Ethan Littlefield - CurrentMed (Page 20)

Oncology

EGFRvIII-positive glioblastoma contributes to immune escape and malignant progression via the c-Fos-MDK-LRP1 axis

PMCID: PMC12174314 PMID: 40527884 DOI: 10.1038/s41419-025-07771-1 Journal: Cell death & disease Publication Date: 2025-6-17 Authors: Yuan F, Wang Y, Yuan L, Tang T, Ye L, et al. Key Points * EGFRvIII mutation is associated with higher WHO grade 4 gliomas (93.3% vs. 53.6%, p=0.044) * M2

Gastroenterology

Neurological Manifestations of HEV Infection: A Rare Phenomenon or an Underrecognized Reality?

PMCID: PMC12177195 PMID: 40534221 DOI: 10.1002/brb3.70585 Journal: Brain and behavior Publication Date: 2025-6-18 Authors: Iza M, Ramos D, Llauradó A, Restrepo‐Vera JL, Pallero M, et al. Key Points * HEV can cause diverse neurological manifestations, including neuralgic amyotrophy and meningoradiculitis, in immunocompetent patients * Initial HEV viral loads

Endocrinology

Stable heritability of type 1 diabetes in a Swedish Nationwide Cohort Study

PMCID: PMC12174315 PMID: 40527903 DOI: 10.1038/s41467-025-60813-2 Journal: Nature communications Publication Date: 2025-6-17 Authors: Wei Y, Andersson T, Liu S, Feychting M, Kuja-Halkola R, et al. Key Points * T1D incidence nearly doubled between 1982-2000, with a hazard ratio of 1.85 (95% CI: 1.65, 2.08) for children

Obstetrics_Gynecology

Divergence in the sow vaginal microbiota is associated with fertility

PMCID: PMC12177788 PMID: 40470844 DOI: 10.1530/REP-25-0044 Journal: Reproduction (Cambridge, England) Publication Date: 2025-6-18 Authors: Fletcher L, Zhan X, Song Y, Li J Key Points * Vaginal microbiota composition shows promise as a novel biomarker for predicting sow fertility * Machine learning model achieved 93.3% accuracy in classifying reproductive performance

Cardiology

Emulating the EPIC trial using VetCompass primary-care data: causal effects of pimobendan in UK dogs with grade IV/VI heart murmurs

PMCID: PMC12176212 PMID: 40531835 DOI: 10.1371/journal.pone.0325695 Journal: PloS one Publication Date: 2025-6-18 Authors: Pegram C, Diaz-Ordaz K, Brodbelt DC, Chang YM, Boswood A, et al. Key Points * Pimobendan prescription within 6 months of grade IV heart murmur diagnosis reduced 5-year CHF cumulative incidence by 22.2%

Psychiatry

A one-arm pilot trial of a telehealth CBT-based group intervention targeting transdiagnostic risk for emotional distress

PMCID: PMC12176177 PMID: 40531853 DOI: 10.1371/journal.pone.0303131 Journal: PloS one Publication Date: 2025-6-18 Authors: Flynt S, Cho GY, Koscinski B, Accorso C, Knapp A, et al. Key Points * Telehealth-delivered modular CBT intervention shows potential for addressing transdiagnostic mental health risk factors * 85% participant retention rate and high

Oncology

N6-methyladenosine-modified GPX2 impacts cancer cell stemness and TKI resistance through regulating of redox metabolism

PMCID: PMC12177039 PMID: 40533443 DOI: 10.1038/s41419-025-07764-0 Journal: Cell death & disease Publication Date: 2025-6-18 Authors: Yang X, Yu L, Shao M, Yang H, Qi K, et al. Key Points * GPX2 serves as a critical mediator of EGFR-TKI resistance in NSCLC by modulating cellular redox balance * Knockdown of GPX2

Pharmacology

[18F]FET PET-Guided management of pseudoprogression in glioblastoma (FET POPPING): the study protocol for a diagnostic randomized clinical trial

PMCID: PMC12175455 PMID: 40528226 DOI: 10.1186/s13063-025-08921-8 Journal: Trials Publication Date: 2025-6-17 Authors: Ruijters VJ, Snijders TJ, van der Pol JA, van de Giessen EM, Niers JM, et al. Key Points * First comprehensive randomized trial investigating FET PET's utility in differentiating pseudoprogression from true tumor progression in

Neurology

The neurobiological foundation of effective repetitive transcranial magnetic brain stimulation in Alzheimer's disease

PMCID: PMC12175030 PMID: 40530618 DOI: 10.1002/alz.70337 Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association Publication Date: 2025-6-18 Authors: Antonioni A, Martorana A, Santarnecchi E, Hampel H, Koch G Key Points * rTMS demonstrates comprehensive neurobiological modulation in AD, targeting synaptic, molecular, and

Endocrinology

Placental inflammation is increased in gestational diabetes mellitus: The role of inflammasome NLRP-3 and chemokine scavenger decoy receptor D6

PMCID: PMC12173348 PMID: 40526637 DOI: 10.1371/journal.pone.0326087 Journal: PloS one Publication Date: 2025-6-17 Authors: Onori M, Beneduce G, Colella F, Lucchetti D, Policola C, et al. Key Points * GDM is characterized by elevated pro-inflammatory cytokines and increased NLRP-3 inflammasome expression * Statistically significant differences observed: CCL-2 (p <

Neurology

Influences of Gait Training with Knee–Ankle–Foot Orthosis on Gait Ability and Independence in Severe Hemiplegia and Pusher Behavior with Unilateral Spatial Neglect Following Stroke: A Retrospective Historical Controlled Study

PMCID: PMC12177197 PMID: 40534213 DOI: 10.1002/brb3.70535 Journal: Brain and behavior Publication Date: 2025-6-18 Authors: Sawa K, Tamura M, Arai S Key Points * Long-term KAFO intervention showed differential improvements across stroke patient subgroups * Days since stroke onset and sensorimotor variability were critical predictors of gait independence (p <

Psychiatry

Understanding Youth Online Experiences and Mental Health: Development and Validation of the Digital Activity and Feelings Inventory (DAFI)

PMCID: PMC12173090 PMID: 40526710 DOI: 10.1002/mpr.70028 Journal: International journal of methods in psychiatric research Publication Date: 2025-6-17 Authors: Katarzyna K, Jake B, Aja M, Mariya S, Iqra A, et al. Key Points * Social comparison and negative self-reactions were stronger predictors of mental health outcomes than total screen