Oncology

Hypoxia‐induced PGK1 expression promotes esophageal squamous cell carcinoma progression via stimulating MYH9‐mediated GSK3β/β‐catenin signalling

Ethan Littlefield

25 Jun 2025 — 1 min read

PMCID: PMC12177104

PMID: 40534132

DOI: 10.1002/ctm2.70376

Journal: Clinical and translational medicine

Publication Date: 2025-6-18

Authors: Xu J, Wu L, Chen T, Liu Y, Zhang Y, et al.

Key Points

Elevated PGK1 levels correlate with poor survival and advanced tumor stages in ESCC patients
PGK1 promotes tumor progression through MYH9-mediated β-catenin/c-Myc pathway activation
Potential biomarker for predicting postoperative prognosis and recurrence risk in ESCC

Summary

This comprehensive study investigated the role of Phosphoglycerate kinase 1 (PGK1) in esophageal squamous cell carcinoma (ESCC), revealing critical insights into tumor progression and potential therapeutic targeting. Through extensive molecular and clinical analyses, researchers demonstrated that elevated PGK1 levels are strongly associated with poor patient survival, advanced tumor characteristics, and increased metastatic potential.

The research uncovered a complex molecular mechanism where PGK1 interacts with myosin-9 (MYH9) to activate the β-catenin/c-Myc signaling pathway, particularly under hypoxic conditions. By facilitating MYH9-mediated ubiquitination and degradation of GSK-3β, PGK1 promotes tumor stemness, epithelial-mesenchymal transition (EMT), and enhanced migratory capacity of ESCC cells. These findings suggest PGK1 as a potential prognostic biomarker and therapeutic target for improving ESCC patient outcomes.

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