Neurology

Longitudinal assessment of cognitive function in testicular cancer patients prior to orchiectomy and 9 months later and associations with tumor markers

Ethan Littlefield

25 Jun 2025 — 1 min read

PMCID: PMC12174274

PMID: 40526183

DOI: 10.1007/s00520-025-09637-w

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Publication Date: 2025-6-17

Authors: Højris NF, Frederiksen Y, Agerbæk M, Nielsen SH, Holt M, et al.

Key Points

Low prevalence of cognitive impairment (10.3% pre-surgery, 0% post-surgery)
Statistically significant global cognitive score decrease (p=.03)
Tumor markers (LDH, AFP) may have subtle associations with cognitive performance

Summary

This longitudinal study investigated cognitive function in testicular cancer patients (TCPs) before and after orchiectomy, utilizing the Cambridge Neuropsychological Test Automated Battery to assess potential cognitive impairment (CI). Of 48 eligible patients, 29 participated, with 20 completing follow-up assessments at 9 months post-surgery. The research revealed a statistically significant, though subtle, decrease in global cognitive score (GCS) from pre- to post-orchiectomy (p=.03), with only a low prevalence of clinically significant cognitive impairment.

Notably, the study uncovered potential associations between tumor markers and cognitive performance. Lactate dehydrogenase (LDH) showed statistically significant correlations with several cognitive domains (r's = −.48 to −.52), while alpha-fetoprotein (AFP) demonstrated a significant relationship with executive function (r = −.44). Despite these findings, overall cognitive performance remained within the normative range, suggesting that orchiectomy may have minimal immediate neuropsychological impact.

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