Ethan Littlefield - CurrentMed (Page 11)

Pathology

Inflammatory cells and remodeling in bronchial biopsies from COPD patients and controls

PMCID: PMC12173230 PMID: 40526700 DOI: 10.1371/journal.pone.0326267 Journal: PloS one Publication Date: 2025-6-17 Authors: Eagan TM, Nielsen R, Haaland I, Husebø GR, Lehmann S, et al. Key Points * COPD patients exhibit increased macrophage and eosinophil populations in bronchial submucosa * GOLD stages I/II demonstrated higher eosinophil counts

Surgery

A prospective randomized clinical trial to evaluate wound healing, cosmetic and functional results as well as postoperative adverse events comparing two types of dressing technique after hypospadias repair

PMCID: PMC12177010 PMID: 40533580 DOI: 10.1007/s00383-025-06063-1 Journal: Pediatric surgery international Publication Date: 2025-6-18 Authors: Lawo K, Feller D, Klein BS, Holland-Cunz SG, Frech-Dörfler M Key Points * No significant difference was observed between film and silver pad dressing techniques in wound healing or cosmetic outcomes * Wound dehiscence rate was

Neurology

Brain fluid physiology in ischaemic stroke; more than just oedema

PMCID: PMC12175363 PMID: 40533800 DOI: 10.1186/s12987-025-00671-8 Journal: Fluids and barriers of the CNS Publication Date: 2025-6-18 Authors: Coupland KG, Amell MF, Spratt NJ Key Points * Ischaemic stroke acutely alters CSF and ISF movement, contributing to secondary brain injury * Disrupted fluid dynamics may compromise waste clearance and increase intracranial

Oncology

Oral Soft Tissue and Jawbone Sarcomas: A Retrospective Clinicopathologic Analysis of 128 Cases from Two Institutions and Comprehensive Literature Review

PMCID: PMC12174025 PMID: 40526340 DOI: 10.1007/s12105-025-01811-0 Journal: Head and neck pathology Publication Date: 2025-6-17 Authors: Argyris PP, Dennis GR, Gopalakrishnan R, Koutlas IG, McNamara KK, et al. Key Points * Osteosarcoma and Kaposi sarcoma collectively represent two-thirds of oral soft tissue and jawbone sarcomas * Male-to-female ratio of 1.5:

Neurology

Risk of ischemic stroke associated with anti-rheumatic agents in patients with rheumatoid arthritis: A nationwide population-based case-control study

PMCID: PMC12173416 PMID: 40526615 DOI: 10.1371/journal.pone.0326311 Journal: PloS one Publication Date: 2025-6-17 Authors: Ahn SM, Kim S, Kim YJ, Hong S, Lee CK, et al. Key Points * Sulfasalazine and hydroxychloroquine were associated with reduced stroke risk in RA patients * Glucocorticoids showed a 71% increased stroke risk

Pharmacology

Trends of potentially inappropriate prescribing among older outpatients in China between 2015–21

PMCID: PMC12178595 PMID: 40537054 DOI: 10.7189/jogh.15.04190 Journal: Journal of global health Publication Date: 2025-6-20 Authors: Tian F, Chen Z, Zhang Y, Feng Q Key Points * Overall PIP prevalence remained stable at approximately 29%, but multiple PIM-related prescriptions increased (AAPC = 4.45) * Sedative-hypnotic medications showed significant upward

Pharmacology

Targeting circulating tumor cell‒neutrophil interactions: nanoengineered strategies for inhibiting cancer metastasis

PMCID: PMC12175327 PMID: 40528159 DOI: 10.1186/s12951-025-03522-8 Journal: Journal of nanobiotechnology Publication Date: 2025-6-17 Authors: Su Y, Leng M, Yang Q, Jiang W, Xiang G, et al. Key Points * Neutrophil-CTC interactions are a critical mechanism driving cancer metastasis through multiple biological processes * Nanotechnology-based drug delivery systems show promise in

Surgery

The impact of anemia on early postoperative complications in aseptic revision total shoulder arthroplasty

PMCID: PMC12177007 PMID: 40531329 DOI: 10.1007/s00590-025-04372-8 Journal: European journal of orthopaedic surgery & traumatology : orthopedie traumatologie Publication Date: 2025-6-18 Authors: Liu SH, Leonardo CJ, Loyst RA, Konnayil BJ, Bramian A, et al. Key Points * Preoperative anemia is independently associated with increased 30-day postoperative complications in revision total shoulder

Anesthesiology

Transformative Dental Care in Pediatric Moebius Syndrome: Bridging Oral Health and Systemic Management During Prolonged Hospitalization

PMCID: PMC12172574 PMID: 40525838 DOI: 10.1111/scd.70031 Journal: Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry Publication Date: 2025-6-17 Authors: Delgado RZ, Bueno M, Mugayar L, Franco JB Key

Endocrinology

Density of ectopic fat depots predict distinct biomarkers of glycemic and insulinemic status in persons with HIV

PMCID: PMC12177074 PMID: 40533477 DOI: 10.1038/s41387-025-00381-y Journal: Nutrition & diabetes Publication Date: 2025-6-18 Authors: Park S, Widmer A, Swartz AZ, Koethe JR, Silver HJ Key Points * PWH with diabetes showed significantly altered tissue densities, with 2.5-fold higher hepatic steatosis prevalence compared to those without diabetes * Myosteatosis was

Emergency_Medicine

Serious Illness Conversations in the Emergency Department for Older Adults With Advanced Illnesses: A Randomized Clinical Trial

PMCID: PMC12177648 PMID: 40531532 DOI: 10.1001/jamanetworkopen.2025.16582 Journal: JAMA network open Publication Date: 2025-6-18 Authors: Ouchi K, Block SD, Rentz DM, Berry DL, Oelschlager H, et al. Key Points * Nurse-led ED intervention increased clinician-documented serious illness conversations without significant patient-reported engagement * Clinician documentation of SICs increased from

Immunology

Gut Microbiota Reshapes the Tumor Microenvironment and Affects the Efficacy of Colorectal Cancer Immunotherapy

PMCID: PMC12175482 PMID: 40530896 DOI: 10.1002/cam4.70994 Journal: Cancer medicine Publication Date: 2025-6-18 Authors: Wang F, Chen W, Jia Y, He T, Wu S, et al. Key Points * Intestinal microbiota significantly modulates immunotherapy response in colorectal cancer * Specific bacterial strains can enhance CD8+ T cell infiltration and cytotoxicity