Nephrology

Efficacy of Nrf2 activation in a proteinuric Alport syndrome mouse model

PMCID: PMC12174586 PMID: 40527586 DOI: 10.26508/lsa.202503330 Journal: Life science alliance Publication Date: 2025-6-17 Authors: Kaseda S, Horizono J, Sannomiya Y, Kuwazuru J, Suico MA, et al. Key Points * UD-051, a novel Keap1-Nrf2 protein interaction inhibitor, demonstrated kidney protective effects in Alport syndrome by targeting tubular injury * Combination

Nephrology

A Study on the Neurological Mechanisms of the Impact of Different Dialysis Methods on Brain Structure and Functional Network Dynamic Reorganization in Patients With End‐Stage Renal Disease Undergoing Dialysis

PMCID: PMC12177206 PMID: 40534242 DOI: 10.1002/brb3.70623 Journal: Brain and behavior Publication Date: 2025-6-18 Authors: Han H, Chen H, Zhang Y, Wei J Key Points * Peritoneal dialysis demonstrated superior cognitive preservation compared to hemodialysis * MMSE scores improved from 16.01 to 19.56 in the peritoneal dialysis group

Nephrology

Efficacy of Nrf2 activation in a proteinuric Alport syndrome mouse model

PMCID: PMC12174586 PMID: 40527586 DOI: 10.26508/lsa.202503330 Journal: Life science alliance Publication Date: 2025-6-17 Authors: Kaseda S, Horizono J, Sannomiya Y, Kuwazuru J, Suico MA, et al. Key Points * UD-051, a novel Keap1-Nrf2 protein interaction inhibitor, demonstrated kidney protective effects in Alport syndrome by targeting tubular injury * Combination

Nephrology

A Study on the Neurological Mechanisms of the Impact of Different Dialysis Methods on Brain Structure and Functional Network Dynamic Reorganization in Patients With End‐Stage Renal Disease Undergoing Dialysis

PMCID: PMC12177206 PMID: 40534242 DOI: 10.1002/brb3.70623 Journal: Brain and behavior Publication Date: 2025-6-18 Authors: Han H, Chen H, Zhang Y, Wei J Key Points * Peritoneal dialysis demonstrated superior cognitive preservation compared to hemodialysis * MMSE scores improved from 16.01 to 19.56 in the peritoneal dialysis group