Ethan Littlefield - CurrentMed (Page 14)

Anesthesiology

Efficacy and safety of ciprofol for sedation/anesthesia in patients undergoing hysteroscopy: a prospective, randomized, non-inferiority trial

PMCID: PMC12180349 PMID: 40530830 DOI: 10.1080/07853890.2025.2517820 Journal: Annals of medicine Publication Date: 2025-6-18 Authors: Cheng S, Wu H, Liu Z, Liu D, Cao M, et al. Key Points * Ciprofol demonstrated non-inferior anesthetic efficacy compared to propofol for hysteroscopy * Injection pain was dramatically reduced in ciprofol group

Oncology

Bladder cancer variants share aggressive features including a CA125+ cell state and targetable TM4SF1 expression

PMCID: PMC12174346 PMID: 40527915 DOI: 10.1038/s41467-025-59888-8 Journal: Nature communications Publication Date: 2025-6-17 Authors: Yang H, Song H, Yip E, Gilpatrick T, Chang K, et al. Key Points * HV bladder cancers harbor a unique tumor cell state with distinct molecular characteristics, primarily expressing CA125, MUC4, and KRT24 * CA125+ cells

Gastroenterology

Single-cell dissection of prognostic architecture and immunotherap response in Helicobacter pylori infection-associated gastric cancer

PMCID: PMC12173458 PMID: 40525824 DOI: 10.7554/eLife.99337 Journal: eLife Publication Date: 2025-6-17 Authors: Zhang X, Zhang G, Sang S, Fei Y, Cao X, et al. Key Points * H. pylori infection fundamentally reshapes gastric cancer's tumor microenvironment, increasing inflammatory and angiogenic cellular components * iCAF abundance and angiogenic

Endocrinology

Effects of family history and sex on diabetes-related outcome in type 2 diabetes – Analysis from the tyrolean diabetes registry

PMCID: PMC12176189 PMID: 40531860 DOI: 10.1371/journal.pone.0324696 Journal: PloS one Publication Date: 2025-6-18 Authors: Plattner C, Pfeifer B, Sourij H, Vill D, Wiedl M, et al. Key Points * Family history of diabetes is associated with earlier T2D diagnosis (mean age 51.89 vs. 56.59 years) * Increased

Anesthesiology

Sedation and analgesia in post-cardiac arrest care: a post hoc analysis of the TTM2 trial

PMCID: PMC12175406 PMID: 40528173 DOI: 10.1186/s13054-025-05461-0 Journal: Critical care (London, England) Publication Date: 2025-6-17 Authors: Ceric A, Dankiewicz J, Cronberg T, Düring J, Moseby-Knappe M, et al. Key Points * Higher propofol doses (Q3: 100.7-153.6 mg/kg) significantly improved functional outcomes and survival * Fentanyl and remifentanil use

Pharmacology

Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acids: advances and challenges

PMCID: PMC12178025 PMID: 40533746 DOI: 10.1186/s12951-025-03528-2 Journal: Journal of nanobiotechnology Publication Date: 2025-6-18 Authors: Sanadgol N, Abedi M, Hashemzaei M, Kamran Z, Khalseh R, et al. Key Points * Exosomes provide a safer, more controllable alternative to cell-based therapies, eliminating risks like teratoma formation * Emerging strategies like cell-penetrating peptide

Pathology

Targeting Oncofoetal Chondroitin Sulphate Allows Identification of Tumour‐Derived Extracellular Vesicles

PMCID: PMC12173530 PMID: 40527727 DOI: 10.1002/jev2.70106 Journal: Journal of extracellular vesicles Publication Date: 2025-6-17 Authors: Enciso‐Martinez A, Løppke C, Koene JJ, Ebbelaar J, van der Geest M, et al. Key Points * First comprehensive method for specifically identifying tumor-derived extracellular vesicles using oncofoetal chondroitin sulphate * Demonstrated ofCS

Pharmacology

Multi‐Target Drug Design in Alzheimer's Disease Treatment: Emerging Technologies, Advantages, Challenges, and Limitations

PMCID: PMC12175645 PMID: 40531439 DOI: 10.1002/prp2.70131 Journal: Pharmacology research & perspectives Publication Date: 2025-6-18 Authors: Hossain MS, Hussain MH Key Points * Multi-target drug design offers a more holistic approach to treating Alzheimer's disease by simultaneously addressing multiple pathological mechanisms * Emerging technologies like AI and nanomedicine

Pulmonology

Assessment of ventilation heterogeneity in severe asthma using phase‐resolved functional lung magnetic resonance imaging

PMCID: PMC12177108 PMID: 40534189 DOI: 10.14814/phy2.70423 Journal: Physiological reports Publication Date: 2025-6-18 Authors: Foo CT, Langton D, Donovan GM, Thompson BR, Noble PB, et al. Key Points * PREFUL MRI revealed significantly higher ventilation defect percentages in severe asthma patients (19.9% vs. 1.9% in healthy volunteers)

Surgery

Robotic Submesocolic Left Adrenalectomy: The Evolution of Delbet Approach

PMCID: PMC12172399 PMID: 40525778 DOI: 10.1002/rcs.70080 Journal: The international journal of medical robotics + computer assisted surgery : MRCAS Publication Date: 2025-6-17 Authors: Ortenzi M, Santini A, Balla A, Corallino D, Lezoche G, et al. Key Points * Robotic submesocolic approach demonstrates safety and feasibility for left adrenalectomy * Operative time

Public_Health

Experiences of postnatal contraceptive care during the COVID-19 pandemic: a multimethods cross-sectional study

PMCID: PMC12182104 PMID: 40527556 DOI: 10.1136/bmjopen-2024-095608 Journal: BMJ open Publication Date: 2025 Authors: Kelly S, Moffat M, Thompson C, Jackowich R, Möller-Christensen C, et al. Key Points * Women who delivered in 2020 had significantly fewer postnatal healthcare provider contacts compared to 2021-2022 cohorts * Only 42.7% of women

Gastroenterology

Laparoscopic appendectomy as the gold standard: What role remains for open surgery, conversion, and disease severity?: An analysis of 32,000 cases with appendicitis in Germany

PMCID: PMC12178000 PMID: 40533760 DOI: 10.1186/s13017-025-00626-2 Journal: World journal of emergency surgery : WJES Publication Date: 2025-6-18 Authors: Schildberg C, Weber U, König V, Linnartz M, Heisler S, et al. Key Points * Laparoscopic appendectomy became the predominant surgical approach, reaching >95% of procedures annually since 2017 * Conversion to