Endocrinology

Rice bran extract attenuates cognitive impairment by enhancing pancreatic β-cell insulin secretion in STZ-induced diabetic rats targeting the PPARγ/PDX1 pathway

Ethan Littlefield

05 Jul 2025 — 1 min read

PMCID: PMC12178994

PMID: 40536613

DOI: 10.1007/s11011-025-01639-1

Journal: Metabolic brain disease

Publication Date: 2025-6-19

Authors: Youssef MM, El-Yamany MF, Abdel-Kader RM, Heikal OA

Key Points

RBE treatment significantly restored pancreatic insulin levels and improved β-cell function in diabetic rats
Pancreatic GLUT2 levels increased by 126.495% in RBE-treated diabetic rats
Rice bran extract offers a potential complementary therapeutic approach for managing type 1 diabetes beyond traditional insulin treatment

Summary

This experimental study investigated the potential therapeutic effects of rice bran ethanol extract (RBE) in type 1 diabetes (T1D) using a streptozotocin-induced diabetic rat model. The research focused on exploring RBE's impact on insulin secretion, pancreatic β-cell function, and cognitive outcomes through molecular and physiological assessments. By examining the PPARγ/PDX1 signaling pathway, the study revealed that RBE treatment significantly improved multiple diabetes-related parameters, including blood glucose levels, insulin secretion, and pancreatic cellular function.

The most notable findings demonstrated that RBE treatment led to substantial improvements in pancreatic insulin levels, increasing them by 149.13% compared to untreated diabetic rats. Remarkably, RBE significantly upregulated key genes involved in insulin secretion, such as PPARγ, SERCA, and PrKC, while also restoring cognitive functions. Unlike standard insulin treatment, RBE showed a more comprehensive approach to addressing the metabolic and neurological complications associated with type 1 diabetes.

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