Ethan Littlefield - CurrentMed (Page 24)

Surgery

A fast and easy-to-perform noninvasive Muller’s muscle sublimation technique using plasma technology for treatment of mild-to-moderate ptosis: a case report

PMCID: PMC12175309 PMID: 40528246 DOI: 10.1186/s13256-025-05330-y Journal: Journal of medical case reports Publication Date: 2025-6-17 Authors: Raffati N Key Points * Plasma scalpel technology offers a promising minimally invasive alternative for ptosis correction * Mean MRD1 improvement of 2.08 mm across all patients, indicating effective lid elevation * Potential to

Pharmacology

Multimodal CustOmics: A unified and interpretable multi-task deep learning framework for multimodal integrative data analysis in oncology

PMCID: PMC12173418 PMID: 40526743 DOI: 10.1371/journal.pcbi.1013012 Journal: PLoS computational biology Publication Date: 2025-6-17 Authors: Benkirane H, Vakalopoulou M, Planchard D, Adam J, Olaussen K, et al. Key Points * Multimodal CustOmics achieved superior predictive performance across multiple cancer types, with classification AUC consistently above 98% when integrating

Nephrology

Efficacy of Nrf2 activation in a proteinuric Alport syndrome mouse model

PMCID: PMC12174586 PMID: 40527586 DOI: 10.26508/lsa.202503330 Journal: Life science alliance Publication Date: 2025-6-17 Authors: Kaseda S, Horizono J, Sannomiya Y, Kuwazuru J, Suico MA, et al. Key Points * UD-051, a novel Keap1-Nrf2 protein interaction inhibitor, demonstrated kidney protective effects in Alport syndrome by targeting tubular injury * Combination

Immunology

CAR‐NK, a Splendid Strategy for Cancer, Especially for Gynecologic Tumor

PMCID: PMC12171998 PMID: 40525700 DOI: 10.1002/iid3.70210 Journal: Immunity, inflammation and disease Publication Date: 2025-6-17 Authors: Cao Y, Wang L, Wang L Key Points * CAR-NK cells provide a safer, more adaptable immunotherapy alternative to CAR-T cells * Potential for "off-the-shelf" manufacturing reduces personalization complexity and treatment time

Pharmacology

Perceptions of chemoprevention among individuals at high risk of oral cancer: qualitative study within the UK-based SAVER trial

PMCID: PMC12182162 PMID: 40527552 DOI: 10.1136/bmjopen-2025-101326 Journal: BMJ open Publication Date: 2025 Authors: Sherratt F, McCarthy C, Jiménez-Tomàs A, Perry J, Kuruvilla R, et al. Key Points * Individuals with oral epithelial dysplasia are generally open to chemoprevention research, motivated by potential cancer risk reduction * Most participants (11/20)

Infectious_Disease

Clade II Mpox Infections Among Cruise Ship Passengers and Crew Members — United States, 2024

PMCID: PMC12176104 PMID: 40531694 DOI: 10.15585/mmwr.mm7422a1 Journal: MMWR. Morbidity and mortality weekly report Publication Date: 2025-6-19 Authors: Ortiz N, Rodriguez LR, McPherson M, Pringle K, Rao AK, et al. Key Points * Eight mpox cases identified across four cruise ship voyages, with transmission primarily among crew members and

Pulmonology

Risk Factors and Long‐Term Prognosis for Coinfection of Nontuberculous Mycobacterial Pulmonary Disease and Chronic Pulmonary Aspergillosis: A Multicentre Observational Study in Japan

PMCID: PMC12178108 PMID: 40536274 DOI: 10.1111/myc.70083 Journal: Mycoses Publication Date: 2025-6-19 Authors: Tanaka Y, Ide S, Takazono T, Takeda K, Iwanaga N, et al. Key Points * CPA coinfection occurs in 3.5% of NTM-PD patients, with Aspergillus fumigatus being the most common causative species * Male sex, COPD,

Nephrology

A Study on the Neurological Mechanisms of the Impact of Different Dialysis Methods on Brain Structure and Functional Network Dynamic Reorganization in Patients With End‐Stage Renal Disease Undergoing Dialysis

PMCID: PMC12177206 PMID: 40534242 DOI: 10.1002/brb3.70623 Journal: Brain and behavior Publication Date: 2025-6-18 Authors: Han H, Chen H, Zhang Y, Wei J Key Points * Peritoneal dialysis demonstrated superior cognitive preservation compared to hemodialysis * MMSE scores improved from 16.01 to 19.56 in the peritoneal dialysis group

Gastroenterology

Establishing high risk factors for recurrence in stage I/II colorectal cancer: a metropolitan perspective

PMCID: PMC12175440 PMID: 40533762 DOI: 10.1186/s12957-025-03823-0 Journal: World journal of surgical oncology Publication Date: 2025-6-18 Authors: Wood PC, Zammit AP, Ferris B, Simpson FH, Burge M, et al. Key Points * Overall recurrence rate of 13.3% in early-stage CRC, with stage II patients at higher risk * Venous invasion,

Oncology

Impact of multikinase inhibitors in reshaping the treatment of advanced gastroenteropancreatic neuroendocrine tumors

PMCID: PMC12177888 PMID: 40392078 DOI: 10.1530/ERC-25-0052 Journal: Endocrine-related cancer Publication Date: 2025-6-18 Authors: Siebenhüner AR, Refardt J, Nicolas GP, Kaderli R, Walter MA, et al. Key Points * MKIs represent a significant advancement in GEP-NET treatment, offering improved progression-free survival across multiple tumor subtypes * Median PFS improvements range from

Psychiatry

Experiential Avoidance as a Transdiagnostic Mediator in the Relationship Between Intolerance of Uncertainty, Maladaptive Perfectionism, and Psychiatric Symptoms: Structural and Causal Mediation Analyses in a Clinical Sample

PMCID: PMC12178104 PMID: 40536179 DOI: 10.1002/cpp.70102 Journal: Clinical psychology & psychotherapy Publication Date: 2025-6-19 Authors: Gerdan G, Salcioglu E Key Points * Experiential avoidance fully mediates the relationship between intolerance of uncertainty, maladaptive perfectionism, and psychiatric symptoms * EA explained 1.254 standard deviations in the relationship between intolerance

Surgery

Understanding and acceptance of open, laparoscopic, and robotic surgery among nursing students: implications for educational curricula based on a mixed-methods study

PMCID: PMC12176940 PMID: 40533608 DOI: 10.1007/s11701-025-02373-7 Journal: Journal of robotic surgery Publication Date: 2025-6-18 Authors: Özkan E, Çankaya A, Özsoy H Key Points * Nursing students showed varying levels of surgical technology knowledge, with mean knowledge scores of 5.26 for open surgery, 2.49 for laparoscopic surgery, and