Ethan Littlefield - CurrentMed (Page 26)

Gastroenterology

Importance of the diameter of the mechanical suture in rectal surgery in relation to benign anastomotic stenosis. Cross-sectional observational study

PMCID: PMC12176904 PMID: 40533680 DOI: 10.1007/s10151-025-03157-9 Journal: Techniques in coloproctology Publication Date: 2025-6-18 Authors: Llorach-Perucho N, Cayetano-Paniagua L, Serra-Aracil X Key Points * Postoperative rectal anastomotic stenosis rates range from 2-30%, with surgeons recognizing current rates as clinically significant * 86.1% survey response rate, with 94.3% of surgeons

Infectious_Disease

Animal movement estimation and network-based epidemic modeling: Illustration for the swine industry in Iowa (US)

PMCID: PMC12176235 PMID: 40531924 DOI: 10.1371/journal.pone.0326234 Journal: PloS one Publication Date: 2025-6-18 Authors: Yang Q, Martínez-López B, Moon SA, Gomez-Vazquez JP, Scoglio C Key Points * Synthetic network modeling reveals heterogeneous disease transmission risks across different farm types * Targeted infections at high out-degree farms could potentially cause

Pathology

Inflammatory cells and remodeling in bronchial biopsies from COPD patients and controls

PMCID: PMC12173230 PMID: 40526700 DOI: 10.1371/journal.pone.0326267 Journal: PloS one Publication Date: 2025-6-17 Authors: Eagan TM, Nielsen R, Haaland I, Husebø GR, Lehmann S, et al. Key Points * COPD patients exhibit increased macrophage and eosinophil populations in bronchial submucosa * GOLD stages I/II demonstrated higher eosinophil counts

Surgery

A prospective randomized clinical trial to evaluate wound healing, cosmetic and functional results as well as postoperative adverse events comparing two types of dressing technique after hypospadias repair

PMCID: PMC12177010 PMID: 40533580 DOI: 10.1007/s00383-025-06063-1 Journal: Pediatric surgery international Publication Date: 2025-6-18 Authors: Lawo K, Feller D, Klein BS, Holland-Cunz SG, Frech-Dörfler M Key Points * No significant difference was observed between film and silver pad dressing techniques in wound healing or cosmetic outcomes * Wound dehiscence rate was

Neurology

Longitudinal assessment of cognitive function in testicular cancer patients prior to orchiectomy and 9 months later and associations with tumor markers

PMCID: PMC12174274 PMID: 40526183 DOI: 10.1007/s00520-025-09637-w Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer Publication Date: 2025-6-17 Authors: Højris NF, Frederiksen Y, Agerbæk M, Nielsen SH, Holt M, et al. Key Points * Low prevalence of cognitive impairment (10.3% pre-surgery,

Cardiology

The role of transient receptor potential melastatin channels in compressive force‐induced contraction of primary cardiac pericytes

PMCID: PMC12172562 PMID: 40526043 DOI: 10.14814/phy2.70396 Journal: Physiological reports Publication Date: 2025-6-17 Authors: Methner C, Cilento E, Cao Z, Iliff J, Mishra A, et al. Key Points * Cardiac pericytes possess mechanosensitive TRPM4 and TRPM7 channels that contribute to microvascular dysfunction during acute myocardial infarction * TRPM4 inhibition reduced

Neurology

Brain fluid physiology in ischaemic stroke; more than just oedema

PMCID: PMC12175363 PMID: 40533800 DOI: 10.1186/s12987-025-00671-8 Journal: Fluids and barriers of the CNS Publication Date: 2025-6-18 Authors: Coupland KG, Amell MF, Spratt NJ Key Points * Ischaemic stroke acutely alters CSF and ISF movement, contributing to secondary brain injury * Disrupted fluid dynamics may compromise waste clearance and increase intracranial

Oncology

Oral Soft Tissue and Jawbone Sarcomas: A Retrospective Clinicopathologic Analysis of 128 Cases from Two Institutions and Comprehensive Literature Review

PMCID: PMC12174025 PMID: 40526340 DOI: 10.1007/s12105-025-01811-0 Journal: Head and neck pathology Publication Date: 2025-6-17 Authors: Argyris PP, Dennis GR, Gopalakrishnan R, Koutlas IG, McNamara KK, et al. Key Points * Osteosarcoma and Kaposi sarcoma collectively represent two-thirds of oral soft tissue and jawbone sarcomas * Male-to-female ratio of 1.5:

Neurology

Risk of ischemic stroke associated with anti-rheumatic agents in patients with rheumatoid arthritis: A nationwide population-based case-control study

PMCID: PMC12173416 PMID: 40526615 DOI: 10.1371/journal.pone.0326311 Journal: PloS one Publication Date: 2025-6-17 Authors: Ahn SM, Kim S, Kim YJ, Hong S, Lee CK, et al. Key Points * Sulfasalazine and hydroxychloroquine were associated with reduced stroke risk in RA patients * Glucocorticoids showed a 71% increased stroke risk

Pharmacology

Treatment with gemcitabine/cisplatin and durvalumab for advanced biliary tract cancer – real-world data from a multicenter German patient population

PMCID: PMC12176970 PMID: 40533571 DOI: 10.1007/s00432-025-06239-1 Journal: Journal of cancer research and clinical oncology Publication Date: 2025-6-18 Authors: Gerhardt F, Müller C, Venerito M, Chater J, Mohr R, et al. Key Points * First real-world validation of ICI-based therapy for advanced biliary tract cancers using gemcitabine/cisplatin and durvalumab

Psychiatry

Longitudinal Suicide Risk in Children and Adolescents With Attention Deficit and Hyperactivity Disorder: A Systematic Review and Meta‐Analysis

PMCID: PMC12177204 PMID: 40534226 DOI: 10.1002/brb3.70618 Journal: Brain and behavior Publication Date: 2025-6-18 Authors: Garas P, Takacs ZK, Balázs J Key Points * Individuals with ADHD have a 3-4 times higher risk of suicidal behaviors compared to non-ADHD populations * Suicide risk varies significantly across ADHD subtypes, with combined

Pharmacology

An Acrolein-Based Drug Delivery System Enables Tumor-Specific Sphingosine-1-Phosphate Targeting in Breast Cancer without Lymphocytopenia

PMCID: PMC12174973 PMID: 40528704 DOI: 10.1158/2767-9764.CRC-25-0023 Journal: Cancer research communications Publication Date: 2025-6 Authors: Nagahashi M, Komatsu M, Urano S, Kuroiwa M, Takahashi Y, et al. Key Points * Pro-FTY selectively targets and inhibits breast cancer cells, including multidrug-resistant variants, using an acrolein-responsive drug delivery system * Demonstrated 100%