Ethan Littlefield

Oncology

Outcomes Following Transoral Laser Microsurgery for T1b and T2a Glottic Squamous Cell Carcinoma With and Without Anterior Commissure Involvement: A Retrospective Chart Review

PMCID: PMC12177246 PMID: 40530452 DOI: 10.1177/19160216251348424 Journal: Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale Publication Date: 2025-6-18 Authors: Patel D, Taylor V, MacKay C, den Besten C, Rigby MH, et al. Key Points * TLM demonstrates comparable oncological outcomes

By Ethan Littlefield

Oncology

The efficacy and therapy management of nab-paclitaxel in the real-world setting for patients with advanced breast cancer – the SERAPHINA study

PMCID: PMC12178961 PMID: 40536732 DOI: 10.1007/s00432-025-06246-2 Journal: Journal of cancer research and clinical oncology Publication Date: 2025-6-19 Authors: Schneeweiss A, Fasching PA, Thill M, van Mackelenbergh M, Marme F, et al. Key Points * Nab-paclitaxel demonstrated consistent efficacy across multiple treatment lines in advanced breast cancer * Median progression-free survival

By Ethan Littlefield

Oncology

Myeloid‐Derived LGALS9‐P4HB Immune Interaction Promotes Metastasis in Gastric Cancer Through Enhanced Cell Proliferation and Lipid Metabolism

PMCID: PMC12176694 PMID: 40534096 DOI: 10.1111/jcmm.70661 Journal: Journal of cellular and molecular medicine Publication Date: 2025-6-18 Authors: Zhu X, Zhang Y, Yu A, Xiao X Key Points * Myeloid cell-derived LGALS9 and epithelial cell P4HB interaction is a previously uncharacterized mechanism driving gastric cancer metastasis * Pharmacological P4HB inhibitors

By Ethan Littlefield

Cardiology

Atrial dysfunction: a contrast-free marker for HFpEF in obese diabetics—insights from comprehensive CMR and serum biomarker analyses

PMCID: PMC12175437 PMID: 40533773 DOI: 10.1186/s12933-025-02808-3 Journal: Cardiovascular diabetology Publication Date: 2025-6-18 Authors: Beyer RE, Müller ML, Doeblin P, Werhahn SM, Chiribiri A, et al. Key Points * Left atrial function metrics provide the most reliable CMR-based differentiation of HFpEF from similar clinical conditions * LA maximum volume showed the

By Ethan Littlefield

Pharmacology

Differing Genetics of Saline and Cocaine Self‐Administration in the Hybrid Mouse Diversity Panel

PMCID: PMC12173464 PMID: 40527326 DOI: 10.1111/gbb.70029 Journal: Genes, brain, and behavior Publication Date: 2025-6-17 Authors: Khan AH, Bagley JR, LaPierre N, Gonzalez‐Figueroa C, Spencer TC, et al. Key Points * 145 unique genetic loci were identified for saline self-administration, indicating complex genetic regulation of behavioral endpoints * Only

By Ethan Littlefield

Pharmacology

Comparative effectiveness of interventions to facilitate deprescription of benzodiazepines and other sedative hypnotics: systematic review and meta-analysis

PMCID: PMC12171951 PMID: 40527546 DOI: 10.1136/bmj-2024-081336 Journal: BMJ (Clinical research ed.) Publication Date: 2025 Authors: Zeraatkar D, Nagraj SK, Ling M, Jassal T, Kirsh S, et al. Key Points * Patient education and pharmacist-led interventions showed the most promise in facilitating BSH discontinuation * Low-certainty evidence suggests 144 more patients

By Ethan Littlefield

Immunology

Monoclonal humanized monovalent antibody blocking therapy for anti-NMDA receptor encephalitis

PMCID: PMC12174348 PMID: 40527893 DOI: 10.1038/s41467-025-60628-1 Journal: Nature communications Publication Date: 2025-6-17 Authors: Kanno A, Kito T, Maeda M, Yamaki S, Amano Y, et al. Key Points * First monovalent antibody designed to specifically block pathogenic NMDAR autoantibodies without receptor dysfunction * Demonstrated 74% reversal of NMDAR internalization at 2.

By Ethan Littlefield

Oncology

Repurposing MDM2 inhibitor RG7388 for TP53-mutant NSCLC: a p53-independent pyroptotic mechanism via ROS/p-p38/NOXA/caspase-3/GSDME axis

PMCID: PMC12170848 PMID: 40523886 DOI: 10.1038/s41419-025-07770-2 Journal: Cell death & disease Publication Date: 2025-6-17 Authors: Tang G, Cao X, Chen J, Hui F, Xu N, et al. Key Points * RG7388 exhibits potent anti-tumor effects in TP53-mutant NSCLC through a p53-independent mechanism * Significant dose-dependent reduction in cell viability across

By Ethan Littlefield

Obstetrics_Gynecology

A comparative systematic review and meta-analysis of uterine artery resistance in pregnant women with and without previous history of cesarean section

PMCID: PMC12176234 PMID: 40531956 DOI: 10.1371/journal.pone.0325352 Journal: PloS one Publication Date: 2025-6-18 Authors: Mohazzab A, Mohammadzadeh A, Nikfar B, Masoumi S, Shoraka E, et al. Key Points * A history of cesarean section may be associated with slightly increased uterine artery resistance * Small but statistically significant effect:

By Ethan Littlefield

Endocrinology

Rice bran extract attenuates cognitive impairment by enhancing pancreatic β-cell insulin secretion in STZ-induced diabetic rats targeting the PPARγ/PDX1 pathway

PMCID: PMC12178994 PMID: 40536613 DOI: 10.1007/s11011-025-01639-1 Journal: Metabolic brain disease Publication Date: 2025-6-19 Authors: Youssef MM, El-Yamany MF, Abdel-Kader RM, Heikal OA Key Points * RBE treatment significantly restored pancreatic insulin levels and improved β-cell function in diabetic rats * Pancreatic GLUT2 levels increased by 126.495% in RBE-treated diabetic

By Ethan Littlefield
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