Ethan Littlefield - CurrentMed (Page 31)

Pathology

Epithelial zinc finger protein in lung adenocarcinoma: prognostic biomarker with molecular and clinical implications

PMCID: PMC12175355 PMID: 40533866 DOI: 10.1186/s41065-025-00476-7 Journal: Hereditas Publication Date: 2025-6-18 Authors: Wen X, Zhu J, Xi D, Chen M, Zeng D, et al. Key Points * EZF expression is significantly downregulated in lung adenocarcinoma, yet correlates with advanced tumor progression * High-risk patients with low EZF expression showed 1.

Public_Health

Use of community-based surveillance to enhance emerging infectious disease intelligence generation in Indonesia

PMCID: PMC12178592 PMID: 40537055 DOI: 10.7189/jogh.15.04118 Journal: Journal of global health Publication Date: 2025-6-20 Authors: Craig AT, Japri AP, Heryanto B Key Points * CBS in Indonesia represents a potentially transformative approach to early warning disease surveillance, bridging community engagement with epidemiological monitoring * No standardized performance metrics

Oncology

Genetic characteristics of blastic plasmacytoid dendritic cell neoplasm: A single institution experience

PMCID: PMC12173198 PMID: 40526100 DOI: 10.18632/oncotarget.28742 Journal: Oncotarget Publication Date: 2025 Authors: Fei F, Telatar M, Tomasian V, Chang L, Danilova O, et al. Key Points * TET2 and ASXL1 mutations were predominant, occurring in 57% and 33% of BPDCN cases, respectively * Patients with ≥3 mutations and TET2

Oncology

A multi-gene predictive model for the radiation sensitivity of nasopharyngeal carcinoma based on machine learning

PMCID: PMC12176387 PMID: 40530955 DOI: 10.7554/eLife.99849 Journal: eLife Publication Date: 2025-6-18 Authors: Li K, Liang J, Li N, Fang J, Zhou X, et al. Key Points * NPC-RSS provides a robust, data-driven approach to predicting radiotherapy response in nasopharyngeal carcinoma * Model achieved high predictive accuracy with AUC of

Oncology

The Prognosis Prediction Model for Endometrial Cancer Based on DNA Methylation Signature

PMCID: PMC12174473 PMID: 40528483 DOI: 10.1002/cnr2.70218 Journal: Cancer reports (Hoboken, N.J.) Publication Date: 2025-6-17 Authors: Ran R, Wang M, Miao J Key Points * Identified 11 key genes (including POU4F3, MAL, MAGI2) that play critical roles in endometrial cancer progression through epigenetic dysregulation * Recurrence model AUC values:

Public_Health

Expansion and Marketing of Medicare Advantage to Persons With End-Stage Kidney Disease

PMCID: PMC12175025 PMID: 40526382 DOI: 10.1001/jamanetworkopen.2025.16359 Journal: JAMA network open Publication Date: 2025-6-17 Authors: Brazier JF, Trivedi AN, Tyler DA, Shield RR, Gadbois EA Key Points * MA plans offer expanded coverage for ESKD patients, but marketing often obscures critical limitations in care * Open enrollment marketing can

Emergency_Medicine

Cleared to land? A nationwide analysis of emergency care hospital and HEMS infrastructure in Germany

PMCID: PMC12175417 PMID: 40528175 DOI: 10.1186/s13049-025-01418-y Journal: Scandinavian journal of trauma, resuscitation and emergency medicine Publication Date: 2025-6-17 Authors: Wolff J, Hohenstein C, Karagiannidis C, Kerkhoff J, Lossius HM, et al. Key Points * Only 44% of emergency care hospitals have certified helipads, compromising potential rapid medical interventions * 30.

Cardiology

Nicotine Exacerbates Arrhythmogenesis in Rabbit Right Ventricular Outflow Tract Triggered by Chronic Obstructive Pulmonary Disease

PMCID: PMC12176695 PMID: 40533933 DOI: 10.1111/jcmm.70664 Journal: Journal of cellular and molecular medicine Publication Date: 2025-6-18 Authors: Chan C, Lin F, Chen Y, Higa S, Chen S, et al. Key Points * COPD and nicotine independently increase ventricular tachycardia risk, with nicotine exacerbating arrhythmogenic potential * 89% of nicotine-treated

Immunology

TIGIT blockade improves anti-Mycobacterium tuberculosis immunity

PMCID: PMC12173411 PMID: 40526725 DOI: 10.1371/journal.ppat.1013228 Journal: PLoS pathogens Publication Date: 2025-6-17 Authors: Zhou J, Yang Q, Xu H, Chen H, Jiang N, et al. Key Points * TIGIT expression on CD8+ T cells is significantly elevated in active TB patients and correlates with disease severity * TIGIT

Immunology

Immune checkpoint inhibitors in cancer therapy: what lies beyond monoclonal antibodies?

PMCID: PMC12178997 PMID: 40536609 DOI: 10.1007/s12032-025-02822-1 Journal: Medical oncology (Northwood, London, England) Publication Date: 2025-6-19 Authors: Zamani MR, Šácha P Key Points * Non-antibody immune checkpoint inhibitors represent a promising frontier in cancer immunotherapy, offering more targeted and potentially less toxic treatment approaches * Multiple novel ICI candidates are currently

Public_Health

“There’s just such a mismatch”: a qualitative exploration of health systems and organizational-level barriers to accessing cancer services among people experiencing structural marginalization

PMCID: PMC12177988 PMID: 40533755 DOI: 10.1186/s12939-025-02554-8 Journal: International journal for equity in health Publication Date: 2025-6-18 Authors: Horrill TC, Crawford J, Beck S, Bourgeois A, Kaur J, et al. Key Points * Cancer service design systematically disadvantages patients experiencing structural marginalization * 59% of patient participants self-identified as Indigenous, highlighting

Oncology

Molecular landscape of HER2-mutated non-small cell lung cancer in Northeastern Brazil: Clinical, histopathological, and genomic insights

PMCID: PMC12173199 PMID: 40526089 DOI: 10.18632/oncotarget.28737 Journal: Oncotarget Publication Date: 2025 Authors: Nogueira CD, Frota S, Chaves HL, de Sousa JC, Veloso GD, et al. Key Points * HER2 mutations were identified in 4.9% of NSCLC cases, with exon 20 insertions being the most prevalent * The DESTINY-Lung01