Ethan Littlefield - CurrentMed (Page 30)

Anesthesiology

Sedation and analgesia in post-cardiac arrest care: a post hoc analysis of the TTM2 trial

PMCID: PMC12175406 PMID: 40528173 DOI: 10.1186/s13054-025-05461-0 Journal: Critical care (London, England) Publication Date: 2025-6-17 Authors: Ceric A, Dankiewicz J, Cronberg T, Düring J, Moseby-Knappe M, et al. Key Points * Higher propofol doses (Q3: 100.7-153.6 mg/kg) significantly improved functional outcomes and survival * Fentanyl and remifentanil use

Pharmacology

Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acids: advances and challenges

PMCID: PMC12178025 PMID: 40533746 DOI: 10.1186/s12951-025-03528-2 Journal: Journal of nanobiotechnology Publication Date: 2025-6-18 Authors: Sanadgol N, Abedi M, Hashemzaei M, Kamran Z, Khalseh R, et al. Key Points * Exosomes provide a safer, more controllable alternative to cell-based therapies, eliminating risks like teratoma formation * Emerging strategies like cell-penetrating peptide

Pathology

Targeting Oncofoetal Chondroitin Sulphate Allows Identification of Tumour‐Derived Extracellular Vesicles

PMCID: PMC12173530 PMID: 40527727 DOI: 10.1002/jev2.70106 Journal: Journal of extracellular vesicles Publication Date: 2025-6-17 Authors: Enciso‐Martinez A, Løppke C, Koene JJ, Ebbelaar J, van der Geest M, et al. Key Points * First comprehensive method for specifically identifying tumor-derived extracellular vesicles using oncofoetal chondroitin sulphate * Demonstrated ofCS

Obstetrics_Gynecology

Antenatal identification of early- and late-onset fetal growth restriction and the possible impact of the introduction of cerebroplacental ratio: Effect on perinatal and childhood outcome

PMCID: PMC12176146 PMID: 40531933 DOI: 10.1371/journal.pone.0325906 Journal: PloS one Publication Date: 2025-6-18 Authors: Hertting E, Herling L, Lindqvist PG, Wiberg-Itzel E Key Points * Antenatal identification of early-onset FGR reduces stillbirth risk but increases risks of severe newborn and childhood outcomes * Early-onset FGR identification associated with 81%

Oncology

The DCDC2/ENO1 axis promotes tumor progression and immune evasion in intrahepatic cholangiocarcinoma via activating FGL1-LAG3 checkpoint

PMCID: PMC12175362 PMID: 40533767 DOI: 10.1186/s13046-025-03436-1 Journal: Journal of experimental & clinical cancer research : CR Publication Date: 2025-6-18 Authors: Wan W, Li Y, Sun W, Cheng Z, Ma F, et al. Key Points * Anti-DCDC2 autoantibodies emerge as a potential novel diagnostic biomarker for intrahepatic cholangiocarcinoma * DCDC2 promotes ICC

Pulmonology

Assessment of ventilation heterogeneity in severe asthma using phase‐resolved functional lung magnetic resonance imaging

PMCID: PMC12177108 PMID: 40534189 DOI: 10.14814/phy2.70423 Journal: Physiological reports Publication Date: 2025-6-18 Authors: Foo CT, Langton D, Donovan GM, Thompson BR, Noble PB, et al. Key Points * PREFUL MRI revealed significantly higher ventilation defect percentages in severe asthma patients (19.9% vs. 1.9% in healthy volunteers)

Surgery

Robotic Submesocolic Left Adrenalectomy: The Evolution of Delbet Approach

PMCID: PMC12172399 PMID: 40525778 DOI: 10.1002/rcs.70080 Journal: The international journal of medical robotics + computer assisted surgery : MRCAS Publication Date: 2025-6-17 Authors: Ortenzi M, Santini A, Balla A, Corallino D, Lezoche G, et al. Key Points * Robotic submesocolic approach demonstrates safety and feasibility for left adrenalectomy * Operative time

Public_Health

Experiences of postnatal contraceptive care during the COVID-19 pandemic: a multimethods cross-sectional study

PMCID: PMC12182104 PMID: 40527556 DOI: 10.1136/bmjopen-2024-095608 Journal: BMJ open Publication Date: 2025 Authors: Kelly S, Moffat M, Thompson C, Jackowich R, Möller-Christensen C, et al. Key Points * Women who delivered in 2020 had significantly fewer postnatal healthcare provider contacts compared to 2021-2022 cohorts * Only 42.7% of women

Pathology

A three dimensional immunolabeling method with peroxidase-fused nanobodies and fluorochromized tyramide-glucose oxidase signal amplification

PMCID: PMC12177075 PMID: 40533487 DOI: 10.1038/s42003-025-08317-z Journal: Communications biology Publication Date: 2025-6-18 Authors: Yamauchi K, Koike M, Hioki H Key Points * Nanobody-based 3D-IHC technique provides superior tissue penetration compared to conventional antibodies * Achieved 9.0-fold signal amplification compared to standard fluorescence imaging * Enables multiplex molecular imaging in thick

Pathology

Deep learning for differential diagnosis of parotid tumors based on 2.5D magnetic resonance imaging

PMCID: PMC12180351 PMID: 40531801 DOI: 10.1080/07853890.2025.2520401 Journal: Annals of medicine Publication Date: 2025-6-18 Authors: Mai W, Fan X, Zhang L, Li J, Chen L, et al. Key Points * 2.5D deep learning approach significantly improves diagnostic accuracy of parotid gland tumors * Model achieved AUC of 0.

Infectious_Disease

Use of JYNNEOS (Smallpox and Mpox Vaccine, Live, Nonreplicating) for Persons Aged ≥18 Years at Risk for Mpox During an Mpox Outbreak: Recommendations of the Advisory Committee on Immunization Practices — United States, 2023

PMCID: PMC12176103 PMID: 40531798 DOI: 10.15585/mmwr.mm7422a3 Journal: MMWR. Morbidity and mortality weekly report Publication Date: 2025-6-19 Authors: Rao AK, Minhaj FS, Carter RJ, Duffy J, Satheshkumar PS, et al. Key Points * JYNNEOS is safe and recommended for diverse populations, including those with atopic dermatitis, immunocompromising conditions, and

Pharmacology

A Double‐Blind Randomised Clinical Trial of Terbinafine‐Nanostructured Lipid Carriers: Should We Anticipate This Strategy for Effective Topical Treatment of Onychomycosis?

PMCID: PMC12171949 PMID: 40525269 DOI: 10.1111/myc.70076 Journal: Mycoses Publication Date: 2025-6-17 Authors: Parsay S, Saeedi M, Abastabar M, Hedayati MT, Rahimnia SM, et al. Key Points * Nanostructured lipid carriers enabled a more targeted and efficient delivery of terbinafine for onychomycosis treatment * Clinical severity index reduction of 45%