Oncology

ESRP1 exerts anti-tumor role by promoting ferroptosis in diffuse-type gastric cancer

Ethan Littlefield

05 Jul 2025 — 1 min read

PMCID: PMC12175430

PMID: 40528239

DOI: 10.1186/s13046-025-03435-2

Journal: Journal of experimental & clinical cancer research : CR

Publication Date: 2025-6-18

Authors: Xu K, Chen H, Zhu X, Li H, Liu X, et al.

Key Points

High ESRP1 expression is an independent prognostic factor for improved survival in diffuse-type gastric cancer
Multivariate analysis showed ESRP1 high expression associated with favorable overall survival (HR: 0.23, 95% CI: 0.08–0.62, p = 0.004)
ESRP1 may serve as a potential therapeutic target for personalized DGC intervention through ferroptosis modulation

Summary

This comprehensive study investigated the role of ESRP1 in diffuse-type gastric cancer (DGC), revealing its potential as a critical prognostic biomarker and therapeutic target. Through extensive bioinformatics analysis and experimental models, researchers demonstrated that high ESRP1 expression correlates with improved survival outcomes specifically in DGC patients, distinguishing it from other gastric cancer subtypes.

The research uncovered a novel mechanistic pathway where ESRP1 inhibits DGC progression by interacting with DHCR7 and enhancing ferroptosis susceptibility. In vitro and in vivo experiments consistently showed that ESRP1 overexpression suppresses tumor cell proliferation, migration, and metastasis, while promoting cancer cell death through ferroptosis-related mechanisms. These findings suggest potential personalized treatment strategies, with ferroptosis-inducing therapies recommended for ESRP1-high patients and alternative small-molecule drugs identified for ESRP1-low cases.

Status and associated factors of psychological resilience of Chinese medical aid team members under public health emergencies in a cross-sectional study

PMCID: PMC12173397 PMID: 40526630 DOI: 10.1371/journal.pone.0324952 Journal: PloS one Publication Date: 2025-6-17 Authors: Wei X, Liang Y, Huang J Key Points * Psychological resilience is significantly influenced by professional experience, family support, and cultural adaptation * 53.9% of CMATMs reported experiencing loneliness, which negatively impacted psychological resilience

Structured light imaging mesoscopy: detection of embedded morphological changes in superficial tissues

PMCID: PMC12175002 PMID: 40534904 DOI: 10.1117/1.JBO.30.6.065001 Journal: Journal of biomedical optics Publication Date: 2025-6-18 Authors: Parsanasab M, Mehendale AM, Karrobi K, Roblyer D, Venugopalan V Key Points * SLIM provides a novel, non-invasive method for detecting subsurface tissue microstructural changes * Optimal imaging parameters vary significantly

Experimental evolution of a pathogen confronted with innate immune memory increases variation in virulence

PMCID: PMC12176410 PMID: 40532126 DOI: 10.1371/journal.ppat.1012839 Journal: PLoS pathogens Publication Date: 2025-6-18 Authors: Korša A, Baur M, Schulz NK, Anaya-Rojas JM, Mellmann A, et al. Key Points * Immune priming creates selective pressure that increases pathogen virulence variability without compromising host defense mechanisms * 96.6% probability of

Long‐Term or Recurrent Antibiotic Use in Early Life and the Risk of Type 2 Diabetes: A Population‐Based Prospective Cohort and a Case–Control Study

PMCID: PMC12176498 PMID: 40533417 DOI: 10.1111/1753-0407.70113 Journal: Journal of diabetes Publication Date: 2025-6-18 Authors: Li Z, He Q, He X, Xing X, Fu S, et al. Key Points * Long-term or recurrent antibiotic use during childhood may significantly increase type 2 diabetes risk * 26% higher hazard ratio for