Radiology

Structured light imaging mesoscopy: detection of embedded morphological changes in superficial tissues

Ethan Littlefield

05 Jul 2025 — 1 min read

PMCID: PMC12175002

PMID: 40534904

DOI: 10.1117/1.JBO.30.6.065001

Journal: Journal of biomedical optics

Publication Date: 2025-6-18

Authors: Parsanasab M, Mehendale AM, Karrobi K, Roblyer D, Venugopalan V

Key Points

SLIM provides a novel, non-invasive method for detecting subsurface tissue microstructural changes
Optimal imaging parameters vary significantly based on skin tone, requiring tailored wavelength-frequency approaches
The technique offers potential clinical applications in tracking tissue changes in conditions like skin cancer, aging, and scleroderma

Summary

This computational study introduces Structured Light Imaging Mesoscopy (SLIM), an innovative optical imaging technique designed to detect subsurface tissue structural changes with enhanced precision. Using Monte Carlo simulations on a four-layer skin model, researchers explored how spatial frequency domain (SFD) reflectance measurements can characterize microstructural alterations in the superficial dermis across different skin tones.

The research revealed critical wavelength-spatial frequency (λ-fx) combinations that optimize detection of embedded tissue scattering changes. Notably, the optimal detection parameters varied significantly with skin pigmentation: light skin tones showed maximal reflectance changes at 621 nm and 0.33/mm spatial frequency, while darker skin tones demonstrated optimal detection at near-infrared wavelengths (≥811 nm) and 0.25/mm spatial frequency. The most consistent results across skin tones were achieved using 851 nm wavelength and 0.22/mm spatial frequency.

Status and associated factors of psychological resilience of Chinese medical aid team members under public health emergencies in a cross-sectional study

PMCID: PMC12173397 PMID: 40526630 DOI: 10.1371/journal.pone.0324952 Journal: PloS one Publication Date: 2025-6-17 Authors: Wei X, Liang Y, Huang J Key Points * Psychological resilience is significantly influenced by professional experience, family support, and cultural adaptation * 53.9% of CMATMs reported experiencing loneliness, which negatively impacted psychological resilience

Experimental evolution of a pathogen confronted with innate immune memory increases variation in virulence

PMCID: PMC12176410 PMID: 40532126 DOI: 10.1371/journal.ppat.1012839 Journal: PLoS pathogens Publication Date: 2025-6-18 Authors: Korša A, Baur M, Schulz NK, Anaya-Rojas JM, Mellmann A, et al. Key Points * Immune priming creates selective pressure that increases pathogen virulence variability without compromising host defense mechanisms * 96.6% probability of

Long‐Term or Recurrent Antibiotic Use in Early Life and the Risk of Type 2 Diabetes: A Population‐Based Prospective Cohort and a Case–Control Study

PMCID: PMC12176498 PMID: 40533417 DOI: 10.1111/1753-0407.70113 Journal: Journal of diabetes Publication Date: 2025-6-18 Authors: Li Z, He Q, He X, Xing X, Fu S, et al. Key Points * Long-term or recurrent antibiotic use during childhood may significantly increase type 2 diabetes risk * 26% higher hazard ratio for

Determining the Effects of Emotional Freedom Techniques on Sexual Dysfunction and Self‐Care Management in Women Diagnosed With Multiple Sclerosis

PMCID: PMC12171629 PMID: 40525294 DOI: 10.1002/brb3.70635 Journal: Brain and behavior Publication Date: 2025-6-17 Authors: Çuvadar A, Güneş A, Baş YÇ, Kehaya S Key Points * EFT intervention demonstrated significant improvements in sexual functioning for MS patients * Mean MSISQ-19 primary subscale scores reduced from 10.56 ± 4.11 at