Obstetrics_Gynecology

Association of Sleep, Inflammation and Female Infertility: A Cross‐Sectional Survey and Genetic Approach

Ethan Littlefield

05 Jul 2025 — 1 min read

PMCID: PMC12171637

PMID: 40525280

DOI: 10.1002/brb3.70627

Journal: Brain and behavior

Publication Date: 2025-6-17

Authors: Xin X, Li J, Zhang J, Wu H

Key Points

Sleep disorders significantly alter inflammatory markers in women of reproductive age
Specific sleep traits (insomnia, sleep efficiency) correlate with inflammatory proteins linked to fertility
Screening and managing inflammatory markers in patients with sleep disorders may improve reproductive outcomes

Summary

This Mendelian randomization (MR) study investigated the complex relationships between sleep disorders, inflammation, and female infertility using the 2013-2020 National Health and Nutrition Examination Survey (NHANES) data. The research focused on 370 infertile women aged 20-44 years, examining how sleep patterns interact with inflammatory markers and potentially impact reproductive health.

The study revealed significant associations between sleep disorders and inflammatory markers, particularly the platelet-lymphocyte ratio (PLR). After adjusting for confounders, sleep disorders were linked to a reduction in PLR (β = −0.145, 95% CI: −0.267 to −0.023, p < 0.05). Genetic analysis suggested that specific sleep traits, including insomnia and sleep efficiency, were associated with inflammatory proteins like oncostatin-M and adenosine deaminase, which may influence fertility. Notably, morning chronotype was associated with reduced infertility risk through inflammatory pathways.

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