Ethan Littlefield - CurrentMed (Page 2)

Neurology

Down syndrome with Alzheimer's disease brains have increased iron and associated lipid peroxidation consistent with ferroptosis

PMCID: PMC12177674 PMID: 40536124 DOI: 10.1002/alz.70322 Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association Publication Date: 2025-6-19 Authors: Thorwald MA, Godoy‐Lugo JA, Kerstiens E, Garcia G, Kim M, et al. Key Points * DSAD demonstrates more pronounced iron-mediated oxidative stress compared

Immunology

Kruppel-like factor 9 may regulate the inflammatory injury of chondrocytes by affecting NF-κB signaling

PMCID: PMC12175337 PMID: 40533763 DOI: 10.1186/s13018-025-05974-y Journal: Journal of orthopaedic surgery and research Publication Date: 2025-6-18 Authors: Gu H, Han X, Ding Y, Deng J Key Points * KLF9 is a critical molecular factor that can potentially mitigate inflammatory responses in osteoarthritis * KLF9 overexpression reduced pro-inflammatory cytokines by up

Surgery

Long-term outcomes after a trimalleolar fracture involving the posterior malleolar fragment: an 11-year follow-up

PMCID: PMC12176937 PMID: 40531350 DOI: 10.1007/s00402-025-05959-w Journal: Archives of orthopaedic and trauma surgery Publication Date: 2025-6-18 Authors: Chidda A, Soares S, Tannast M, Schwab J, Seidel A Key Points * PMF fixation did not improve long-term clinical outcomes in trimalleolar ankle fractures * Fixated group had significantly larger PMF sizes

Oncology

Targeting Drp1 inhibits ESCC progression via the ROS-PGC1-α-Nrf1/2 pathway

PMCID: PMC12175380 PMID: 40528181 DOI: 10.1186/s12967-025-06697-8 Journal: Journal of translational medicine Publication Date: 2025-6-17 Authors: Jiang Z, Yang Y, Zhou J, Li X, Meng Q, et al. Key Points * Drp1 overexpression is a significant driver of ESCC growth and metastasis * High Drp1 expression correlates with poor patient prognosis

Infectious_Disease

Pandemic-related experiences of older adults and people with disabilities

PMCID: PMC12173368 PMID: 40526622 DOI: 10.1371/journal.pone.0325306 Journal: PloS one Publication Date: 2025-6-17 Authors: Mortenson WB, Esfandiari E, Mohammadi S, Sakakibara B, Schmidt J, et al. Key Points * COVID-19 restrictions dramatically altered capabilities and functionings for people with disabilities, creating unique challenges in daily life * 71 participants

Oncology

PDGF‐D Promotes Epithelial–Mesenchymal Transition of Glioma Cells Through the NF‐κB/NOTCH1 Pathway

PMCID: PMC12175480 PMID: 40530904 DOI: 10.1002/cam4.71002 Journal: Cancer medicine Publication Date: 2025-6-18 Authors: Li Y, Zhao Y, Shi M, Ma X, Jia M, et al. Key Points * PDGF-D expression positively correlates with glioma malignancy and WHO tumor grade * Knockdown of PDGF-D significantly reduced colony formation by p

Pulmonology

N95 masks increase brain blood velocity and parasympathetic outflow, yet worsen orthostatic symptoms in a healthy cohort

PMCID: PMC12177107 PMID: 40534183 DOI: 10.14814/phy2.70402 Journal: Physiological reports Publication Date: 2025-6-18 Authors: Pereira TJ, Edgell H Key Points * Mask wearing increased systolic cerebral blood flow but paradoxically worsened orthostatic intolerance symptoms * Total Vanderbilt Orthostatic Symptom Score increased from 12 to 20 during masked trials (p=0.

Oncology

MicroRNA Let‐7b‐5p Targets IGF1R to Inhibit the Progression of Hepatocellular Carcinoma Through the AKT/mTOR Pathway

PMCID: PMC12175197 PMID: 40530890 DOI: 10.1002/cam4.71000 Journal: Cancer medicine Publication Date: 2025-6-18 Authors: Liang J, Li A, Chen J, Cao N, Zhu T, et al. Key Points * Let-7b-5p is significantly downregulated in HCC, associated with reduced patient survival (p = 0.04805) * Overexpression of Let-7b-5p decreased HCC cell

Oncology

Modulating autophagy in KRAS mutant colorectal cancer using combination of oncolytic reovirus and carbamazepine

PMCID: PMC12173229 PMID: 40526688 DOI: 10.1371/journal.pone.0326029 Journal: PloS one Publication Date: 2025-6-17 Authors: Shaykevich A, Chae D, Silverman I, Goel S, Maitra R Key Points * Carbamazepine and oncolytic reovirus demonstrate synergistic effects in inducing autophagy in KRAS-mutated colorectal cancer cells * Dual treatment significantly increased autophagy-related protein

Surgery

A narrative review and scoring proposal for secondary lumbar instability after lumbar decompression surgery

PMCID: PMC12177027 PMID: 40531241 DOI: 10.1007/s00701-025-06590-9 Journal: Acta neurochirurgica Publication Date: 2025-6-18 Authors: Abramovic A, Lener S, Hartmann S, Thomé C Key Points * A comprehensive 14-point scoring system was developed to predict secondary lumbar instability risk after decompressive surgery * Key risk factors include disc height > 6.5

Oncology

Hypoxia‐induced PGK1 expression promotes esophageal squamous cell carcinoma progression via stimulating MYH9‐mediated GSK3β/β‐catenin signalling

PMCID: PMC12177104 PMID: 40534132 DOI: 10.1002/ctm2.70376 Journal: Clinical and translational medicine Publication Date: 2025-6-18 Authors: Xu J, Wu L, Chen T, Liu Y, Zhang Y, et al. Key Points * Elevated PGK1 levels correlate with poor survival and advanced tumor stages in ESCC patients * PGK1 promotes tumor progression

Psychiatry

Sexual dysfunction and other prolactin-related side effects of antipsychotic drugs in schizophrenia: Protocol for a systematic review with single-arm, pairwise, and network meta-analyses of randomized controlled trials and non-randomized studies

PMCID: PMC12138325 PMID: 40474917 DOI: 10.12688/f1000research.154742.1 Journal: F1000Research Publication Date: 2025-6-19 Authors: Schneider-Thoma J, Dong S, Kim DD, Efthimiou O, Siafis S, et al. Key Points * Sexual dysfunctions are prevalent in schizophrenia patients, potentially impacting treatment adherence and quality of life * The study will comprehensively analyze