Ethan Littlefield - CurrentMed (Page 13)

Surgery

Simulation and comparison of objectively graded microsurgery steps by using a microscope and Symani robotic system by young professionals

PMCID: PMC12174173 PMID: 40526352 DOI: 10.1007/s11701-025-02490-3 Journal: Journal of robotic surgery Publication Date: 2025-6-17 Authors: Wieker H, Brandenburg N, Spille D, Wagner J, Weitkamp JT, et al. Key Points * Young medical professionals can effectively operate both microscope and robotic microsurgical systems without prior specialized training * 95% of participants

Pharmacology

The GPR88 Agonist RTI‐122 Reduces Alcohol‐Related Motivation and Consumption

PMCID: PMC12178211 PMID: 40536830 DOI: 10.1111/adb.70058 Journal: Addiction biology Publication Date: 2025-6-19 Authors: Lovelock DF, Liu W, Hamida SB, Cordero VL, Van Voorhies KJ, et al. Key Points * RTI-122 demonstrates a selective, receptor-specific mechanism for reducing alcohol consumption across multiple experimental models * Significant reductions in alcohol intake

Pulmonology

The effect of target transpulmonary driving pressure values on mortality in ARDS patients: A retrospective study based on the MIMIC-IV database

PMCID: PMC12176163 PMID: 40531833 DOI: 10.1371/journal.pone.0326060 Journal: PloS one Publication Date: 2025-6-18 Authors: Liu N, Zhang Q, Wang H, Ding R, Geng X, et al. Key Points * Transpulmonary driving pressure >12.5 cmH2O is associated with increased mortality in ARDS patients * Targeted TPDP management reduced

Public_Health

Use and Perception of Video Consultations Among Swedish Dietitians Before and After COVID‐19 Onset

PMCID: PMC12177270 PMID: 40534156 DOI: 10.1111/jhn.70080 Journal: Journal of human nutrition and dietetics : the official journal of the British Dietetic Association Publication Date: 2025-6-18 Authors: Persson S, Liljegren AE, Olsson C, Rydén P Key Points * Video consultation usage among Swedish Registered Dietitians increased over 300% between 2016

Oncology

A multicenter prospective study to determine the optimal range of lymph node dissection in pancreatic cancer surgery after neoadjuvant chemotherapy (LYMRIN-Trial): Project study by the Japan Pancreas Society and JON 2302-P

PMCID: PMC12173190 PMID: 40526592 DOI: 10.1371/journal.pone.0325667 Journal: PloS one Publication Date: 2025-6-17 Authors: Kimura N, Shirai Y, Itoh A, Hirano K, Shibuya K, et al. Key Points * Comprehensive multicenter study addressing optimal lymph node dissection in PDAC * Evaluating metastasis rates across different pancreatic tumor locations to

Emergency_Medicine

Risk factors associated with unplanned readmissions and frequent out-of-hour emergency department visits after pediatric tracheostomy: a nationwide inpatient database study in Japan

PMCID: PMC12170732 PMID: 40523996 DOI: 10.1007/s00431-025-06242-1 Journal: European journal of pediatrics Publication Date: 2025-6-17 Authors: Ito-Shinjo A, Shinjo D, Nakamura T, Kubota M, Fushimi K Key Points * Pediatric tracheostomy patients under 1 year old have significantly higher risks of readmission and emergency department visits * 43% of patients were

Pharmacology

Case Report WIN-MTB-2023001 WIN International Molecular Tumor Board A 62-year-old male with metastatic colorectal cancer with 5 prior lines of treatment

PMCID: PMC12175699 PMID: 40526090 DOI: 10.18632/oncotarget.28744 Journal: Oncotarget Publication Date: 2025 Authors: Hernando-Calvo A, Kurzrock R, Gonzalez NS, Magidi S, Bresson C, et al. Key Points * Comprehensive molecular profiling revealed multiple actionable genetic alterations in mCRC * Personalized treatment strategies proposed, including targeted therapies matching specific mutations * Repeated

Pharmacology

Liposome Encapsulation Enhances Ripasudil Therapeutic Efficacy Against Proliferative Vitreoretinal Diseases: Implications in Advanced Ocular Treatment

PMCID: PMC12178431 PMID: 40525920 DOI: 10.1167/iovs.66.6.56 Journal: Investigative ophthalmology & visual science Publication Date: 2025-6-17 Authors: Ji R, Ishikawa K, Tan W, Mori K, Tsukamoto R, et al. Key Points * Liposomal encapsulation of ripasudil dramatically improves drug retention and targeted delivery in ocular tissues * Lipo-Ripa

Immunology

Lymphocyte immunophenotype in dogs with immune-mediated hematologic disease

PMCID: PMC12173396 PMID: 40526723 DOI: 10.1371/journal.pone.0326341 Journal: PloS one Publication Date: 2025-6-17 Authors: Blois SL, Cuq BY, Bienzle D Key Points * Dogs with IMHD demonstrated significantly lower proportions of CD4+ and CD8+ lymphocytes compared to healthy controls (p < 0.0001) * T regulatory cells were reduced

Pharmacology

Hitting Two Birds With One Stone: Dual Modulation of Brain Carbonic Anhydrases and Histone Deacetylases Boosts Memory Consolidation

PMCID: PMC12174897 PMID: 40528640 DOI: 10.1002/ardp.70020 Journal: Archiv der Pharmazie Publication Date: 2025-6-18 Authors: Costa A, Bozdag M, Renzi G, Rani B, Passani MB, et al. Key Points * Multi-targeted molecular approach shows promise for cognitive impairment treatment * Compounds 12 and 14 demonstrated memory enhancement at doses 10x

Surgery

Unusual causes of perineal trauma in paediatric patients: lessons learned from a high-volume colorectal clinic in a low-and-middle-income country

PMCID: PMC12176936 PMID: 40533567 DOI: 10.1007/s00383-025-06075-x Journal: Pediatric surgery international Publication Date: 2025-6-18 Authors: Palmisani F, Teko K, Bebington C, Brisighelli G Key Points * Traditional enemas represent a significant and underrecognized mechanism of pediatric perineal trauma in low-resource settings * 75% continence rate achieved through surgical reconstruction, with median

Anesthesiology

A structured protocol for Preoperative Progressive Pneumoperitoneum (PPP) in Complex Abdominal Wall Reconstruction (CAWR): our York protocol

PMCID: PMC12174292 PMID: 40526283 DOI: 10.1007/s10029-025-03401-z Journal: Hernia : the journal of hernias and abdominal wall surgery Publication Date: 2025-6-17 Authors: Abbas AA, Ahmad A, McCleary A, Nicholls M, Chitsabesan P, et al. Key Points * First comprehensive, multidisciplinary protocol specifically designed for complex abdominal wall reconstruction * Systematic seven-week perioperative