Oncology

Targeting Drp1 inhibits ESCC progression via the ROS-PGC1-α-Nrf1/2 pathway

Ethan Littlefield

05 Jul 2025 — 1 min read

PMCID: PMC12175380

PMID: 40528181

DOI: 10.1186/s12967-025-06697-8

Journal: Journal of translational medicine

Publication Date: 2025-6-17

Authors: Jiang Z, Yang Y, Zhou J, Li X, Meng Q, et al.

Key Points

Drp1 overexpression is a significant driver of ESCC growth and metastasis
High Drp1 expression correlates with poor patient prognosis
miR-203a-3p represents a potential novel therapeutic intervention for ESCC progression

Summary

This study investigated the role of Dynamin-related protein 1 (Drp1) in esophageal squamous cell carcinoma (ESCC) progression, addressing a critical gap in understanding early-stage cancer metastasis mechanisms. By employing comprehensive research methods including database analysis, immunohistochemistry, functional cell experiments, and mouse models, researchers discovered that high Drp1 expression correlates with poor patient prognosis and significantly enhances ESCC cell growth and metastatic potential.

The research revealed a complex molecular mechanism wherein Drp1 overexpression activates the PGC1-α-Nrf1/2 signaling pathway and promotes epithelial-mesenchymal transition (EMT), facilitating tumor cell metastasis. Notably, miR-203a-3p was identified as a potential therapeutic target, demonstrating the ability to down-regulate Drp1 expression and inhibit ESCC cell malignant progression through the ROS-PGC1-α-Nrf1/2 pathway.

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