Ethan Littlefield - CurrentMed (Page 3)

Immunology

Extensive Clinical Flow Cytometric Lymphocyte Phenotyping in Myasthenia Gravis: A Single‐Center Study

PMCID: PMC12172393 PMID: 40525756 DOI: 10.1111/jnc.70126 Journal: Journal of neurochemistry Publication Date: 2025-6-17 Authors: Lindahl H, Petersson M, Enoksson SL, Piehl F, Brauner S Key Points * Untreated MG patients show distinctive lymphocyte subset alterations, particularly elevated CD4 T cell frequencies * High CD4 T cell percentages (>75%

Surgery

Influence of pelvic incidence–lumbar lordosis mismatch on surgical outcomes of total hip arthroplasty: a retrospective cohort study

PMCID: PMC12174211 PMID: 40526273 DOI: 10.1007/s00590-025-04383-5 Journal: European journal of orthopaedic surgery & traumatology : orthopedie traumatologie Publication Date: 2025-6-17 Authors: Ishikura H, Nishiwaki T, Kudo M, Minoji S, Tanaka T, et al. Key Points * PI-LL mismatch ≥ 10° is associated with altered spinopelvic parameters and poorer preoperative functional scores

Neurology

Mechanistic Pathways Underlying Genetic Predisposition to Atrial Fibrillation Are Associated With Different Cardiac Phenotypes and Cardioembolic Stroke Risk

PMCID: PMC12173164 PMID: 40526779 DOI: 10.1161/CIRCGEN.124.004932 Journal: Circulation. Genomic and precision medicine Publication Date: 2025-6-17 Authors: Gajendragadkar PR, Von Ende A, Murgia F, Offer A, Camm CF, et al. Key Points * Distinct genetic pathways for AF have differential effects on cardiac phenotypes and stroke risk * Muscle

Obstetrics_Gynecology

Association of Sleep, Inflammation and Female Infertility: A Cross‐Sectional Survey and Genetic Approach

PMCID: PMC12171637 PMID: 40525280 DOI: 10.1002/brb3.70627 Journal: Brain and behavior Publication Date: 2025-6-17 Authors: Xin X, Li J, Zhang J, Wu H Key Points * Sleep disorders significantly alter inflammatory markers in women of reproductive age * Specific sleep traits (insomnia, sleep efficiency) correlate with inflammatory proteins linked to

Oncology

AKR1C2 silencing promotes ferroptosis and inhibits proliferation, migration, and invasion in lung cancer cells

PMCID: PMC12176218 PMID: 40531841 DOI: 10.1371/journal.pone.0325995 Journal: PloS one Publication Date: 2025-6-18 Authors: Cui Y, Liu Z Key Points * AKR1C2 expression is significantly higher in lung cancer tissues and correlates with worse patient prognosis * High AKR1C2 expression is associated with increased lymph node metastasis and advanced

Surgery

Ultra-massive fluid transfusion in adult liver transplant recipients: A single center observational study

PMCID: PMC12173374 PMID: 40526696 DOI: 10.1371/journal.pone.0325829 Journal: PloS one Publication Date: 2025-6-17 Authors: Slifirski H, Raykateeraroj N, Armellini A, Hazard R, Zalcman J, et al. Key Points * Approximately 1 in 10 liver transplant patients require ultra-massive fluid transfusion (>20 liters) * Each additional PRBC unit was

Radiology

Deep learning detects retropharyngeal edema on MRI in patients with acute neck infections

PMCID: PMC12179047 PMID: 40536731 DOI: 10.1186/s41747-025-00599-6 Journal: European radiology experimental Publication Date: 2025-6-19 Authors: Rainio O, Huhtanen H, Vierula JP, Nurminen J, Heikkinen J, et al. Key Points * Deep learning algorithm achieved 87.4% accuracy in detecting retropharyngeal edema at the patient level * AUROC values of 94.8%

Infectious_Disease

Infection Spread and Outbreaks Support with Spatial-Temporal Visualization Tool for Hospitals

PMCID: PMC12176923 PMID: 40531282 DOI: 10.1007/s10916-025-02219-7 Journal: Journal of medical systems Publication Date: 2025-6-18 Authors: Kim D, Canovas-Segura B, Campos M, Aleman Belando S, Juarez JM Key Points * Interactive visualization provides a novel method for tracking hospital-acquired infections across spatial and temporal dimensions * User evaluation showed 91.43%

Pulmonology

Diagnostic Use of CCR3, CD63, CD203c and FcεRIα on Blood Leukocytes of Allergic Asthma and Combined Allergic Rhinitis and Asthma Syndrome

PMCID: PMC12176697 PMID: 40534099 DOI: 10.1111/jcmm.70594 Journal: Journal of cellular and molecular medicine Publication Date: 2025-6-18 Authors: Wang J, Zhan M, Gu F, Zhang H, Xie H, et al. Key Points * CCR3+ cell numbers and marker expressions are significantly altered in allergic asthma and allergic rhinitis patients

Immunology

Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis, and inflammation

PMCID: PMC12177736 PMID: 40533345 DOI: 10.26508/lsa.202503264 Journal: Life science alliance Publication Date: 2025-6-18 Authors: Huang S, Patkar OL, Schulze S, Carter-Cusack D, Millard S, et al. Key Points * IL34 deficiency leads to selective microglial depletion in grey matter brain regions * Heterozygous Il34+/- rats demonstrate partial loss

Psychiatry

Transcranial Electrical Stimulation in Treatment of Depression: A Systematic Review and Meta-Analysis

PMCID: PMC12177679 PMID: 40531534 DOI: 10.1001/jamanetworkopen.2025.16459 Journal: JAMA network open Publication Date: 2025-6-18 Authors: Ren C, Pagali SR, Wang Z, Kung S, Boyapati RB, et al. Key Points * tDCS combined with medication showed significant improvement in depression with comorbid conditions * tACS demonstrated improved depressive symptoms in

Infectious_Disease

Vaccine fatigue and influenza vaccination trends across Pre-, Peri-, and Post-COVID-19 periods in the United States using epic’s cosmos database

PMCID: PMC12173228 PMID: 40526617 DOI: 10.1371/journal.pone.0326098 Journal: PloS one Publication Date: 2025-6-17 Authors: Nofzinger TB, Huang TT, Lingat CE, Amonkar GM, Edwards EE, et al. Key Points * Overall influenza vaccination rates decreased by 6.41 percentage points post-COVID-19 * Youngest age groups (5-18 and 19-26 years) experienced