with Unilateral Spatial Neglect Following Stroke: A Retrospective Historical Controlled Study

PMCID: PMC12177197 PMID: 40534213 DOI: 10.1002/brb3.70535 Journal: Brain and behavior Publication Date: 2025-6-18 Authors: Sawa K, Tamura M, Arai S Key Points * Long-term KAFO intervention showed differential improvements across stroke patient subgroups * Days since stroke onset and sensorimotor variability were critical predictors of gait independence (p <

Endocrinology

Stable heritability of type 1 diabetes in a Swedish Nationwide Cohort Study

PMCID: PMC12174315 PMID: 40527903 DOI: 10.1038/s41467-025-60813-2 Journal: Nature communications Publication Date: 2025-6-17 Authors: Wei Y, Andersson T, Liu S, Feychting M, Kuja-Halkola R, et al. Key Points * T1D incidence nearly doubled between 1982-2000, with a hazard ratio of 1.85 (95% CI: 1.65, 2.08) for children

Obstetrics_Gynecology

Divergence in the sow vaginal microbiota is associated with fertility

PMCID: PMC12177788 PMID: 40470844 DOI: 10.1530/REP-25-0044 Journal: Reproduction (Cambridge, England) Publication Date: 2025-6-18 Authors: Fletcher L, Zhan X, Song Y, Li J Key Points * Vaginal microbiota composition shows promise as a novel biomarker for predicting sow fertility * Machine learning model achieved 93.3% accuracy in classifying reproductive performance

Cardiology

Emulating the EPIC trial using VetCompass primary-care data: causal effects of pimobendan in UK dogs with grade IV/VI heart murmurs

PMCID: PMC12176212 PMID: 40531835 DOI: 10.1371/journal.pone.0325695 Journal: PloS one Publication Date: 2025-6-18 Authors: Pegram C, Diaz-Ordaz K, Brodbelt DC, Chang YM, Boswood A, et al. Key Points * Pimobendan prescription within 6 months of grade IV heart murmur diagnosis reduced 5-year CHF cumulative incidence by 22.2%