Ethan Littlefield - CurrentMed (Page 12)

Pharmacology

Long‐Acting Injectable Antipsychotic Use and Discontinuation Rates in Children and Adolescents With Schizophrenia Using Medicaid Claims Data

PMCID: PMC12172391 PMID: 40525645 DOI: 10.1111/eip.70063 Journal: Early intervention in psychiatry Publication Date: 2025-6-17 Authors: Ward TM, Xu J, Hall DB, Chen X, Benavides S, et al. Key Points * LAI antipsychotics represent an emerging treatment strategy for pediatric psychiatric populations, potentially improving medication adherence * Paliperidone palmitate showed

Pharmacology

An Acrolein-Based Drug Delivery System Enables Tumor-Specific Sphingosine-1-Phosphate Targeting in Breast Cancer without Lymphocytopenia

PMCID: PMC12174973 PMID: 40528704 DOI: 10.1158/2767-9764.CRC-25-0023 Journal: Cancer research communications Publication Date: 2025-6 Authors: Nagahashi M, Komatsu M, Urano S, Kuroiwa M, Takahashi Y, et al. Key Points * Pro-FTY selectively targets and inhibits breast cancer cells, including multidrug-resistant variants, using an acrolein-responsive drug delivery system * Demonstrated 100%

Obstetrics_Gynecology

What matters to you? Improving the adoption of shared decision-making for birth planning in women with chronic hypertension: a multicentre multiple methods study

PMCID: PMC12182189 PMID: 40527566 DOI: 10.1136/bmjopen-2024-094607 Journal: BMJ open Publication Date: 2025 Authors: Whybrow R, Chappell L, Webster L, Girling J, Brown H, et al. Key Points * Women with chronic hypertension experienced limited involvement in birth planning, with only 34.6% of case notes documenting patient participation * Caesarean

Neurology

The Role of Iron Homeostasis Imbalance in T2DM‐Associated Cognitive Dysfunction: A Prospective Cohort Study Utilizing Quantitative Susceptibility Mapping

PMCID: PMC12175199 PMID: 40530831 DOI: 10.1002/hbm.70263 Journal: Human brain mapping Publication Date: 2025-6-18 Authors: Cheng Z, Yang L, Li M, Zhang Q, Li J, et al. Key Points * T2DM patients showed significantly higher iron deposition in caudate and putamen nuclei compared to healthy controls * Higher magnetic susceptibility

Emergency_Medicine

Clinical characteristics and resource utilization of emergency department patients with obstructive sleep apnea

PMCID: PMC12173181 PMID: 40526732 DOI: 10.1371/journal.pone.0326194 Journal: PloS one Publication Date: 2025-6-17 Authors: Sun M, Zhang X, Liu YC, Pei J, Fan H, et al. Key Points * OSA patients represent a distinct, high-acuity subgroup in emergency departments, with unique demographic and clinical characteristics * Adjusted odds ratios

Immunology

Narrowing Down Key Players in Autoimmunity via Single‐Cell Multiomics

PMCID: PMC12177686 PMID: 40534591 DOI: 10.1002/eji.202451233 Journal: European journal of immunology Publication Date: 2025-6-19 Authors: Gjurgjaj A, Conde CD Key Points * Single-cell multiomics provides unprecedented insights into the molecular mechanisms underlying autoimmune diseases * Emerging computational integration and deep-learning tools show promise for disease stratification and drug prioritization

Surgery

Ilizarov-assisted periosteal distraction for refractory arteriovenous malformation ulcers: first clinical report in Asia

PMCID: PMC12175424 PMID: 40533860 DOI: 10.1186/s41065-025-00479-4 Journal: Hereditas Publication Date: 2025-6-18 Authors: Wu X, Cai R, Ye M, Yang X, Sun D, et al. Key Points * Ilizarov periosteal distraction provides a novel mechanotherapeutic approach for AVM-related ischemic ulcers * 75% wound epithelialization achieved within 4 weeks of intervention * Offers

Neurology

Comparing clinical features of behavioral variant frontotemporal dementia and Alzheimer's disease using network analysis

PMCID: PMC12173837 PMID: 40528277 DOI: 10.1002/alz.70361 Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association Publication Date: 2025-6-17 Authors: Goodwin GJ, Mehrzad S, Cummings JL, Renn BN, Kinney JW, et al. Key Points * Bridge symptoms differ markedly between AD and bvFTD, with

Gastroenterology

Clinical outcomes of conventional versus extended mesenteric resection in limited ileo-colonic Crohn’s disease: a systematic review and meta-analysis

PMCID: PMC12174243 PMID: 40528089 DOI: 10.1007/s00384-025-04937-3 Journal: International journal of colorectal disease Publication Date: 2025-6-18 Authors: Mostafa OE, Zaman S, Malik M, Kumar P, Kumar L, et al. Key Points * No significant clinical advantage was observed with extended mesenteric resection compared to conventional resection in Crohn's

Immunology

Clinical factors associated with growth and neoantigen reactivity of tumor infiltrating lymphocytes from metastatic epithelial cancers

PMCID: PMC12179044 PMID: 40536705 DOI: 10.1007/s00262-025-04091-3 Journal: Cancer immunology, immunotherapy : CII Publication Date: 2025-6-19 Authors: Gustafson AM, Dinerman AJ, Hitscherich KJ, Parkhurst MR, Halas H, et al. Key Points * Lung metastases demonstrated superior TIL growth (95%) compared to other resection sites * 51% of TIL harvests showed high neoantigen

Pharmacology

Garsorasib, a KRAS G12C inhibitor, with or without cetuximab, an EGFR antibody, in colorectal cancer cohorts of a phase II trial in advanced solid tumors with KRAS G12C mutation

PMCID: PMC12170901 PMID: 40523897 DOI: 10.1038/s41392-025-02274-z Journal: Signal transduction and targeted therapy Publication Date: 2025-6-17 Authors: Ruan DY, Wu HX, Xu Y, Munster PN, Deng Y, et al. Key Points * First study with the highest proportion of Asian mCRC patients receiving a KRAS G12C inhibitor, demonstrating promising anti-tumor

Pharmacology

Pharmacokinetics and Tissue Distribution of Palmatine after Single Intramuscular Injection in Partridge Shank Chickens

PMCID: PMC12178312 PMID: 40536902 DOI: 10.1002/vms3.70416 Journal: Veterinary medicine and science Publication Date: 2025-6-19 Authors: Chen C, A‐ga YB, Kuang X, Li Y, Xiang R, et al. Key Points * Palmatine demonstrates rapid absorption and distribution in Partridge Shank chickens following intramuscular administration * Peak plasma concentration of